タキタ　モリチカ   Takita Morichika   瀧田　守親    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Naringin suppresses, osteoclast formation and enhances bone mass in mice.
掲載誌名	正式名：Journal of Health Science 略　 称：J. Health Sci. ISSNコード：13449702/13475207
掲載区分	国内
出版社	Pharmaceutical Society of JAPAN
巻・号・頁	55(3),pp.463-467
著者・共著者	Hirata Michiko†, Matsumoto Chiho, Takita Morichika, Miyaura Chisato*, Inada Masaki
発行年月	2009/06
概要	Naringin is a flavonoid commonly found in citrus fruits. Previous studies have supported a positive association between fruit consumption and health including bone quality. To clarify the role of naringin in bone turnover, we examined the effect of naringin on bone mass in mice, and on osteoclast formation induced by bone-resorbing cytokine. When mice were orally administered naringin for 2 weeks, femoral bone mineral density (BMD) was clearly elevated compared with control mice. BMD in distal and middle portion was significantly enhanced, but proximal BMD was not changed by naringin administration. In soft-X-ray analysis, a marked accumulation of cancellous bone could be detected in distal femoral metasphysis in mice treated with naringin. In cocultures of bone marrow cells and osteoblasts, naringin dose-dependently suppressed the number of osteoclasts formed by treatment with interleukin-1 (IL-1). The size of osteoclasts formed in the presence of naringin was smaller than that induced by IL-1. Naringin enhances bone mass possibly by suppression of osteoclast formation in mice, suggesting the role of the citrus flavonoid on bone health and to prevent bone diseases such as osteoporosis.
DOI	http://doi.org/10.1248/jhs.55.463