Faculty Information - HIRAI Toshihito

（Last updated : 2025-03-19 14:47:54）

HIRAI Toshihito
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Urology

Position Associate Professor

■ Published papers

1.	Original article	Outcomes of kidney transplantation in recipients with SARS-cov-2 infection: a 282-case single-center experience in Japan. 2025/02
2.	Original article	Unveiling spatial immune cell profile in kidney allograft rejections using 36-plex immunofluorescence imaging. 2024/12
3.	Original article	Renal outcome of living kidney donors aged more than 70 years. 2024/09
4.	Original article	Variations of vascular reconstruction in kidney transplantation with multiple renal graft arteries . 2024/06/11
5.	Original article	Comparison of estimated blood loss during living kidney transplantation according to the number of double-filtration plasmapheresis. 2024/04/14
6.	Original article	Safety of docetaxel in a patient with metastatic castration-resistant prostate cancer after kidney transplantation: A case report. 2024/04
7.	Original article	The medical cost and outcome of desensitization protocol in kidney transplantation recipients with high immunological risks. 2024/04
8.	Original article	Higher donor age and severe microvascular inflammation are risk factors for chronic rejection after treatment of active antibody-mediated rejection. 2024/02
9.	Original article	Clinical course of candidate renal tansplant recipients diagnosed with prostate cancer during pre-transplant screening test. 2024/01
10.	Original article	En bloc kidney transplantation from pediatric donors to teenage recipients: Two case reports. 2023/12/27
11.	Original article	Kidney transplantation after multiple urinary tract conversion with an ileal conduit: A case report. 2023/05/14
12.	Original article	Pregnancy complications and impact on kidney allograft after kidney transplantation in IgA nephropathy. 2023/05/04
13.	Original article	Analysis of the T-cell repertoire and transcriptome identifies mechanisms of regulatory T-cell suppression of GVHD. 2023/04/06
14.	Original article	Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo. 2023/03/16
15.	Original article	IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. 2022/12
16.	Original article	Role of fractalkine-CX3CR1 axis in acute rejection of mouse heart allografts subjected to ischemia reperfusion injury 2022/02/01
17.	Original article	Allogeneic CAR invariant natural killer T cells exert potent antitumor effects through host CD8 T-cell cross-priming. 2021/11/01
18.	Original article	Invariant natural killer T-cell subsets have diverse graft-versus-host-disease-preventing and antitumor effects. 2021/09/09
19.	Original article	Imaging alloreactive T cells provides early warning of organ transplant rejection. 2021/07/08
20.	Original article	Activation of natural killer T cells enhances the function of regulatory T-cell therapy in suppressing murine GVHD. 2021/06/08
21.	Original article	Influence of a low-dose tacrolimus protocol on the appearance of de novo donor-specific antibodies during 7 years of follow-up after renal transplantation. 2021/06
22.	Original article	Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance 2021/04/15
23.	Original article	Molecular imaging of chimeric antigen receptor T cells by ICOS-ImmunoPET. 2021/02
24.	Original article	Infusion of host-derived unlicensed NK cells improves donor engraftment in non-myeloablative allogeneic hematopoietic cell transplantation. 2021/01/07
25.	Original article	Influence of a low-dose tacrolimus protocol on the appearance of de novo donor-specific antibodies during 7-years of follow-up after renal transplantation. 2020/12
26.	Original article	Visualization of activated T cells by OX40-ImmunoPET as a strategy for diagnosis of acute graft-versus-host disease. 2020/11
27.	Other	Combination therapy of iNKT cell ligand and CD40-CD154 signal blockade establishes islet allograft acceptance in non-myeloablative bone marrow transplant recipients. 2019/05
28.	Original article	Evaluation of the impact of conventional immunosuppressant on the establishment of murine transplantation tolerance - an experimental study. 2019/04
29.	Other	Combination therapy of iNKT cell ligand and CD40-CD154 signal blockade establishes islet allograft acceptance in non-myeloablative bone marrow transplant recipients. 2019/01/31
30.	Original article	iNKT cell activation plus T-cell transfer establishes complete chimerism in a murine sublethal bone marrow transplant model. 2018/02
31.	Original article	Preemptive kidney transplantation: a propensity score matched cohort study. 2017/12
32.	Original article	Evaluation of microvascular inflammation in ABO-incompatible kidney transplantation. 2017/06
33.	Original article	Donor bone marrow cells are essential for iNKT cell-mediated Foxp3+ Treg cell expansion in a murine model of transplantation tolerance. 2017/04
34.	Original article	Transitional B cells predominantly reconstituted after a desensitization therapy using rituximab before kidney transplantation. 2017/04
35.	Original article	Diabetes mellitus after kidney transplantation in Japanese patients:The Japan Academic Consortium of Kidney Transplantation study. 2017/03
36.	Original article	Assessment of 4 cases of kidney transplantation from hepatitis C virus antibody-positive and RNA-negative donors to antibody-negative recipients. 2016/09
37.	Original article	Association between body mass index and outcomes in Japanese living kidney transplant recipients: The role of sex differences. 2016/09
38.	Original article	Post-transplant lymphoproliferative disorder in kidney transplant recipients: A single-center experience in Japan. 2016/04
39.	Original article	Clonal deletion established via invariant NKT cell activation and costimulatory blockade requires in vivo expansion of regulatory T cells. 2016/02
40.	Original article	Retroperitoneoscopic donor nephrectomy with multiple renal arteries does not affect graft survival and ureteral complications. 2014/12
41.	Other	The phenotype of repopulating B cell after rituximab therapy in kidney transplant patients. 2014/11
42.	Original article	Influence of dialysis duration on the outcome of living kidney transplantation. 2014/10
43.	Original article	Analysis of predictive and preventive factors for de novo DSA in kidney transplant recipients. 2014/08
44.	Other	The authors' reply 2014/08
45.	Original article	A Novel Approach Inducing Transplant Tolerance by Activated Invariant Natural Killer T Cells With Costimulatory Blockade 2014/03
46.	Original article	Influence of Dialysis Duration on the Outcome of Living Kidney Transplantation 2014/02
47.	Original article	Impact of right-sided nephrectomy on long-term outcomes in retroperitoneoscopic live donor nephrectomy at single center 2013/10
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■ Academic conference presentation

1.	Validity of automatic diagnosis system for transplant kidney pathology : Comparison with diagnosis by pathologist. 2024/11/16
2.	L-2 receptor engineering and treg cell. 2024/11/15
3.	Optimization of a model for predicting renal function after living kidney transplantation using CT volumetry. 2024/11/15
4.	Relationship between Parenchymal Stiffness and Renal Fibrosis in Kidney Transplant Recipients 2024/10/24
5.	Discordance between banff automation system and pathologists in diagnosing chronic antibody-mediated rejection in clinical practice. 2024/06/04
6.	Spatial transcriptomic analysis uncovers gene expression profiles in peritubular capillaritis in antibody-mediated rejection. 2024/06/03
7.	Predicting short-term outcomes of living kidney donor by machine learning. 2024/06/01
8.	Prediction of 10-yr renal graft survival of deceased donors based on preoperative data using machine learning. 2024/06/01
9.	The association between parenchymal stiffness and renal allograft fibrosis in kidney transplant recipients. 2024/06/01
10.	Clinical course of candidate renal transplant recipients diagnosed with prostate cancer during pre-transplant screening test. 2024/04/27
11.	Optimization of immunosuppressive therapy after kidney transplantation through machine learning. 2024/04/26
12.	Prediction of 10-yr renal graft survival of deceased donors based on preoperative data using machine learning. 2024/04/25
13.	The potential of donor-derived-cell-free DNA for rejection diagnosis in Japanese cohort. 2024/04/25
14.	Validity of automatic diagnosis system for transplant kidney pathology : Comparison with diagnosis by pathologist. 2024/04/25
15.	Urology beyond Europe - Joint Session of the European Association of Urology (EAU) and the Japanese Urological Association (JUA) 2024/04/05
16.	Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection. 2023/08/26
17.	Engineered IL-2 plus calcineurin inhibitor synergistically expands regulatory t cells transduced with engineered IL-2 receptor and facilitates establishment of transplantation tolerance. 2023/08/26
18.	Assessing long-term complications of kidney transplantation without intraoperative ureteral dj stent: A single-center experience. 2023/06/06
19.	Elderly living kidney transplant donors and their renal prognosis. 2023/06/06
20.	The outcome of kidney transplantation after cancer treatment in the patient with high estimated cure rate. 2023/06/06
21.	Donor-derived cell-free DNA analysis is capable of detecting antibody-mediated rejection in one-year biopsy of living kidney transplantation. 2023/06/05
22.	Safety and efficacy of hypoxia-inducible factor prolyl hydroxylase inhibitor in kidney transplant patients with post-transplant anemia. 2023/06/05
23.	Effects and side effects of desensitization therapy in flow cytometry crossmatch-negative, Low-dose donor-specific antibody-positive renal transplant recipients. 2023/06/04
24.	Impact of current desensitization protocols and surgical outcomes in ABO-incompatible kidney transplant recipients: A Japanese single-center experience. 2023/06/04
25.	Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection. 2023/06/03
26.	Outcomes of kidney transplantation recipients with Covid-19 infection : 282 Cases of a Single-Center experience. 2023/06/03
27.	The long-term renal outcome and pregnancy complications with kidney transplantation of IgA nephropathy. 2023/06/03
28.	The long-term renal outcome and pregnancy complications with kidney transplantation of IgA nephropathy. 2023/06/03
29.	Initial experiences of robot-assisted adrenalectomy. 2023/04/22
30.	Postoperative management of renal transplantation: what you need to know. 2023/04/21
31.	CODEX multiplex immune-staining Identifies novel spatial indexes for antibody-mediated rejection diagnosis. 2023/04/20
32.	Donor-derived cell-free DNA analysis is capable of detecting antibody-mediated rejection in one-year biopsy of kidney allograft. 2023/04/20
33.	Cost effectiveness of kidney transplantation in high-immunological risk patients in a Japan cohort. 2022/11/26
34.	IL-2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor. 2022/11/26
35.	Outcomes of ABO-compatible living kidney transplantation recipients with low immunological risk. 2022/11/26
36.	Outcomes of kidney transplantation recipients with SARS-CoV-2 infection: A single-center experience. 2022/11/26
37.	Outcomes of treatments for acute antibody-mediated rejection after kidney transplantation. 2022/11/26
38.	A case of kidney transplantation after multiple urinary tract conversion with an ileal conduit. 2022/11/25
39.	En bloc kidney transplant from pediatric donors to teenage recipients: A single-center experience. 2022/11/25
40.	Evaluation of cases of cytomegalovirus infection after renal transplantation at our department. 2022/11/25
41.	Preconception care and pregnancy complications after kidney transplantation: A single-center study. 2022/11/25
42.	Recurrence of cancer in 188 kidney transplant recipients. 2022/11/25
43.	Engineered IL-2 plus calcineurin inhibitor synergistically expands regulatory T cells transduced with engineered IL-2 receptor and facilitates establishment of transplantation tolerance. 2022/06/06
44.	Imaging alloreactive T cells provides early warning of organ transplant rejection. 2021/12/09
45.	Imaging OX40+alloreactive T cells provides early warning of organ transplant rejection. 2020/05/30
46.	Orthogonal IL-2 cytokine-receptor pair capable of selective expansion of regulatory T cells facilitates alloengraftment. 2020/05/30
47.	A novel method for ex vivo treg expansion via human iNKT cell activation. 2019/06/04
48.	Fractalkine is crucial in ischemia reperfusion injury related to acute rejection in an allogeneic heart transplantation model. 2019/06/02
49.	Cardiovascular Disease in Japanese kidney transplant recipients. 2017/05/02
50.	Once-daily versus twice-daily tacrolimus in living kidney transplantation: A Multicenter, parallel group, open-label, 5-year, randomized non-inferiority trial. 2017/05/02
51.	Renal transplantation to the extraperitoneal cavity in children weighing less than 15 kg can be performed safely. 2017/05/02
52.	A novel method for iNKT cell-mediated ex vivo treg expansion applied to induce human transplant tolerance. 2017/05/01
53.	CD40/CD40 ligand signal controls cytotoxic ability of natural killer cells after invariant natural killer T cell stimulation. 2017/05/01
54.	Combination therapy of iNKT cell ligand and CD40-CD154 signal blockade establishes islet allograft tolerance in non-myeloablative bone marrow transplant recipients. 2017/05/01
55.	iNKT cell activation plus veto cell transfer yields complete chimerismin a murine sub-lethal bone marrow transplant model. 2017/04/29
56.	CD40/CD40 ligand signal controls cytotoxic ability of natural killer cells after invariant natural killer T cell stimulation. 2016/12/06
57.	Combination of veto cell transfer and NKT cell therapy helps establish complete hematopoietic chimerism in non-myeloablative BMT recipients. 2016/12/06
58.	In vitro stimulation of human/murine iNKT cells activates regulatory T cell through IL-2 production. 2016/12/06
59.	Islet allografts survive permanently by inducing hematopoietic chimerism by activating invariant natural killer T cells under CD40-CD154 signal blockade. 2016/12/06
60.	ABO-incompatible living kidney transplantation at multicenter Japanese case series: Evolution of outcomes and immunosuppressive management. 2016/10/29
61.	Post-transplant diabetes mellitus after kidney transplantation in Japanese patients: The Japan Academic Consortium of Kidney Transplantation study. 2016/08/23
62.	Combination of veto cell transfer and iNKT cell therapy establishes complete hematopoietic chimerism in nonmyeloablative BMT recipients. 2016/08/20
63.	Comparison of the pharmacokinetics and pathology for low-dose once-daily and twice-daily tacrolimus following living kidney transplantation: Five-year results from a prospective trial. 2016/08/20
64.	Contrasting effects of tacrolimus and everolimus on regulatory T cell activation and mixed hematopoietic chimerism induced by natural killer T cell stimulation. 2016/08/20
65.	Preemptive kidney transplantation in Japanese patients: A propensity score-matched study. 2016/08/20
66.	Relationship between dialysis duration and prevalence of cardiovascular diseases in kidney transplantation recipients. 2016/08/20
67.	Combination of veto cell transfer and iNKT cell therapy establishes complete hematopoietic chimerism in non-myeloablative BMT recipients. 2016/06/14
68.	Contrasting effects of tacrolimus and everolimus on regulatory T cell activation and mixed hematopoietic chimerism induced by natural Killer T cell stimulation. 2016/06/14
69.	iNKT cell ligands administered with bone marrow cells expand allo-specific regulatory T cells in vivo and establish Transplant Tolerance. 2016/06/14
70.	Pharmakokinetics of prolonged-release formulation of tacrolimus:Comparison of AUC0-24 and concentration at 10 time points. 2016/06/13
71.	Relationship between dialisys duration and prevalence of cardiovascular diseases in kidney transplantation recipients. 2016/06/13
72.	The significance of microvascular inflammation in antibody-mediated rejection in ABO-incompatible kidney transplantation. 2016/06/13
73.	iNKT cell activation under co-stimulatory blockade establishes mixed chimerism through thymic regulatory T cell activation. 2016/06/12
74.	ABO-incompatible living kidney transplantation at multicenter Japanese case series: evolution of outcomes and immunosuppressive management. 2016/06/11
75.	Association between pretransplant body mass index and outcomes in patients undergoing living kidney transplantation: A consideration of gender differences. 2016/06/11
76.	iNKT cell activation establishes transplant tolerance though the orchestration of regulatory and deletional mechanism. 2016/04/23
77.	Induction of Acquired Cardiac Transplant Tolerance Through Natural Killer T-Cell Activation 2015/11/10
78.	Regulatory T cells expanded by activated iNKT cells facilitate migration of donor dendritic cells into the recipient thymus and subsequent establishment of clonal deletion. 2015/05/04
79.	The effect of rituximab therapy on regulatory B cell and prevention of chronic antibody mediated rejection in kidney transplantation recipients. 2015/05/04
80.	T cell transfer with iNKT cell activation facilitate engraftment of bone marrow cells without GvHD. 2015/05/03
81.	Donor specific tolerance can be induced by donor bone marrow transfer with activation of invariant naturel killer T cells. 2015/05/02
82.	A novel approach inducing transplant tolerance by activated invariant natural killer T cells with co-stimulatory blockade. 2014/07/29
83.	Analysis of predictive and preventive factors for de novo DSA in Non-HLA sensitized kidney transplant recipients. 2014/07/29
84.	Outcomes of pure retroperitoneoscopic live donor nephrectomy (RPLDN): single center experience of 764 cases. 2014/07/29
85.	Outcomes of retroperitoneoscopic live donor nephrectomy in patients with renal artery aneurysm. 2014/07/29
86.	Retroperitoneoscopic procurement of kidneys with multiple renal arteries does not affect graft survival and ureteral complications. 2014/07/29
87.	The correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression including rituximab. 2014/07/29
88.	Changes in ABO-blood type antibody titers after single-dose rituximab administration. 2014/07/27
89.	Long-term outcomes of living donor kidney transplantation in flow cytometry crossmatch-positive patients: A single-center experience. 2014/07/27
90.	The Signifi cance of Low Level DSA Detected by Solid Phase Assay in Association with Acute and Chronic Antibody Mediated Rejection 2012/06/05
91.	Long-Term Follow-Up of Kidney Transplant Recipient with Calcineurin Inhibitor-Associated Nephrotoxicity 2012/06/03
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■ Research areas

Urology, Immunology, Transplant immunology (Key Word：Transplantation tolerance)

■ Education

1.	2009/04～2014/06	〔Doctoral course〕 Integrative Cancer Therapy and Urology, Graduate School, Division of Medical Sciences, Kanazawa University, Completed, Doctor of Philosophy in Medical Science
2.	1997/04～2003/03	Medicine, Faculty of Medicine, Kanazawa University, Graduated,