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ナガオ ミチノブ
Nagao Michinobu
長尾 充展 所属 医学部 医学科（東京女子医科大学病院） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac T2* magnetic resonance imaging. |
| 掲載誌名 | 正式名：The American journal of cardiology 略 称：Am J Cardiol ISSNコード：(1879-1913)0002-9149(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 113(6),pp.1024-30 |
| 著者・共著者 | Nagao Michinobu, Matsuo Yoshio, Kamitani Takeshi, Yonezawa Masato, Yamasaki Yuzo, Kawanami Satoshi, Abe Kohtaro, Mukai Yasushi, Higo Taiki, Yabuuchi Hidetake, Takemura Atsushi, Yoshiura Takashi, Sunagawa Kenji, Honda Hiroshi |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2014/03 |
| 概要 | The aim of this study was to use T2* cardiac magnetic resonance (CMR) imaging to quantify myocardial iron content in patients with heart failure (HF) and to investigate the relation between iron content, cardiac function, and the cause of HF. CMR data were analyzed from 167 patients with nonischemic and 31 with ischemic HF and 50 patients with normal ventricular function. Short-axis T2* imaging was accomplished using 3-T scanner and multiecho gradient-echo sequence. Myocardial T2* value (M-T2*) was calculated by fitting the signal intensity data for the mid-left ventricular (LV) septum to a decay curve. Patients with nonischemic HF were categorized into patients with LV ejection fraction (LVEF) <35% or ≥35%. The relation between nonischemic HF with LVEF <35% and the risk for major adverse cardiac events was analyzed by multivariate logistic regression analysis using M-T2* and HF biomarkers. M-T2* was significantly greater for patients with nonischemic HF (LVEF <35%: 29 ± 7 ms, LVEF ≥35%: 26 ± 5 ms) than for patients with normal LV function (22 ± 3 ms, p <0.0001) or ischemic HF (22 ± 4 ms, p <0.001). The odds ratio was 1.21 for M-T2* (p <0.0001) and 1.0015 for brain natriuretic peptide (p <0.0001) in relation to nonischemic HF with LVEF <35%. Furthermore, this value was 0.96 for systolic blood pressure (p = 0.012) and 1.02 for M-T2* (p = 0.03) in relation to the risk for major adverse cardiac events in patients with nonischemic HF. In conclusion, T2* CMR demonstrated the robust relation between myocardial iron deficiency and nonischemic HF. M-T2* is a biomarker that can predict adverse cardiac function in patients with nonischemic HF. |
| DOI | 10.1016/j.amjcard.2013.11.061 |
| PMID | 24461766 |