ウエタ　ヨシフミ   UETA Yoshifumi   植田　禎史    所属   医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differentiated participation of thalamocortical subnetworks in slow/spindle waves and desynchronization.
掲載誌名	正式名：The Journal of Neuroscience 略　 称：J Neurosci ISSNコード：1529-2401(Electronic)0270-6474(Linking)
巻・号・頁	32(5),pp.1730-1746
著者・共著者	Ushimaru Mika†, Ueta Yoshifumi, Kawaguchi Yasuo*
担当区分	2nd著者
発行年月	2012/02
概要	During sleep, the electroencephalogram exhibits synchronized slow waves that desynchronize when animals awaken [desynchronized states (DSs)]. During slow-wave states, the membrane potentials of cortical neurons oscillate between discrete depolarized states ("Up states") and periods of hyperpolarization ("Down states"). To determine the role of corticothalamic loops in generating Up/Down oscillations in rats, we recorded unit activities of layer 5 (L5) corticothalamic (CTh) cells in the frontal cortex, neurons in the thalamic reticular nucleus, and basal ganglia- and cerebellum-linked thalamic relay nuclei, while simultaneously monitoring the local cortical field potential to identify slow-wave/spindle oscillations and desynchronization. We found that (1) some basal ganglia-linked and reticular thalamic cells fire preferentially near the beginning of Up states; (2) thalamic cells fire more selectively at a given Up-state phase than do CTh cells; (3) CTh and thalamic cells exhibit different action potential timings within spindle cycles; and (4) neurons exhibit different firing characteristics when comparing their activity during Up states and DSs. These data demonstrate that cortico-thalamo-cortical subnetworks are temporally differentiated during slow and spindle oscillations, that the basal ganglia-linked thalamic nuclei are closely related with Up-state initiation, and that Up states and DSs are distinguished as different depolarization states of neurons within the network.
DOI	10.1523/JNEUROSCI.4883-11.2012
文献番号	22302813
PMID	22302813