オカノ　テルオ   Okano Teruo   岡野　光夫    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   評議員
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Nectin-3 expression is elevated in limbal epithelial side population cells with strongly expressed stem cell markers.
掲載誌名	正式名：Biochemical and biophysical research communications 略　 称：Biochem Biophys Res Commun ISSNコード：(1090-2104)0006-291X(Linking)
掲載区分	国外
巻・号・頁	389(2),pp.274-8
著者・共著者	KUSANAGI Risa†, UMEMOTO Terumasa, YAMATO Masayuki, MATSUZAKI Yu, NISHIDA Kohji, KOBAYASHI Yoshiro, FUKAI Fumio, OKANO Teruo*
担当区分	責任著者
発行年月	2009/11
概要	Corneal epithelial stem cells (CESCs) are essential for maintaining the ocular surface. However, the lack of surface markers for CESCs remains a serious obstacle in the identification of CESCs. Previously, we showed that rabbit limbal epithelial side population (rLE-SP) cells exhibited stem cell phenotypes including increased expression of CD61, a marker for mouse hematopoietic stem cells. Here, we demonstrate that nectin-3, an immunoglobulin-like cell-cell adhesion molecule, is highly expressed in rLE-SP cells. Additionally, nectin-3(+) cells were significantly enriched among CD61(+)rLE-SP cells as compared to CD61(-)rLE-SP cells. In mouse bone marrow side population cells, a correlation between expression of nectin-3 and CD61 was also observed. These data strongly suggest that nectin-3 may contribute to the identification of CESCs.
DOI	10.1016/j.bbrc.2009.08.130
PMID	19716807