カトウ　ヒデヒト   Katou Hidehito   加藤　秀人    所属   医学部 医学科    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	T cell activation in abnormal perinatal events
掲載誌名	正式名：Microbiology and Immunology ISSNコード：03855600
巻・号・頁	54(1),pp.38–45
著者・共著者	Matuda Yoshio, Kato Hidehito†, Imanishi Kenichi, Mitani Minoru, Ohota Hiroaki, Uchyama Takehiko
担当区分	筆頭著者,責任著者
発行年月	2010/01
概要	The aim of this study was to determine the percentage of CD45RO(+) T cells in umbilical cord blood from neonates born at less than 37 weeks of gestation. Fifty-nine patients were enrolled in this study, including 49 with preterm and 10 with term deliveries. Preterm deliveries were divided into two categories; spontaneous (Group A, n= 31) and indicated (Group B, n= 18). Perinatal infection was categorized as C-CAM, H-CAM and neonatal infection. The percentage of CD45RO(+) T cells in the umbilical cord was assessed using flow cytometry. IL-6 was measured using ELISA. In Group A, the percentage of CD45RO(+) T cells and concentrations of IL-6 in patients with perinatal infection (n= 18) were significantly higher than in those without perinatal infection (n= 13). A significant correlation between percentage of CD45RO(+) T cells and IL-6 concentrations was observed in the cord blood (r= 0.62, P= 0.001). In Group B, pink-tinged amniotic fluid was observed in seven cases. In these cases, an increase in the percentage of CD45RO(+) T cells (>10%) was noted. In the cases without perinatal infection, which included all those delivered at term (n= 32), no correlation was observed between the percentage of CD45RO(+) T cells and gestational age at delivery (r=-0.139, P= 0.448). We concluded that a high percentage of CD45RO(+) cord blood T cells is observed not only in perinatal infection, but also in the presence of abnormal perinatal events such as maternal bleeding in preterm gestation.