サトウ　キヨウコ   Satou Kiyouko   佐藤　恭子    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The effect of donepezil treatment on cardiovascular mortality.
掲載誌名	正式名：Clinical pharmacology and therapeutics 略　 称：Clin Pharmacol Ther ISSNコード：(1532-6535)0009-9236(Linking)
掲載区分	国外
巻・号・頁	88(3),pp.335-8
著者・共著者	Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A
担当区分	筆頭著者
発行年月	2010/09
概要	The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer's disease and vascular dementia. Given acetylcholine's important actions on the heart, we undertook a retrospective cohort investigation to assess whether donepezil usage affects cardiovascular mortality. In patients treated with donepezil, hazard ratios for total and cardiovascular mortality were 0.68 (P = 0.045, 95% confidence interval 0.46-0.99) and 0.54 (P = 0.042, 95% confidence interval 0.30-0.98), respectively. The apparent survival benefit in donepezil-treated patients should not be overinterpreted. Prospective clinical trials are warranted.
DOI	10.1038/clpt.2010.98
PMID	20664535