イチハラ　アツヒロ   ICHIHARA Atsuhiro   市原　淳弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells.
掲載誌名	正式名：Hypertension research : official journal of the Japanese Society of Hypertension 略　 称：Hypertens Res ISSNコード：13484214(Electronic)09169636(Linking)
巻・号・頁	37(9),pp.830-5
著者・共著者	KURAUCHI-MITO Asako†, ICHIHARA Atsuhiro*, BOKUDA Kanako, SAKODA Mariyo, KINOUCHI Kenichiro, YAGUCHI Tomonori, YAMADA Taketo, SUN-WADA Ge-Hong, WADA Yoh, ITOH Hiroshi
担当区分	責任著者
発行年月	2014/05
概要	UNLABELLED:The (pro)renin receptor ((P)RR) is known to play an important role in the pathogenesis of vascular complications in diabetes mellitus and hypertension through its function in activating the local renin-angiotensin system. Recent studies have shown that the (P)RR is an accessory protein of the vacuolar H(+)-ATPase, suggesting a more fundamental and developmental function. In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascUNLABELLED:ular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H(+)-ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H(+)-ATPase.Hypertension Research advance online publication, 15 May 2014; doi:10.1038/hr.2014.92.
DOI	10.1038/hr.2014.92
PMID	24830537