イセキ　ヒロシ   Iseki Hiroshi   伊関　洋    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任顧問
論文種別	その他
言語種別	英語
査読の有無	査読あり
表題	Combination of intraoperative 5-aminolevulinic acid-induced fluorescence and 3-D MR imaging for guidance of robotic laser ablation for precision neurosurgery
掲載誌名	正式名：Med Image Comput Comput Assist Interv
掲載区分	国外
出版社	Springer, Berlin, Heidelberg
巻・号・頁	11(Pt 2),pp.373-380
著者・共著者	LIAO Hongen†, SHIMAYA Koji , WANG Kaimeng , NOGUCHI Masafumi , MURAGAKI Yoshihiro, KOBAYASHI Etsuko , ISEKI Hiroshi, SAKUMA Ichiro
発行年月	2008/09
概要	A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.
DOI	doi.org/10.1007/978-3-540-85990-1_45
文献番号	18982627