Faculty Information - Ootsuki Michio

（Last updated : 2024-08-04 16:41:47）

Ootsuki Michio
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Endocrinology

Position Professor and Division head

■ Books

Chapter contribution　

Estrogen actions and cardiovascular risk., McGRAW-HILL YEARBOOK OF Science & Technology 2004 2004

■ Published papers

1.	Review article	Diagnosis and management of adrenal incidentaloma: use of clinical judgment and evidence in dialog with the patient. 2023/12/13
2.	Case report	A Rare Case of Placental Abruption and Postpartum Compression Fractures in Pregnancy with Cushing Syndrome. 2023/11/16
3.	Original article	HSP47 levels determine the degree of body adiposity. 2023/11/11
4.	Original article	Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus formation is associated with decreased MEF2C-KLF2 pathway. 2022/11
5.	Original article	Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism. 2022/09
6.	Original article	ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors. 2022/08
7.	Original article	Ketone body 3-hydroxybutyrate enhances adipocyte function. 2022/06
8.	Original article	Lactate dehydrogenase regulates basal glucose uptake in adipocytes. 2022/06
9.	Original article	Plasma NfL is associated with mild cognitive decline in patients with diabetes. 2022/05
10.	Original article	Transforming growth factor β1 signaling links extracellular matrix remodeling to intracellular lipogenesis upon physiological feeding events. 2022/04
11.	Original article	Clinical guidelines for the diagnosis and treatment of 21-hydroxylase deficiency (2021 revision) 2022
12.	Original article	Sex Difference in the Association of Osteoporosis and Osteopenia Prevalence in Patients with Adrenal Adenoma and Different Degrees of Cortisol Excess. 2022
13.	Original article	Glutamine deficiency induces lipolysis in adipocytes. 2021/12/31
14.	Original article	Increased Dosage of MRA Improves BP and Urinary Albumin Excretion in Primary Aldosteronism With Suppressed Plasma Renin. 2021/11/19
15.	Original article	γENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity 2021/11/01
16.	Original article	Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With Coronavirus SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19 2021/10/06
17.	Case report	A Japanese patient with a 2p25.3 terminal deletion presented with early-onset obesity, intellectual disability and diabetes mellitus: A case report 2021/08/11
18.	Case report	Laparoscopic resection of aortocaval paraganglioma diagnosed by serial increase in urinary metanephrines after bilateral adrenalectomy in a patient with multiple endocrine neoplasia type 2A 2021/06/04
19.	Original article	Diverse pathological lesions of primary aldosteronism and their clinical significance 2021/05
20.	Case report	Debulking surgery for functional pleural dissemination of parathyroid carcinoma-case report 2021/04
21.	Original article	Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus 2021
22.	Original article	Characteristics of non-functioning pituitary adenomas that cause secondary adrenal insufficiency 2021
23.	Case report	Coincidence of Large Adrenal Cyst and Prominent Hyporeninemic Hyperaldosteronism 2021
24.	Original article	Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus 2020
25.	Original article	Basal Plasma Aldosterone Concentration Predicts Therapeutic Outcomes in Primary Aldosteronism 2020
26.	Original article	Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism 2020
27.	Case report	Endocrinological Features of Hartsfield Syndrome in an Adult Patient With a Novel Mutation of FGFR1 2020
28.	Original article	Metabolomic Analysis of Diet-Induced Obese Mice Supplemented with Eicosapentaenoic Acid 2020
29.	Original article	Nadir Aldosterone Levels After Confirmatory Tests Are Correlated With Left Ventricular Hypertrophy in Primary Aldosteronism 2020
30.	Case report	Oral Contraceptive Disturbedthe Recovery of the Adrenal Function after Adrenalectomy in Cushing Syndrome: A Case Report 2020
31.	Original article	Renal function is associated with blood neurofilament light chain level in older adults 2020
32.	Original article	Impact of adrenocorticotropic hormone stimulation during adrenal venous sampling on outcomes of primary aldosteronism. 2019/05
33.	Original article	Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple Mechanisms in Cushing Syndrome 2019
34.	Case report	Asymptomatic Pontine Lesion and Diabetic Amyotrophy after Rapid Improvement of Poor Glycemic Control in a Patient with Type 1 Diabetes 2019
35.	Original article	Clinical and biochemical outcomes after adrenalectomy and medical treatment in patients with unilateral primary aldosteronism 2019
36.	Original article	Clinical Characteristics of Acromegalic Patients With Paradoxical GH Response to Oral Glucose Load 2019
37.	Original article	Glucocorticoid Replacement Affects Serum Adiponectin Levels and HDL-C in Patients With Secondary Adrenal Insufficiency 2019
38.	Original article	High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan 2019
39.	Original article	Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan 2019
40.	Original article	Influence of antihypertensive drugs in the subtype diagnosis of primary aldosteronism by adrenal venous sampling 2019
41.	Original article	Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism 2019
42.	Review article	Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors: clinical guidelines of the Japan Endocrine Society 2019
43.	Case report	Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients 2019
44.	Original article	Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes 2019
45.	Case report	Rare case of Leydig cell tumor with type I diabetes mellitus causing female pattern hair loss 2019
46.	Original article	The number of positive confirmatory tests is associated with the clinical presentation and incidence of cardiovascular and cerebrovascular events in primary aldosteronism 2019
47.	Case report	A case of monoclonal gammopathy of undetermined significance with abnormal low levels of plasma glycated albumin by M protein. 2018/12
48.	Original article	Clinical Characteristics and Postoperative Outcomes of Primary Aldosteronism in the Elderly. 2018/10
49.	Original article	Correlation Between Lateralization Index of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism. 2018/08
50.	Original article	Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism 2018
51.	Original article	Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: A cross-sectional study 2018
52.	Original article	Evaluation of Hypothalamic–Pituitary–Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test 2018
53.	Original article	Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced obesity 2018
54.	Original article	Metabolomic and microarray analyses of adipose tissue of dapagliflozin-treated mice, and effects of 3-hydroxybutyrate on induction of adiponectin in adipocytes 2018
55.	Review article	New diagnostic criteria of adrenal subclinical Cushing's syndrome: opinion from the Japan Endocrine Society 2018
56.	Original article	Obesity as a Key Factor Underlying Idiopathic Hyperaldosteronism 2018
57.	Original article	Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway 2018
58.	Original article	Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan 2018
59.	Original article	SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes 2018
60.	Original article	Significance of Computed Tomography and Serum Potassium in Predicting Subtype Diagnosis of Primary Aldosteronism 2018
61.	Case report	Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy 2018
62.	Original article	TSH ratio as a novel diagnostic method for Cushing's syndrome 2018
63.	Original article	Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice 2017
64.	Case report	Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient 2017
65.	Original article	Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism 2017
66.	Original article	Regulation of Dipeptidyl Peptidase-4, its Substrate Chemokines, and Their Receptors in Adipose Tissue of ob/ob Mice 2017
67.	Original article	Saline Infusion Test highly associated with the incidence of cardio- and cerebrovascular events in primary aldosteronism 2017
68.	Case report	A case of glucocorticoid-induced diabetes in which the efficacy between sitagliptin and metformin was compared 2016
69.	Original article	Clinical and endocrinological characteristics of adrenal incidentaloma in Osaka region, Japan 2016
70.	Original article	Clinical significance of screening for subclinical Cushing's disease in patients with pituitary tumors 2016
71.	Review article	Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion] 2016
72.	Original article	Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells 2016
73.	Original article	Incompatibility between fasting and postprandial plasma glucose in patients with Cushing's syndrome 2016
74.	Original article	Nur77 gene expression levels were involved in different ACTH-secretion autonomy between Cushing's disease and subclinical Cushing's disease 2016
75.	Original article	Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients 2016
76.	Case report	Treatment of Mitochondrial Diabetes with a Peroxisome Proliferator-activated Receptor (PPAR)-gamma Agonist 2016
77.	Original article	Adipose tissue macrophages induce PPARgamma-high FOXP3(+) regulatory T cells 2015
78.	Original article	Clinical significance of fluctuations in thyroid hormones after surgery for Cushing's syndrome 2015
79.	Case report	Cytokine storm after cessation of tocilizumab in a patient with refractory Takayasu arteritis 2015
80.	Original article	Effects of growth hormone excess on glycated albumin concentrations: Analysis in acromegalic patients 2015
81.	Original article	Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in lipid accumulation 2015
82.	Original article	Postoperative changes in bone metabolism and bone mineral density in Japanese patients with acromegaly: a 3-year prospective study 2015
83.	Case report	Aniridia with a heterozygous PAX6 mutation in which the pituitary function was partially impaired 2014
84.	Original article	Gsp mutation in acromegaly and its influence on TRH-induced paradoxical GH response 2014
85.	Original article	Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery 2014
86.	Original article	Serum albumin-adjusted glycated albumin is an adequate indicator of glycemic control in patients with Cushing's syndrome 2014
87.	Original article	Sitagliptin Significantly Decreases the Ratio of Glycated Albumin to HbA1c in Patients with Type 2 Diabetes Mellitus 2014
88.	Case report	A Case of Hypocalcemia with Severe Vitamin D Deficiency following Treatment for Graves'Disease with Methimazole 2013
89.	Original article	Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway 2013
90.	Original article	Association of subclinical hypothalamic-pituitary-adrenal axis suppression with bone loss in patients with asthma taking inhaled corticosteroids 2013
91.	Original article	Dipeptidyl peptidase-4 inhibitors are effective in Japanese type 2 diabetic patients with sustained endogenous insulin-secreting capacity, a higher body mass index and insulin resistance 2013
92.	Case report	Exenatide alters absorption of hydrocortisone in a diabetic patient with panhypopituitarism: iatrogenic adrenal insufficiency 2013
93.	Original article	Expression of activating transcription factor 2 in inflammatory macrophages in obese adipose tissue 2013
94.	Original article	Glycated albumin is set lower in relation to plasma glucose levels in patients with Cushing's syndrome 2013
95.	Original article	Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone 2013
96.	Case report	Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling 2013
97.	Original article	Obstructive sleep apnea syndrome causes a pseudo-Cushing's state in Japanese obese patients with type 2 diabetes mellitus 2013
98.	Case report	Pseudohypoglycemia or hyperglycemia caused by interference with self-monitoring blood glucose measurements in anticancer ascorbic acid therapy 2013
99.	Case report	Serum vitamin D levels are decreased in patients without remission of Graves'disease 2013
100.	Original article	Study on the mechanism causing elevation of serum CA19-9 levels in diabetic patients 2013
101.	Original article	The temporary drop of serum octreotide concentration deteriorated ventricular tachycardia in an acromegalic patient 2013
102.	Original article	Tocilizumab for the treatment of patients with refractory Takayasu arteritis. 2013
103.	Case report	A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain 2012
104.	Case report	A case of long-standing autoimmune type 1 diabetes with common variable immunodeficiency 2012
105.	Original article	Biological characteristics of growth hormone-producing pituitary adenomas are different according to responsiveness to thyrotropin-releasing hormone 2012
106.	Case report	Large adrenal ganglioneuroma 2012
107.	Case report	Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves'disease 2012
108.	Case report	Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol 2012
109.	Original article	Association of urine acidification with visceral obesity and the metabolic syndrome 2011
110.	Original article	Evaluation of the glycated albumin/HbA1c ratio by stage of diabetic nephropathy 2011
111.	Case report	Right-sided acute suppurative thyroiditis caused by infectious endocarditis 2011
112.	Original article	Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus 2010
113.	Original article	Identification of a new secretory factor, CCDC3/Favine, in adipocytes and endothelial cells 2010
114.	Original article	Measurement of adiponectin production from differentiated metabolic stem cells 2010
115.	Original article	Reduced carotid atherosclerosis in asthmatic patients treated with inhaled corticosteroids 2010
116.	Original article	Effects of pitavastatin on serum lipids and high sensitivity C-reactive protein in type 2 diabetic patients 2009
117.	Original article	Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels 2009
118.	Original article	Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, alpha-subunit-like effector A 2008
119.	Case report	Painless thyroiditis occurring during post-menopausal period, following remission of Graves'disease 2008
120.	Original article	Independent association between insulin-like growth factor-I and dehydroepiandrosterone sulphate in women in middle adulthood 2007
121.	Original article	Menopause, but not age, is an independent risk factor for fasting plasma glucose levels in nondiabetic women 2007
122.	Original article	Negative association of obesity and its related chronic inflammation with serum glycated albumin but not glycated hemoglobin levels 2007
123.	Original article	Reduced epinephrine reserve in response to insulin-induced hypoglycemia in patients with pituitary adenoma 2007
124.	Original article	Atherosclerotic risk factors in Japanese subjects with isolated impaired fasting glucose and those with isolated impaired glucose tolerance according to 1997 and 2003 American Diabetes Association criteria 2006
125.	Original article	The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells 2006
126.	Original article	Regeneration of tubular complex is promoted by a free space 2005
127.	Original article	Sex differences of age-dependent changes of insulin sensitivity in Japanese nondiabetic subjects 2005
128.	Review article	Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus 2005
129.	Original article	Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue 2004
130.	Original article	Identification of a functional variant of estrogen receptor beta in an African population 2004
131.	Review article	Cardiovascular roles of estrogen receptors: insights gained from knockout models 2003
132.	Original article	Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus 2003
133.	Original article	Risk factors for asymptomatic atherosclerosis in Japanese type 2 diabetic patients without diabetic microvascular complications 2003
134.	Original article	Specific regulation of lipocalin-type prostaglandin D synthase in mouse heart by estrogen receptor beta 2003
135.	Case report	Impaired counter-regulation to hypoglycemia in a patient with stress. 2002
136.	Original article	RU486 antagonizes the inhibitory effect of peroxisome proliferator-activated receptor alpha on interleukin-6 production in vascular endothelial cells 2002
137.	Original article	Characterization of premature atherosclerosis of carotid arteries in acromegalic patients. 2001/06
138.	Original article	Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-kappaB binding to its recognition sequence 2001
139.	Original article	PPARalpha and GR differentially down-regulate the expression of nuclear factor-kappaB-responsive genes in vascular endothelial cells 2001
140.	Original article	Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells 2001
141.	Original article	Impaired beta-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients 2000
142.	Original article	Relationship between circulating vascular cell adhesion molecule-1 and microvascular complications in type 2 diabetes mellitus 1998
143.	Case report	A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide 1997
144.	Original article	Circulating vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic NIDDM patients 1997
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■ Academic conference presentation

1.	Increased dosage of Mineralocorticoid receptor antagonist improves blood pressure and urinary albumin excretion in primary aldosteronism with suppressed plasma renin. 2022/06/11
2.	Diabetes Mellitus Is the Risk Factor of Cardiovascular and Cerebrovascular Events in Primary Aldosteronism. 2020/03/28
3.	The possibility of therapeutic use of glucocorticoids for atherosclerosis. 2012/11/15
4.	The effect of raloxifene on bone, glucose and lipid metabolisms in postmenopausal asthmatic women treated with inhaled corticosteroids. 2010/03/26
5.	Glucocorticoids-Induced Down-Regulation of Glucocorticoid Receptor Is Associated with Glucocorticoid Resistance in Vascular Endothelial Cells. 2007/06/02
6.	Estrogen induces lipocalin-type prostaglandin D synthase gene expression in mouse heart. 2002/06/19
7.	Progesterone inhibits TNFα-induced vascular cell adhesion molecule-1 expression in vascular endothelial cells. 1999/06/12
8.	Circulating vascular cell adhesion molecule-1 as a useful marker for atherosclerosis in NIDDM patients. 1997/07/22
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■ Research areas

Metabolism and endocrinology (Key Word：Endocrinology)

■ Education

1986/04～1992/03

Faculty of Medicine, Yamagata University, Graduated, M.D., Ph.D.

■ Academic & professional experience

1.	2020/08～2021/06	Osaka University Graduate School of Medicine Department of Metabolic Medicine Associate Professor
2.	2011/05～2020/07	Osaka University Department of Metabolic Medicine Lecturer
3.	2007/09～2011/04	Osaka University Graduate School of Medicine Department of Metabolic Medicine Assistant Professor
4.	2000/08～2003/09	Karolinska Institutet Department of Biosciences at Novum Guest Researcher, Researcher
5.	1998/10～2000/07	Osaka University Medical School Department of Medicine III
6.	1992/06～1992/11	Osaka University Medical School Department of Medicine III
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