ジユウジヨウ　ケンタロウ   Jiyuujiyou Kentarou   重城　健太郎    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of the association between sleep apnea and polyunsaturated fatty acids profiles in patients after percutaneous coronary intervention.
掲載誌名	正式名：Heart and vessels 略　 称：Heart Vessels ISSNコード：09108327/16152573
掲載区分	国外
出版社	Springer Japan
巻・号・頁	32(11),pp.1296-1303
著者・共著者	NAKABAYASHI Keisuke†, JUJO Kentaro*, SAITO Katsumi, OKA Toshiaki, HAGIWARA Nobuhisa
担当区分	責任著者
発行年月	2017/06
概要	The long-term outcome is poor in patients with sleep apnea and cardiovascular disease. Polyunsaturated fatty acid (PUFA) is also known as an independent predictor for adverse clinical events. However, the profle of PUFA in sleep apnea patients with coronary artery disease (CAD) is still unclear. This study aimed to clarify the association between sleep apnea and PUFA profles in patients with CAD. Two hundred seventy-four consecutive patients undergoing percutaneous coronary intervention (PCI) were screened for sleep apnea using nocturnal oximetry. Oxygen desaturation index down to 4% (4%ODI) ≥5 was used as an indicator of sleep apnea. Baseline characteristics, including PUFA profles, were compared between patients with and without sleep apnea. Among 243 enrolled patients, 134 (55%) had sleep apnea. The sleep apnea group included a signifcantly higher rate of patients with obesity, insulinrequiring diabetes, peripheral artery disease (PAD), and a higher C-reactive protein level than the non-sleep apnea group. The sleep apnea group had a signifcantly lower eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio than the non-sleep apnea group (0.33 vs. 0.44, respectively, p = 0.024). Additionally, EPA value and EPA/AA ratio were signifcantly correlated with 4%ODI (r = −0.15, p = 0.028; r = −0.16, p = 0.019, respectively). Results of logistic regression analysis indicated that the comorbidities of obesity, PAD, heart failure and EPA/AA ratio had a signifcant association with sleep apnea. Our results suggested that patients with sleep apnea who underwent PCI had a lower EPA/AA ratio than those without sleep apnea, and EPA value and EPA/AA ratio were signifcantly correlated with 4%ODI.
DOI	10.1007/s00380-017-1010-7
PMID	28631078