ニツタ　マサユキ   Nitsuta Masayuki   新田　雅之    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors.
掲載誌名	正式名：Journal of neurosurgery 略　 称：J Neurosurg ISSNコード：00223085
巻・号・頁	119(4),pp.845-852
著者・共著者	MURAGAKI Yoshihiro†, AKIMOTO Jiro, MARUYAMA Takashi, ISEKI Hiroshi, IKUTA Soko, NITTA Masayuki, MAEBAYASHI Katsuya, SAITO Taichi, OKADAYoshikazu, KANEKO Sadao, MATSUMURA Akira, KUROIWA Toshihiko, KARASAWA Katsuyuki, NAKAZATO Yoichi, KAYAMA Takamasa
発行年月	2013/10
概要	The objective of the present study was to perform a prospective evaluation of the potential efficacy and safety of intraoperative photodynamic therapy (PDT) using talaporfin sodium and irradiation using a 664-nm semiconductor laser in patients with primary malignant parenchymal brain tumors.|In 27patients with suspected newly diagnosed or recurrent primary malignant parenchymal brain tumors, a single intravenous injection of talaporfin sodium (40 mg/m(2)) was administered 1 day before resection of the neoplasm. The next day after completion of the tumor removal, the residual lesion and/or resection cavity were irradiated using a 664-nm semiconductor laser with a radiation power density of 150 mW/cm(2) and a radiation energy density of 27 J/cm(2). The procedure was performed 22-27 hours after drug administration. The study cohort included 22 patients with a histopathologically confirmed diagnosis of primary malignant parenchymal brain tumor. Thirteen of these neoplasms (59.1%) were newly diagnosed glioblastomas multiforme (GBM).|Among all 22 patients included in the study cohort, the 12-month overall survival (OS), 6-month progression-free survival (PFS), and 6-month local PFS rates after surgery and PDT were 95.5%, 91%, and 91%, respectively. Among patients with newly diagnosed GBMs, all these parameters were 100%. Side effects on the skin, which could be attributable to the administration of talaporfin sodium, were noted in 7.4% of patients and included rash (2 cases), blister (1 case), and erythema (1 case). Skin photosensitivity test results were relatively mild and fully disappeared within 15 days after administration of photosensitizer in all patients.|Intraoperative PDT using talaporfin sodium and a semiconductor laser may be considered as a potentially effective and sufficiently safe option for adjuvant management of primary malignant parenchymal brain tumors. The inclusion of intraoperative PDT in a combined treatment strategy may have a positive impact on O
DOI	10.3171/2013.7.JNS13415.
PMID	23952800 [PubMed - indexed for MEDLINE]