イシイ　ヤスオ   Ishii Yasuo   石井　泰雄    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina.
掲載誌名	正式名：Developmental biology 略　 称：Dev Biol ISSNコード：(1095-564X)0012-1606(Linking)
掲載区分	国外
巻・号・頁	413(1),pp.104-11
著者・共著者	Wang Zi, Yasugi Sadao, Ishii Yasuo
担当区分	最終著者,責任著者
発行年月	2016/05
概要	The light-sensitive neural retina (NR) and the retinal pigmented epithelium (RPE) develop from a common primordium, the optic vesicle, raising the question of how they acquire and maintain distinct identities. Here, we demonstrate that sustained misexpression of the Chx10 homeobox gene in the presumptive RPE in chick suppresses accumulation of melanin pigments and promotes ectopic NR-like neural differentiation. This phenotypic change involved ectopic expression of NR transcription factor genes, Sox2, Six3, Rx1 and Optx2, which, when misexpressed, counteracted RPE development without upregulating Chx10. These results suggest that Chx10 can function as a cell autonomous regulator of the regional identity in the primordial retina, presumably through a downstream transcriptional cascade.
DOI	10.1016/j.ydbio.2016.03.023
PMID	27001188