マルヤマ　タカシ   MARUYAMA Takashi   丸山　隆志    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	その他
言語種別	英語
査読の有無	査読なし
表題	Spectroscopy and navigation
掲載誌名	正式名：J Neurosurg ISSNコード：00223085
巻・号・頁	102(2),pp.402-403
著者・共著者	CHERNOV Mikhail†, MURAGAKI Yoshihiro, OCHIAI Taku, MARUYAMA Takashi, IZAWA Masahiro, HAYASHI Motohiro, ONO Yuko, KUBO Osami, HORI Tomokatsu
発行年月	2005/03
概要	Object. It is often difficult to delineate the extent of invasion of high- and low-grade gliomas into normal brain tissue by using conventional T-1- and T-2-weighted magnetic resonance (MR) imaging. Knowledge of the relationship between the tumor infiltration zone and normal brain, however, is one of the prerequisites for performing as radical a tumor resection as possible. Proton MR spectroscopy allows noninvasive measurements of the concentrations and spatial distributions of brain metabolites and, therefore, may provide biochemical information in vivo, that is useful in distinguishing pathological from normal areas of the brain. The authors have developed a method to use the properties of MR spectroscopy to investigate intraoperatively pathological changes in the spatial distribution of choline (Cho)-containing compounds, total creatine, and N-acetyl-aspartate (NAA) in brain tumors with the aid of frameless stereotaxy. Methods. Maps of the Cho/NAA ratio were calculated and automatic segmentation of the tumors was performed. Spectroscopic images of the segmented tumor were matched to an anatomical three-dimensional (3D) MR imaging set by applying a fully automated mutual-information algorithm. The resulting 3D MR image can be used subsequently for neurosurgical planning, transfer to a frameless stereotactic system, and display in the navigation microscope during surgery leading to H-1-MR spectroscopy-guided navigation. Conclusions. This method may allow better intraoperative identification of tumor border zones based on metabolic changes due to tumor infiltration.
DOI	10.3171/jns.2005.102.2.0402
文献番号	15739576
PMID	15739576