イセキ　ヒロシ   Iseki Hiroshi   伊関　洋    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任顧問
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Localization of nerve fiber bundles by polarization-sensitive optical coherence tomography.
掲載誌名	正式名：Journal of neuroscience methods 略　 称：J Neurosci Methods ISSNコード：01650270
掲載区分	国外
出版社	Elsevier B.V.
巻・号・頁	174(1),pp.82-90
著者・共著者	NAKAJI Hiroshi†, KOUYAMA Nobuo, KAWAKAMI Yoriko, MURAGAKI Yoshihiro, ISEKI Hiroshi
担当区分	責任著者
発行年月	2008/09
概要	Diagnostic modalities that can distinguish brain tumors from eloquent cortices or nerve fiber bundles are important for neurosurgery. For identifying nerve fiber bundles, various techniques such as diffusion tensor imaging and subcortical stimulation mapping have been used. In this article, we propose localization of nerve fiber bundles by polarization-sensitive optical coherence tomography (PS-OCT) for the first time. PS-OCT performs tomographic imaging by measuring the travel distance and the change in polarization of the backscattered light from the tissue at different traverse positions, enabling selective visualization of birefringent tissues such as nerve fiber bundles. We examined the imaging of nerve fiber bundles in blocks of fixed rat brains. Nerve fiber bundles in internal and external capsules of the rat brains appearing on the surfaces of the coronal, horizontal, and sagittal planes were identified as to their locations and orientations. The nerve fiber bundles were clearly visualized by PS-OCT. The image penetration depth of the PS-OCT images was about 1.0 mm in gray matter and about 0.5 mm in white matter, so the refractive indices of gray and white matters were assumed to be 1.4.
DOI	10.1016/j.jneumeth.2008.07.004
PMID	18675301