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サイトウ タイイチ
Saitou Taiichi
齋藤 太一 所属 医学研究科 医学研究科 (医学部医学科をご参照ください) 職種 非常勤講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Role of perfusion-weighted imaging at 3T in the histopathological differentiation between astrocytic and oligodendroglial tumors. |
| 掲載誌名 | 正式名：European journal of radiology 略 称：Eur J Radiol ISSNコード：1872-7727(Electronic)0720-048X(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 81(8),pp.1863-9 |
| 著者・共著者 | Saito Taiichi, Yamasaki Fumiyuki, Kajiwara Yoshinori, Abe Nobukazu, Akiyama Yuji, Kakuda Takako, Takeshima Yukio, Sugiyama Kazuhiko, Okada Yoshikazu, Kurisu Kaoru |
| 発行年月 | 2012/08 |
| 概要 | OBJECTIVE:The differentiation of oligodendroglial tumors from astrocytic tumors is important clinically, because oligodendroglial tumors are more chemosensitive than astrocytic tumors. This study was designed to clarify the usefulness of 3T MR perfusion imaging (PWI) in the histopathological differentiation between astrocytic and oligodendroglial tumors. This is because there is a growing interest in the diagnostic performance of 3T MR imaging, which has the advantages of a higher signal-to-noise ratio (SNR) and greater spatial and temporal resolution.MATERIALS AND METHODS:This study retrospectively included 24 consecutive patients with supratentorial, WHO grade II and III astrocytic and oligodendroglial tumors (7 astrocytic, 10 oligoastrocytic, and 7 oligodendroglial tumors) that were newly diagnosed and resected between November 2006 and December 2009 at Hiroshima University Hospital. These patients underwent dynamic susceptibility contrast-enhanced (DSC) PWI relative cerebral blood volume (rCBV) measurements before treatment. Astrocytic tumors were designated as the astrocytic group, and oligoastrocytic and oligodendroglial tumors as the oligodendroglial group. The regions of interest with the maximum rCBV values within the tumors were normalized relative to the contra-lateral white matter (rCBVmax).RESULTS:The average rCBVmax of astrocytic tumors (2.01±0.68) was significantly lower than that of the oligoastrocytic (4.60±1.05) and oligodendroglial tumors (6.17±0.867) (PRESULTS:<RESULTS:0.0001). A cut-off value of 3.0 allowed to differentiate the oligodendroglial group from the astrocytic group at 100% sensitivity and 87.5% specificity.CONCLUSION:The rCBVmax values obtained from 3T MR PWI may be useful as an adjunct to the postoperative histopathological diagnosis of glioma patients. |
| DOI | 10.1016/j.ejrad.2011.04.009 |
| 文献番号 | 21543173 |