サイトウ　タイイチ   Saitou Taiichi   齋藤　太一    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   非常勤講師
論文種別	原著
言語種別	日本語
査読の有無	査読あり
表題	[Anti-emetic effect of granisetron in patients undergoing cranial and craniospinal radiotherapy].
掲載誌名	正式名：No shinkei geka. Neurological surgery 略　 称：No Shinkei Geka ISSNコード：0301-2603(Print)0301-2603(Linking)
掲載区分	国内
巻・号・頁	42(1),27-34頁
著者・共著者	Yamasaki Fumiyuki, Watanabe Yosuke, Nosaka Ryo, Kenjo Masahiro, Nakamura Kazuhiro, Takayasu Takeshi, Saito Taiichi, Tominaga Atsushi, Sugiyama Kazuhiko, Kurisu Kaoru
発行年月	2014/01
概要	PURPOSE:Approximately 30-59% of patients undergoing cranial or craniospinal radiotherapy experience nausea and/or vomiting. Here, we evaluated the effectiveness of granisetron for controlling emesis in patients treated with cranial or craniospinal radiotherapy.PATIENTS AND METHODS:Between December 2011 and January 2013, 34 patients(19 males, 15 females;age range, 3-80 years)received cranial or craniospinal radiotherapy at our department. All but one male patient, who developed meningitis during the irradiation period were enrolled in this retrospective study. Patients who experienced irradiation-induced vomiting(grade 1)or nausea(grade 2)were treated with granisetron as a rescue anti-emetic. Episodes were graded as(1)no vomiting, no nausea, no anti-emetic;(2)no vomiting, nausea, no anti-emetic;(3)no vomiting, nausea with anti-emetic;and(4)vomiting.RESULTS:Of the 9 patients who underwent whole-brain or whole neural-axis irradiation, 5(55.6%)experienced grade 2 nausea or vomiting. Two of 6 patients(33.3%)treated with whole ventricle irradiation experienced grade 2 nausea or vomiting. Three of 18 patients(16.7%)who underwent local-field irradiation experienced grade 2 nausea or vomiting. Patients who underwent wide-field irradiation experienced nausea, vomiting, and anorexia(pRESULTS:<RESULTS:0.05). Complete response(no vomiting, no additional rescue anti-emetic, and no nausea)was observed in 5 of 9 patients treated with granisetron. Four of 9 patients(44.4%)treated with granisetron experienced constipatRESULTS:ion(grade 1 or 2);its administration had no major adverse effects in our study population.CONCLUSION:Rescue therapy with granisetron is safe and effective to treat nausea and vomiting in patients subjected to cranial or craniospinal irradiation.
文献番号	24388937