ツカハラ　フジコ   TSUKAHARA Fujiko   塚原　富士子    所属   医学部 医学科（東京女子医科大学病院）    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example.
掲載誌名	正式名：Endocrine, metabolic & immune disorders drug targets 略　 称：Endocr Metab Immune Disord Drug Targets ISSNコード：18715303/22123873
巻・号・頁	15(2),pp.83-87
著者・共著者	Maru Yoshiro, Tomita Takeshi*, Deguchi Atsuko, Ieguchi Katsuaki, Takita Morichika, Tsukahara Fujiko, Takemura Kazuhiro, Kitao Akio, Gusovsky Fabian
発行年月	2015
概要	TLRs are very important players to regulate innate immune responses. TLR4 controls the host defense by sensing an exotic pathogen, such as lipopolysaccharides. At the same time, some endogenous proteins, including HMGB1 and S100A8, could also function to be a ligand to elicit inflammatory reactions. These facts make TLR4 signaling system very complicated. For instance, the application of TLR4 ligands in cancer therapies is desirable for enhancement of anti-tumor immunity in terms of its reparative nature, but undesirable for enhancement of metastatic growth of cancer cells. In this manuscript, in order to make a novel molecular design to disrupt an interaction between TLR4/MD-2 and endogenous ligands, we provide a potential binding style of the TLR4/MD-2 complex with HMGB1 by using their 3D structural data and docking simulations, and also discuss S100A8 binding to TLR4/MD-2.
DOI	10.2174/187153031502150522123746
PMID	26004773