オオツキ　ヒサオ   Ootsuki Hisao   大槻　尚男    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lesion characteristics of coronary arteries associated with a mismatch between angiographic severity of stenosis and fractional flow reserve.
掲載誌名	正式名：Cardiovascular intervention and therapeutics 略　 称：Cardiovasc Interv Ther ISSNコード：18684300/18684297
掲載区分	国内
出版社	Springer Japan
巻・号・頁	32(2),pp.120-126
著者・共著者	ARASHI Hiroyuki†, YAMAGUCHI Junichi*, NAKAZAWA Mayui, OOTSUKI Hisao, HARUKI Shintaro, NAKAO Masashi, KAMISHIMA Kazuho, JUJO Kentaro, MINAMI Yuichiro, TAKAGI Atsushi, OGAWA Hiroshi, HAGIWARA Nobuhisa
発行年月	2017/04
概要	We aimed to clarify the relationships between angiographic lesion characteristics and values of fractional flow reserve (FFR) on intermediate coronary artery stenosis. The clinical meaning and assessment for "visual-functional mismatches," including regular-mismatches [defined as angiographic percent diameter stenosis (%DS) ≥50 % and FFR >0.80] and reverse-mismatches (defined as angiographic %DS <50 %, FFR ≤0.80) remains unresolved in contemporary practice. We retrospectively enrolled 140 consecutive patients who underwent coronary angiography and FFR measurement. One hundred fifty-seven cases of intermediate coronary artery stenosis were evaluated. The relationship between clinical/lesion characteristics and regular- or reverse-mismatches were examined. Lesions in the left anterior descending artery (LAD) showed significantly lower frequency of regular-mismatch than did non-LAD lesions (26.7 vs. 73.3 %, respectively; p < 0.001). Conversely, almost all reverse-mismatches were observed in LAD lesions (93.8 %). The best cut-off value of %DS, derived from receiver operating characteristic (ROC) curve analysis, to predict FFR ≤0.8 was 45.0 % in LAD lesions and 67.5 % in non-LAD lesions. FFR measurement should be considered in LAD intermediate lesions to avoid residual functional ischemia and in non-LAD lesions to avoid unnecessary coronary intervention.
DOI	10.1007/s12928-016-0399-8
PMID	27236812