イセキ　ヒロシ   Iseki Hiroshi   伊関　洋    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任顧問
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Outcome after pituitary radiosurgery for thalamic pain syndrome
掲載誌名	正式名：Int J Radiat Oncol Biol Phys ISSNコード：03603016
巻・号・頁	69(3),pp.852-857
著者・共著者	HAYASHI Motohiro†, CHERNOV Mikhail, TAIRA Takaomi, OCHIAI Taku, NAKAYA Kotaro, TAMURA Noriko, GOTO Shinichi, YOMO Shoji, KOUYAMA Nobuo, KATAYAMA Yoko, KAWAKAMI Yoriko, IZAWA Masahiro, MURAGAKI Yoshihiro†, NAKAMURA Ryoichi, ISEKI Hiroshi, HORI Tomokatsu, TAKAKURA Kintomo
発行年月	2007/11
概要	To evaluate outcomes after pituitary radiosurgery in patients with post-stroke thalamic pain syndrome.|From 2002 to 2006, 24 patients with thalamic pain syndrome underwent pituitary radiosurgery at Tokyo Women's Medical University and were followed at least 12 months thereafter. The radiosurgical target was defined as the pituitary gland and its connection with the pituitary stalk. The maximum dose varied from 140 to 180 Gy. Mean follow-up after treatment was 35 months (range, 12-48 months).|Initial pain reduction, usually within 48 h after radiosurgery, was marked in 17 patients (71%). However, in the majority of cases the pain recurred within 6 months after treatment, and at the time of the last follow-up examination durable pain control was marked in only 5 patients (21%). Ten patients (42%) had treatment-associated side effects. Anterior pituitary abnormalities were marked in 8 cases and required hormonal replacement therapy in 3; transient diabetes insipidus was observed in 2 cases, transient hyponatremia in 1, and clinical deterioration due to increase of the numbness severity despite significant reduction of pain was seen once.|Pituitary radiosurgery for thalamic pain results in a high rate of initial efficacy and is accompanied by acceptable morbidity. It can be used as a primary minimally invasive management option for patients with post-stroke thalamic pain resistant to medical therapy. However, in the majority of cases pain recurrence occurs within 1 year after treatment.
DOI	10.1016/j.ijrobp.2007.04.043
文献番号	17570607