イシヅカ　ツトム   Ishizuka Tsutomu   石塚　敏    所属   その他 その他    職種   臨床検査副技師長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The mechanism responsible for accommodation after living-related kidney transplantations across the blood barrier.
掲載誌名	正式名：Transplant international : official journal of the European Society for Organ Transplantation 略　 称：Transpl Int ISSNコード：0934-0874(Print)34-0874(Linking)
掲載区分	国外
巻・号・頁	18(6),pp.716-20
著者・共著者	Ishida Hideki, Tanabe Kazunari, Ishizuka Tsutomu, Furusawa Miyuki, Miyamoto Naoshi, Ishikawa Nobuo, Shirakawa Hiroki, Shimmura Hiroaki, Ishii Daisuke, Nozaki Taishi, Setoguchi Kiyoshi, Toma Hiroshi
発行年月	2005/06
概要	The mechanism responsible for accommodation in renal transplantations across the blood barrier remains unclear. We recently encountered two patients with accommodated status after living-related kidney transplantations across the blood barrier. Both developed elevations of anti-blood-group antibodies to titers over 128x after transplantation, despite excellent renal function. We investigated the serum samples after the establishment of accommodation bound to the erythrocyte membrane of the donors or the third party with the same blood group. After the establishment of accommodation, the serum samples from both accommodated patients demonstrated a significant decrease in binding to the donors' erythrocyte membrane, but did not show any decrease in binding to the erythrocyte membrane of the third party. By contrast, serum samples from patients with graft loss after unsuccessful accommodation showed high anti-blood-type antibody activity directed towards both the donor's and the third party's erythrocytes. The result of this study suggests the difference of quality in antibodies produced by accommodated and nonaccommodated recipients.
DOI	10.1111/j.1432-2277.2005.00131.x
文献番号	15910299