イシザワ　カヤ   Ishizawa Kaya   石澤　香野    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Decreased response inhibition in middle-aged male patients with type 2 diabetes.
掲載誌名	正式名：BioPsychoSocial Medicine 略　 称：Biopsychosoc Med ISSNコード：1751-0759(Electronic)1-0759(Linking)
巻・号・頁	4(1),pp.1
著者・共著者	Ishizawa Kaya T, Kumano Hiroaki, Sato Atsushi, Sakura Hiroshi, Iwamoto Yasuhiko
担当区分	筆頭著者
発行年月	2010/05
概要	BACKGROUND:This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).METHODS:Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.RESULTS:Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.CONCLUSIONS:Our results showed that middle-aged, newly diagnosed and medication-free patients with typeCONCLUSIONS:2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.
DOI	10.1186/1751-0759-4-1
文献番号	20181219