イセキ　ヒロシ   Iseki Hiroshi   伊関　洋    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任顧問
論文種別	その他
言語種別	英語
査読の有無	査読あり
表題	A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection
掲載誌名	正式名：Med Image Comput Comput Assist Interv
掲載区分	国外
出版社	© Springer-Verlag Berlin Heidelberg 2006
巻・号・頁	9(Pt 1),pp.543-550
著者・共著者	NOGUCHI Masafumi †, AOKI Eisuke , YOSHIDA Daiki , KOBAYASHI Etsuko , OMORI Shigeru , MURAGAKI Yoshihiro, ISEKI Hiroshi, NAKAMURA Katsushige , SAKUMA Ichiro
発行年月	2006/02
概要	We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 microm close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.
文献番号	17354933