ヒロシマ　ケンゾウ   HIROSHIMA Kenzou   廣島　健三    所属   医学部 医学科（附属八千代医療センター）    職種   登録医
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Significance of the correlation between the expression of interleukin 6 and clinical features in patients with non-small cell lung cancer.
掲載誌名	正式名：International journal of surgical pathology 略　 称：Int J Surg Pathol ISSNコード：1940-2465(Electronic)1066-8969(Linking)
巻・号・頁	20(3),pp.233-9
著者・共著者	Koh Eitetsu†, Iizasa Toshihiko, Yamaji Haruko, Sekine Yasuo, Hiroshima Kenzo, Yoshino Ichiro, Fujisawa Takehiko
発行年月	2012/06
概要	BACKGROUND:The aims of the study were to identify the significance of interleukin (IL)-6 production and to determine whether IL-6 production influences long-term survival in patients with non-small-cell lung cancer (NSCLC).METHOD:A series of 90 patients with NSCLC who underwent surgery between 2005 and 2007 was analyzed. Preoperative serum IL-6 was measured, and tumor samples were immunohistochemically stained for IL-6.RESULTS:Serum IL-6 levels were elevated in 43 of 90 cases (47.7%), and 23 (25.5%) of 90 cases stained positively for IL-6 (P = .00265). The prognosis of patients with NSCLC who had positive immunohistochemical staining was significantly worse than that for those who had negative staining, by univariate analysis (P = .0027). Multivariate analysis indicated that tumor size, postoperative stage, and overexpression of IL-6 were independent prognostic factors.CONCLUSIONS:The expression of IL-6 in tumor correlated with the concentration of serum IL-6, tumor progression, and overall survival in patients with NSCLC.
DOI	10.1177/1066896911436274
文献番号	22334615