デグチ　アツコ   Deguchi Atsuko   出口　敦子    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Curcumin targets in inflammation and cancer.
掲載誌名	正式名：Endocrine, metabolic & immune disorders drug targets 略　 称：Endocr Metab Immune Disord Drug Targets ISSNコード：(2212-3873)1871-5303(Linking)
巻・号・頁	15(2),pp.88-96
著者・共著者	Deguchi Atsuko
担当区分	筆頭著者,責任著者
発行年月	2015
概要	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti-oxidant and anti-cancer activities. The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-κB and STAT3 signaling. Thus, curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases. Clinical trials have been ongoing or completed for various cancers, including breast, pancreatic and colorectal cancers, and multiple myeloma. In this review, the molecular mechanisms and the issue of bioavailability are mainly discussed.
PMID	25772169