ツカダ　ヒロコ   Tsukada Hiroko   塚田　弘子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Efficacy of lapatinib monotherapy on occult breast cancer presenting with cutaneous metastases: A case report.
掲載誌名	正式名：Oncology letters 略　 称：Oncol Lett ISSNコード：(1792-1074)1792-1074(Linking)
巻・号・頁	8(6),pp.2448-2452
著者・共著者	Noguchi Eiichiro, Kamio Takako*, Kamio Hidenori, Miura Hiroko, Tamaki Masako, Nishizawa Masako, Aoyama Kei, Oochi Tetsuya, Kameoka Shingo
発行年月	2014/12
概要	The case of a 72-year-old female who identified a lymph node enlargement in the left axilla is reported in the present study. A lymph node biopsy revealed a metastatic adenocarcinoma of the axillary lymph node. Following various assessments, the patient was diagnosed with occult breast cancer and lymph node metastases, for which treatment was initiated. Trastuzumab monotherapy was administered as the patient was elderly, positive for the hepatitis B virus and exhibited the following immunostaining/immunohistochemical analysis results: Estrogen receptor (ER) negative (-), progesterone receptor (PgR) negative (-) and human epidermal growth factor receptor 2 (HER2) positive (3+). Breast ultrasonography was performed 10 months after the initial trastuzumab administration and the left axillary lymph node enlargement had reduced in size and severity. However, a skin rash (erythema) was observed encompassing the left breast and extending into the axilla. As determined by the result of a skin biopsy of this area, the patient was diagnosed with occult breast cancer with cutaneous metastases. The immunohistochemical analysis results obtained from the skin biopsy were similar to those obtained from the lymph nodes: ER (-), PgR (-) and HER2 (3+). Therefore, the patient was switched from trastuzumab to lapatinib monotherapy. The erythema completely disappeared after two months of treatment. At present (34 months following lapatinib monotherapy initiation) no new lesions or severe side-effects have been observed.
DOI	10.3892/ol.2014.2594
PMID	25360168