サトウ　キヨウコ   Satou Kiyouko   佐藤　恭子    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effects of various doses of aspirin on platelet activity and endothelial function.
掲載誌名	正式名：Heart and vessels 略　 称：Heart Vessels ISSNコード：1615-2573(Electronic)0910-8327(Linking)
巻・号・頁	26(3),pp.267-73
著者・共著者	Furuno Takashi, Yamasaki Fumiyasu, Yokoyama Takeshi, Sato Kyoko, Sato Takayuki, Doi Yoshinori, Sugiura Tetsuro
発行年月	2011/05
概要	Although aspirin has become an established medicine for cardiac and cerebrovascular diseases, the optimal dose remains unknown. We evaluated the optimal dose of aspirin on platelet activity and endothelial function by administering 11 healthy male volunteers (32 ± 6 years of age) doses of aspirin that were increased in a stepwise manner (0, 81, 162, 330 and 660 mg/day) every 3 days. Platelet activity was assessed as surface P-selectin expression (%) measured by flow cytometry and the platelet aggregation ratio. Endothelial function in the brachial artery was assessed by measuring flow-mediated dilation (FMD) before and after reactive hyperemia. Platelet aggregation and P-selectin expression were significantly and dose-dependently suppressed (81-660 mg), and the FMD ratio tended to increase from 0 to 162 mg, but decreased significantly at 660 mg. In conclusion, although aspirin suppressed platelet activity and even surface P-selectin expression, higher doses worsened endothelial-mediated arterial dilation.
DOI	10.1007/s00380-010-0054-8
文献番号	21063876