イチハラ　アツヒロ   ICHIHARA Atsuhiro   市原　淳弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	[Regulatory mechanisms for the renin-angiotensin-aldosterone system].
掲載誌名	正式名：Nihon rinsho. Japanese journal of clinical medicine 略　 称：Nihon Rinsho ISSNコード：0047-1852(Print)0047-1852(Linking)
巻・号・頁	70(9),pp.1477-81
著者・共著者	ICHIHARA Atsuhiro
担当区分	筆頭著者
発行年月	2012/09
概要	While the circulating renin-angiotensin-aldosterone system(RAAS) plays an important role in the regulation of the sodium and extracellular fluid balance and blood pressure, the tissue RAAS has been reported to be involved in the pathophysiology of organ damage in patients with hypertension and diabetes. However, the regulation of the tissue RAAS, that is the production of angiotensin II and aldosterone within the tissue independently of the circulating RAAS, remains undetermined in detail. The purpose of this article is to review the recent advances in tissue RAAS research with a particular focus on the roles of (pro)renin receptor in the pathological conditions and its physiological function.
文献番号	23012790