イチハラ　アツヒロ   ICHIHARA Atsuhiro   市原　淳弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester.
掲載誌名	正式名：The Journal of clinical endocrinology and metabolism 略　 称：J Clin Endocrinol Metab ISSNコード：1945-7197(Electronic)0021-972X(Linking)
巻・号・頁	98(6),pp.2528-35
著者・共著者	WATANABE Noriyoshi†, MORIMOTO Satoshi, FUJIWARA Takeo, SUZUKI Tomo, TANIGUCHI Kosuke, MORI Fumiko, ANDO Takashi, WATANABE Daisuke, KIMURA Tadashi, SAGO Haruhiko, ICHIHARA Atsuhiro*
担当区分	責任著者
発行年月	2013/06
概要	CONTEXT:There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RRCONTEXT:]CONTEXT:may contribute to the development of GDM.OBJECTIVE:The objective of the study was to determine whether plasma s(P)RR concentrations during early pregnancy are associated with the development of GDM later in pregnancy.DESIGN, SETTING, AND PARTICIPANTS:This prospective cohort study was conducted at a referral birth center. Pregnant women who first visited our hospital during the first trimester (DESIGN, SETTING, AND PARTICIPANTS:<DESIGN, SETTING, AND PARTICIPANTS:14 weeks of gestation) between 2010 and 2011 were enrolled. Inclusion criteria included singleton pregnancy and the absence of preexisting diabetes mellitus. A total of 716 women participated in this study.MAIN OUTCOME MEASURE:The association of plasma s(P)RR concentrationsMAIN OUTCOME MEASURE:with the onset of GDM later in pregnancy was measured.RESULTS:Among 716 participants, 44 (6.1%) had GDM and 672 (93.9%) did not. There were 176 participants in the first plasma s(P)RR concentration quartile (Q1:RESULTS:<RESULTS:25.8 ng/mL), 179 in the second (Q2: 25.8-30.2 ng/mL), 181 in the third (Q3: 30.2-34.2 ng/mL), and 180 in the fourth (Q4:RESULTS:>RESULTS:34.2 ng/mL). GDM distribution was 7 (4.0%) in Q1, 5 (2.8%) in Q2, 13 (7.2%) in Q3, and 19 (10.6%) in Q4. A multivariate model adjusted for baseline characteristics, medical complications, and gestational characteristics revealed that the risk of developing GDM among women in Q4 compared with Q1 was 2.90 (95% confidence interval 1.11-7.49).CONCLUSION:Increased s(P)RR concentrations during the first trimester may predict the development of GDM later in pregnancy.
DOI	10.1210/jc.2012-4139
文献番号	23720787