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オシブチ ヒデヒロ
OSHIBUCHI Hidehiro
押淵 英弘 所属 医学部 医学科（東京女子医科大学病院） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. |
| 掲載誌名 | 正式名：Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 略 称：Neuropsychopharmacology ISSNコード：(1740-634X)0893-133X(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 41(5),pp.1404-15 |
| 著者・共著者 | Urban Daniel J, Zhu Hu, Marcinkiewcz Catherine A, Michaelides Michael, Oshibuchi Hidehiro, Rhea Darren, Aryal Dipendra K, Farrell Martilias S, Lowery-Gionta Emily, Olsen Reid H J, Wetsel William C, Kash Thomas L, Hurd Yasmin L, Tecott Laurence H, Roth Bryan L |
| 発行年月 | 2016/04 |
| 概要 | Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes-hours) and long period of time (days-weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness, reversibility, and spatio-temporal control. Recently, we have demonstrated that our chemogenetic approach (eg, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)) provides a reliable and robust tool for controlling genetically defined neural populations. Here we show how short- and long-term activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses. We found that both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavioral responses. However, only short-term activation induces anxiogenic-like behaviors. In parallel, these behavioral phenotypes were associated with a metabolic map of whole brain network activity via a recently developed non-invasive imaging technology DREAMM (DREADD Associated Metabolic Mapping). Our findings reveal a previously unappreciated brain network elicited by selective activation of DRN serotonin neurons and illuminate potential therapeutic and adverse effects of drugs targeting DRN neurons. |
| DOI | 10.1038/npp.2015.293 |
| PMID | 26383016 |