イチハラ　アツヒロ   ICHIHARA Atsuhiro   市原　淳弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322
巻・号・頁	5,pp.8854
著者・共著者	SHIBAYAMA Yuki†, FUJIMORI Takayuki, Genevieve Nguyen, HIROSE Takuo, TOTSUNE Kazuhito, ICHIHARA Atsuhiro, KITADA Kento, NAKANO Daisuke, KOBORI Hiroyuki, KOHNO Masakazu, MASAKI Tsutomu, SUZUKI Yasuyuki, YACHIDA Shinichi, NISHIYAMA Akira
発行年月	2015/03
概要	Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin activation. Recent studies have implicated the (pro)renin receptor ((P)RR) is related to the Wnt/β-catenin signaling pathway. We therefore investigated the possible role of (P)RR in pancreatic carcinogenesis. Plasma s(P)RR levels were significantly (P<0.0001) higher in patients with PDAC than in healthy matched controls. We also identified aberrant expression of (P)RR in premalignant PanIN and PDAC lesions and all the PDAC cell lines examined. Inhibiting (P)RR with an siRNA attenuated activation of Wnt/β-catenin signaling pathway and reduced the proliferative ability of PDAC cells in vitro and the growth of engrafted tumors in vivo. Loss of (P)RR induced apoptosis of human PDAC cells. This is the first demonstration that (P)RR may be profoundly involved in ductal tumorigenesis in the pancreas.
DOI	10.1038/srep08854
PMID	25747895