ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Coincidence of central neurocytoma and multiple glioblastomas:a rare cace report
掲載誌名	正式名：J Neurooncol ISSNコード：1573-7373
巻・号・頁	93(3),pp.431-435
著者・共著者	MURAGAKI Yoshihiro†, CHERNOV Mikhail, Tajika Yasuhiko Tajika Yasuhiko, KUBO Osami, ISEKI Hiroshi, HORI Tomokatsu
担当区分	筆頭著者
発行年月	2009/07
概要	Epub 2009 Jan 29. Coincidence of parenchymal primary brain tumors of different histogenesis is extremely rare. To the best of our knowledge, the present case of simultaneous appearance of a central neurocytoma and multiple glioblastomas is the first to be reported. Multiple intraaxial brain neoplasms were disclosed in a 39-year-old man and were surgically resected. Histological diagnosis of the tumor located in the right lateral ventricle was central neurocytoma whereas two tumors of the left temporal lobe were glioblastomas. The latter were located in close proximity to the subarachnoid space, had atypical radiological appearance, and were slightly positive for synaptophysin and neurofilament protein. It can be speculated that both malignant neoplasms were, in fact, dedifferentiated central neurocytoma, which developed from distant tumor deposits. This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation. Better understanding of histogenesis of this tumor is definitely neede
DOI	10.1007/s11060-008-9793-0
PMID	19183852