イチハラ　アツヒロ   ICHIHARA Atsuhiro   市原　淳弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease.
掲載誌名	正式名：Clinical and experimental nephrology 略　 称：Clin Exp Nephrol ISSNコード：1437-7799(Electronic)1342-1751(Linking)
巻・号・頁	17(6),pp.848-56
著者・共著者	HAMADA Kazu, TANIGUCHI Yoshinori, SHIMAMURA Yoshiko, INOUE Kosuke, OGATA Koji, ISHIHARA Masayuki, HORINO Taro, FUJIMOTO Shimpei, OHGURO Takashi, YOSHIMOTO Yukio, IKEBE Mika, YUASA Kenji, HOSHINO Eri, IIYAMA Tatsuo, ICHIHARA Atsuhiro, TERADA Yoshio
発行年月	2013/12
概要	BACKGROUND:Prorenin, the precursor of renin, binds to the (pro)renin receptor [(P)RRBACKGROUND:]BACKGROUND:and triggers intracellular signaling. The ligand binding sites of (P)RR are disconnected and are present in the soluble form of the receptor in serum. Given that the clinical significance of serum prorenin and soluble (P)RR in chronic kidney disease (CKD) is unclear, we investigated the relationship between serum prorenin, soluble (P)RR, and various clinical parameters in patients with CKD.METHODS:A total of 374 patients with CKD were enrolled. Serum samples were collected, and the levels of soluble (P)RR and prorenin were measured using ELISA kits. Serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), hemoglobin (Hb), soluble secreted α-Klotho, and the urine protein/Cr ratio were also measured.
DOI	10.1007/s10157-013-0803-y
文献番号	23564382