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アシハラ キヨウミ
ASHIHARA Kiyoumi
芦原 京美 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Temporal analysis of regional strain rate during adenosine triphosphate stress before and after percutaneous coronary interventions. |
| 掲載誌名 | 正式名：Heart and vessels 略 称：Heart Vessels ISSNコード：09108327/16152573 |
| 掲載区分 | 国外 |
| 出版社 | Springer Japan |
| 巻・号・頁 | 30(3),pp.309-317 |
| 著者・共著者 | GUNJI Kazue, ATUSHI TAKAGI*, ARAI Kotaro, ASHIHARA Kyomi, Nobuhisa Hagiwara |
| 発行年月 | 2015/05 |
| 概要 | Regional myocardial ischemia is thought to be characterized by diastolic dysfunction. We aimed to clarify whether temporal analysis of strain rate (SR) index derived from two-dimensional speckle-tracking echocardiography (2DTE) can assess the regional myocardial ischemia or not. Forty-two patients with significant coronary stenoses were referred for percutaneous coronary intervention (PCI). 2DTE was performed before and a day after PCI. Time from aortic valve closure to peak early diastolic longitudinal SR ∆(TAVC-E SR) was measured both at baseline and during adenosine triphosphate (ATP) infusion. TAVC-E SR was calculated as TAVC-E SR during ATP infusion subtracted by TAVC-E SR at baseline. In forty-five target ischemic regions, TAVC-E SR at baseline was significantly longer than that of control regions (166 ± 28 vs. 136 ± 32 ms, P < 0.0001). TAVC-E SR in target ischemic regions significantly prolonged during ATP stress to 221 ± 37 ms (P < 0.0001), while it did not change in control regions. Immediately after PCI, TAVC-E SR in target regions significantly decreased to 135 ± 27 ms, P < 0.0001 without prolongation during ATP stress. Receiver operating characteristic curves demonstrated that ∆TAVC-E SR could assess regional myocardial ischemia by a cutoff criterion of 14 ms with sensitivity of 93% and specificity of 95%. 2DTE-derived TAVC-E SR significantly increased during ATP stress only in ischemic myocardium. This phenomenon disappeared immediately after PCI. Temporal analysis of TAVC-E SR appeared to be useful to assess the regional myocardial ischemia. |
| DOI | 10.1007/s00380-014-0491-x |
| PMID | 24633495 |