イシイ　ヤスオ   Ishii Yasuo   石井　泰雄    所属   医学部 医学科    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Endothelial cell lineages of the heart.
掲載誌名	正式名：Cell and tissue research 略　 称：Cell Tissue Res ISSNコード：(1432-0878)0302-766X(Linking)
掲載区分	国外
巻・号・頁	335(1),pp.67-73
著者・共著者	Ishii Yasuo, Langberg Jonathan, Rosborough Kelley, Mikawa Takashi
発行年月	2009/01
概要	During early gastrulation, vertebrate embryos begin to produce endothelial cells (ECs) from the mesoderm. ECs first form primitive vascular plexus de novo and later differentiate into arterial, venous, capillary, and lymphatic ECs. In the heart, the five distinct EC types (endocardial, coronary arterial, venous, capillary, and lymphatic) have distinct phenotypes. For example, coronary ECs establish a typical vessel network throughout the myocardium, whereas endocardial ECs form a large epithelial sheet with no angiogenic sprouting into the myocardium. Neither coronary arteries, veins, and capillaries, nor lymphatic vessels fuse with the endocardium or open to the heart chamber. The developmental stage during which the specific phenotype of each cardiac EC type is determined remains unclear. The mechanisms involved in EC commitment and diversity can however be more precisely defined by tracking the migratory patterns and lineage decisions of the precursors of cardiac ECs.
DOI	10.1007/s00441-008-0663-z
PMID	18682987