トチモト　アキコ   TOCHIMOTO Akiko   栃本　明子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Genetic Susceptibility to Interstitial Lung Disease Associated with Systemic Sclerosis.
掲載誌名	正式名：Clinical medicine insights. Circulatory, respiratory and pulmonary medicine 略　 称：Clin Med Insights Circ Respir Pulm Med ISSNコード：(1179-5484)1179-5484(Linking)
掲載区分	国外
巻・号・頁	9(Suppl 1),pp.135-40
著者・共著者	Tochimoto Akiko†, Kawaguchi Yasushi*, Yamanaka Hisashi
担当区分	筆頭著者
発行年月	2015
概要	Systemic sclerosis (SSc) is a connective tissue disease that is characterized by tissue fibrosis, microvasculopathy, and autoimmunity. Interstitial lung disease (ILD) is a common complication of SSc and is one of the frequent causes of mortality in SSc. Although the exact etiology of SSc remains unknown, clinical and experimental investigations have suggested that genetic and environmental factors are relevant to the pathogenesis of SSc and SSc-ILD. More than 30 genes have been identified as susceptibility loci for SSc, most of which are involved in immune regulation and inflammation. It is thought that the key pathogenesis of SSc-ILD is caused by the release of profibrotic mediators such as transforming growth factor β1 and connective tissue growth factor from lung cells induced by a persistent damage. This review presents the genetic susceptibility to SSc-ILD, including human leukocyte antigen and non-human leukocyte antigen genes, especially focusing on connective tissue growth factor.
DOI	10.4137/CCRPM.S23312
PMID	26997879