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サイトウ タイイチ
SAITO Taiichi
齋藤 太一 所属 医学研究科 医学研究科 (医学部医学科をご参照ください) 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. |
| 掲載誌名 | 正式名：Journal of neuro-oncology 略 称：J Neurooncol ISSNコード：0167-594X(Print)594X(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 77(3),pp.273-7 |
| 著者・共著者 | Arifin Muhamad Thohar, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Saito Taiichi, Matsuura Shinya, Yamasaki Fumiyuki, Arita Kazunori, Kurisu Kaoru |
| 発行年月 | 2006/05 |
| 概要 | BACKGROUND:The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated.METHODS:p16 Expression was examined in 20 anaplastic astrocytoma and 42 glioblastoma patients by immunohistochemical analysis, and the relationship between both cytoplasmic and nuclear p16 expression and prognosis analyzed.RESULTS:The cytoplasmic expression of p16 statistically correlated with poor prognosis. On the other hand, no correlation was observed between p16 nuclear expression and patient survival.CONCLUSION:The cytoplasmic immunoreactivity of p16 appears to be an unfavorable prognostic indicator in high-grade astrocytoma patients. The localization of p16 expression should be determined when evaluating the prognosis of these patients. |
| DOI | 10.1007/s11060-005-9037-5 |
| 文献番号 | 16614947 |