ウエタ　ヨシフミ   UETA Yoshifumi   植田　禎史    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Dopamine induces a slow afterdepolarization in lateral amygdala neurons.
掲載誌名	正式名：Journal of Neurophysiology 略　 称：J Neurophysiol ISSNコード：0022-3077(Print)0022-3077(Linking)
巻・号・頁	98(2),pp.984-992
著者・共著者	Yamamoto Ryo†, Ueta Yoshifumi, Kato Nobuo*
担当区分	2nd著者
発行年月	2007/08
概要	The amygdala and dopaminergic innervation thereunto are considered to cooperatively regulate emotional states and behaviors. The present experiments examined effects of dopamine on lateral amygdala (LA) neuron excitability by whole cell recordings. Bath application of dopamine induced slow afterdepolarization (sADP). This sADP lasted for>5 s, and its magnitude varied in a concentration-dependent manner. Co-application of the D1 receptor antagonist SKF83566 reduced its amplitude. The D1 receptor agonist SKF38393, applied alone, induced sADP of a smaller amplitude. Induction of the full sADP required 5-HT(2) and noradrenalin alpha(1) receptor activation as well. D2 receptor activation or blockade did not affect sADP induction. The calcium channel blocker cadmium or intracellular calcium chelator bis-(o-aminophenoxy)-N,N,N',N' tetraacetic acid (BAPTA) blocked induction of the sADP, which was suggested to be triggered by calcium influx. Under voltage clamp, membrane conductance decreased at the peak of sADP current (I(sADP)). I(sADP) was suppressed by cesium included in pipettes. The I-V curve of the net I(sADP) was shifted as the external concentration of potassium was raised, and the reversal potential was identical to that of potassium, suggesting that dopamine decreases potassium conductance to induce the sADP. The present sADP may serve asa positive-feedback regulator of excitability in LA neurons.
DOI	10.1152/jn.00204.2007
文献番号	17553953
PMID	17553953