イシイ　ヤスオ   Ishii Yasuo   石井　泰雄    所属   医学部 医学科    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote.
掲載誌名	正式名：Developmental dynamics : an official publication of the American Association of Anatomists 略　 称：Dev Dyn ISSNコード：(1058-8388)1058-8388(Linking)
掲載区分	国外
巻・号・頁	229(3),pp.422-32
著者・共著者	Mikawa Takashi, Poh Alisa M, Kelly Kristine A, Ishii Yasuo, Reese David E
発行年月	2004/03
概要	The primitive streak is the organizing center for amniote gastrulation. It defines the future embryonic midline and serves as a conduit of cell migration for germ layer formation. The migration patterns of endodermal and mesodermal precursors through the streak have been studied in great detail. Additional new breakthroughs recently have revealed the cell biological and molecular mechanisms that govern streak induction and patterning. These findings include (1) identification of the ontogeny and inductive signals of streak precursors, (2) the potential cellular mechanism of streak extension, and (3) the molecular and functional diversification along the anterior-posterior and mediolateral axes within the primitive streak. These findings indicate that amniote embryos initiate gastrulation by using both evolutionarily conserved and divergent mechanisms. The data also provide a foundation for understanding how the midline axis is defined and maintained during gastrulation of the amniotes.
DOI	10.1002/dvdy.10458
PMID	14991697