Faculty Information - Furukawa Tooru

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Published papers

Academic conference presentation

Research grants & projects

Research areas

Awards & honors

Patents

Academic society memberships

Education

Academic & professional experience

（Last updated : 2022-02-16 16:14:52）

Furukawa Tooru
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Visiting Professor

■ Books

1.	Chapter contribution	Cystic tumor of the pancreas「新膵臓病学」 2017/02
2.	Chapter contribution	Histological subclassification and its clinical significance., Intraductal Papillary Mucinous Neoplasm of the Pancreas 2014/01
3.	Chapter contribution	Intraductal neoplasms of the exocrine pancreas., WHO Classification of Tumours of the Digestive System 2010/11
4.	Chapter contribution	Cystic neoplasms of the pancreas. Pathological aspects., Disease of the pancreas 2008
5.	Chapter contribution	Targeting targets of MAPK to treat cancer., Future aspects of medical sciences and education "Chalenge of integrated medical sciences." 2007
6.	Chapter contribution	The Role of DUSP6/MKP-3 in Pancreatic Carcinoma., Handbook of immunohistochemistry and in situ hybridization of human carcinomas 2005
7.	Chapter contribution	Genetic alterations in human pancreatic cancer., Carcinoma of the pancreas and biliary tract. 1998
8.	Chapter contribution	Genetic alterations in human pancreatic cancer., Recent Advances in Gastroenterological Carcinogenesis I. 1996
9.	Chapter contribution	Morphiological and molecular studies of atypical cells in the pancreatic duct give support to multistep carcinogenesis in the human pancreas., Recent Advances in Gastroenterological Carcinogenesis I. 1996
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■ Published papers

1.	Original article	Comparison of patients with invasive intraductal papillary mucinous carcinoma and invasive ductal carcinoma of the pancreas: a pathological type- and stage-matched analysis. 2019/11
2.	Original article	Evaluation of preoperative risk factors for postpancreatectomy hemorrhage. 2019/10
3.	Original article	Surgical Outcomes for Perihilar Cholangiocarcinoma with Vascular Invasion. 2019/07
4.	Original article	Evaluation of preoperative prognostic factors in patients with resectable pancreatic ductal adenocarcinoma. 2019/06
5.	Original article	Near-Comprehensive Resequencing of Cancer-Associated Genes in Surgically Resected Metastatic Liver Tumors of Gastric Cancer. 2019/04
6.	Original article	Diagnosis by 64-Row Multidetector Computed Tomography for Longitudinal Superficial Extension of Distal Cholangiocarcinoma. 2019/03
7.	Original article	Surgery in node-positive gallbladder cancer: The implication of an involved superior retro-pancreatic lymph node. 2019/03
8.	Case report	Somatic mutations and increased lymphangiogenesis observed in a rare case of intramucosal gastric carcinoma with lymph node metastasis. 2018/02
9.	Case report	A case of long-survival insulinoma with multiple neuroendocline tumour type 1 controlled by multimodal therapy. 2017/12
10.	Original article	Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. 2017/12
11.	Original article	ENBD is Associated with Decreased Tumor Dissemination Compared to PTBD in Perihilar Cholangiocarcinoma. 2017/09
12.	Original article	High-grade dysplasia/carcinoma in situ of the bile duct margin in patients with surgically resected node-negative perihilar cholangiocarcinoma is associated with poor survival: a retrospective study. 2017/08
13.	Original article	A primary tumor of mixed histological type is a novel poor prognostic factor for patients undergoing resection of liver metastasis from gastric cancer. 2017/05
14.	Review article	Familial pancreatic cancer: Concept, management and issues. 2017/02
15.	Original article	The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma. 2017/02
16.	Case report	A long-term recurrence-free survival of a patient with the mixed adeno-neuroendocrine bile duct carcinoma: A case report and review of the literature. 2017
17.	Review article	History and consensus of pathology of IPMN 2016/12
18.	Original article	Germline mutations in Japanese familial pancreatic cancer patients. 2016/10
19.	Original article	Specific MAPK-associated microRNAs in serum differentiate pancreatic cancer from autoimmune pancreatitis 2016/07
20.	Case report	Intracystic papillary neoplasm with an associated mucinous adenocarcinoma arising in Rokitansky-Aschoff sinus of the gallbladder. 2016/06
21.	Original article	GNAS^R201H and Kras^G12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm. 2016/05
22.	Original article	Original scientific reports: Clinicopathological findings of remnant pancreatic cancers in survivors following curative resections of pancreatic cancers. 2016/04
23.	Original article	Genomic sequencing identifies ELF3 as a driver of ampullary carcinoma. 2016/02
24.	Review article	Development of a genetically engineered mouse model of intraductal papillary mucinous neoplasm of the pancreas with the conditional expression of GNASR^201H 2016/01
25.	Original article	Improved surgical outocomes for hilar cholangiocarcinoma:changes in surgical procedures and related outocomes based on 40 years of Experience at a single intitution 2016/01
26.	Original article	Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: Recommendations of Verona consensus meeting. 2016/01
27.	Original article	A revised classification system and recommendations from the Baltimore consensus meeting for neoplastic precursor lesions in the pancreas. 2015/11
28.	Original article	Molecular biomarkers for progression of intraductal papillary mucinous neoplasm of the pancreas. 2015/03
29.	Review article	Pathology of the pancreatic cancer 2015/03
30.	Original article	Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. 2015/03
31.	Original article	Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas. 2015/02
32.	Review article	Impacts of activation of the mitogen-activated protein kinase pathway in pancreatic cancer. 2015/02
33.	Original article	Single nucleotide variations in CLCN6 identified in patients with benign partial epilepsies in infancy and/or febrile seizures. 2015
34.	Original article	Surgical Approaches to Advanced Gallbladder Cancer A 40-Year Single-Institution Study of Prognotic Factors and Resectability 2014/12
35.	Review article	Clinical relevance of frozen diagnosis of ductal margins in surgery of bile duct cancer. 2014/07
36.	Original article	Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". 2014/07
37.	Original article	Clinical and pathological features of solid pseudopapillary neoplasms of the pancreas at a single institution. 2014/06
38.	Original article	Identification of commensal flora-associated antigen as a pathogenetic factor of autoimmune pancreatitis 2014/03
39.	Original article	GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes. 2014/02
40.	Original article	Whole-exome sequencing identifies a de novo TUBA1A mutation in a patient with sporadic malformations of cortical development: a case report. 2014
41.	Review article	Subtypes and molecular pathology of IPMN 2013/11
42.	Original article	The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. 2013/11
43.	Review article	Biomarker of the pancreatic cancer 2013/09
44.	Original article	Clinical importance of familial pancreatic cancer registry in Japan: a report from kick-off meeting at international symposium on pancreas cancer 2012. 2013/08
45.	Original article	Distinctive histopathological findings of pancreatic hamartomas suggesting their "hamartomatous" nature: A study of 9 cases. 2013/07
46.	Review article	Pathology of familial pancreatic cancer 2013/07
47.	Original article	Usefulness of cell block cytology for preoperative grading and typing of intraductal papillary mucinous neoplasms 2013
48.	Original article	Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells. 2012/12
49.	Original article	Transrepression activity of T-box1 in a gene regulation network in mouse cells. 2012/12
50.	Original article	Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth. 2012/11
51.	Original article	Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation. 2012/11
52.	Original article	Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. 2012/02
53.	Original article	MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer. 2012/02
54.	Original article	Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. 2011/12
55.	Original article	Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. 2011/11
56.	Original article	Molecular characteristics and biological behaviors of the oncocytic and pancreatobiliary subtypes of intraductal papillary mucinous neoplasms. 2011/04
57.	Original article	Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. 2011/04
58.	Original article	Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1. 2011
59.	Original article	Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. 2011
60.	Original article	A mouse model of autoimmune pancreatitis with salivary gland involvement triggered by innate immunity via persistent exposure to avirulent bacteria. 2010/12
61.	Case report	A Case of Solid Pseudopapillary Neoplasm of the Pancreas Presenting with Left-sided Extrahepatic Portal Hypertension 2010/08
62.	Original article	A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines. 2010
63.	Original article	Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas 2010
64.	Original article	Blockade of DLL4 signaling inhibits both growth and angiogenesis of pancreatic cancer. 2010
65.	Original article	Duodenum-preserving total pancreatectomy for pancreatic neoplasms. 2010
66.	Original article	Non-invasive and minimally invasive intraductal papillary mucinous neoplasms of the pancreas. 2010
67.	Original article	Prognostic Relevance of Ductal Margins in Surgery of Bile Duct Cancer. 2010
68.	Original article	Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma. 2010
69.	Original article	A Case of Insulinoma with Six Islet Cell Tumors Associated with Severe Hypoglycemia 2009
70.	Original article	Duodenum-preserving total pancreatectomy for pancreatic neoplasms 2009
71.	Case report	Insulinoma with six islet cell tumors associated with severe hypoglycemia. 2009
72.	Case report	Insulinoma with six Islet Cell Tumors Assosiated with Severe Hypolycemia 2009
73.	Case report	Intraductal tubular carcinoma of the pancreas: case report with molecular analysis. 2009
74.	Original article	Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. 2009
75.	Original article	Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. 2009
76.	Review article	Molecular pathology of pancreatic cancer: Implications for molecular targeting therapy 2009
77.	Original article	RNA Interference Targeting against S100A4 Suppresses Cell Growth and Motility and Induces Apoptosis in Human Pancreatic Cancer Cells. 2009
78.	Original article	Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer. 2009
79.	Original article	Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells. 2008
80.	Original article	Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. 2008
81.	Review article	Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside. 2008
82.	Original article	Synchronous and metachronous extra-pancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. 2008
83.	Original article	The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer. 2008
84.	Original article	Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas. 2007
85.	Original article	Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis. 2007
86.	Case report	Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreaticoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. 2007
87.	Review article	Molecular genetics of intraductal papillary-mucinous neoplasms. 2007
88.	Original article	Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. 2007
89.	Original article	AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. 2006
90.	Original article	Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. 2006
91.	Review article	Molecular mechanisms of pancreatic carcinogenesis. 2006
92.	Original article	Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. 2006
93.	Original article	PTOV1: a novel testosterone-induced atherogenic gene in human aorta. 2006
94.	Original article	Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. 2005
95.	Original article	Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. 2005
96.	Original article	Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas. 2005
97.	Original article	Infrequent Mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1. 2005
98.	Original article	RNA interference targeting aurora kinase A suppresses tumor growth and enhances the Taxane chemosensitivity in human pancreatic cancer cells. 2005
99.	Original article	An illustrated consensus on the classification of pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs). 2004
100.	Original article	Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor suppressor gene that suppresses angiogenesis. 2004
101.	Original article	Cystic neoplasm of the pancreas: A Japanese multiinstitutional study of intraductal papillary mucious tumor and mucinous cystic tumor. 2004
102.	Original article	DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. 2004
103.	Original article	E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. 2004
104.	Original article	Functional analysis of chromosome 18 in pancreatic cancer: Strong evidence for new tumor suppressor genes. 2004
105.	Review article	Molecular pathology of pancreatic cancer: In quest of tumor suppressor genes. 2004
106.	Review article	The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma. 2004
107.	Original article	TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. 2004
108.	Original article	APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line. 2003
109.	Original article	Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. 2003
110.	Original article	Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. 2003
111.	Original article	Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. 2003
112.	Original article	Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. 2002
113.	Original article	Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. 2001
114.	Original article	Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. 2001
115.	Original article	Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal adenocarcinoma. 2001
116.	Original article	Human BAC contig covering the deleted region in pancreatic cancer at 12q21. 2001
117.	Original article	Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. 2001
118.	Original article	RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. 2001
119.	Original article	Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. 2000
120.	Original article	Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability. 2000
121.	Original article	p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1. 2000
122.	Original article	Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer. 1999
123.	Original article	Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas. 1999
124.	Original article	Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1, 4-N-acetylglucosaminyltransferase IV- homologue (hGnT-IV-H) gene. 1999
125.	Original article	Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22- q24.1 in human pancreatic ductal adenocarcinoma. 1999
126.	Original article	Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer. 1999
127.	Original article	Infrequent somatic mutations of the p73 gene in various human cancers. 1999
128.	Original article	Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. 1999
129.	Case report	Thymic carcinoid in the pancreas: metastatic disease or new primary tumours. 1999
130.	Original article	Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic cancer. 1998
131.	Original article	Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. 1998
132.	Original article	Identification of a 100-kb region of common allelic loss on chromosome bands 10q25-q26 in human endometrial cancer. 1998
133.	Original article	Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer. 1998
134.	Original article	Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis. 1998
135.	Original article	The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. 1998
136.	Original article	The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia. 1998
137.	Original article	Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma. 1997
138.	Original article	PTEN1 is frequently mutated in primary endometrial carcinomas. 1997
139.	Original article	Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. 1996
140.	Original article	Computer-assisted pathology of intraepithelial adenocarcinoma and related lesions: 3-D distribution, structual aberration and discrimination. 1995
141.	Original article	Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. 1995
142.	Original article	Varying grades of epithelial atypia in the pancreatic ducts of humans. 1994
143.	Original article	Reproducible categorization of atypia in pancratic duct epithelia based on morphometry and cluster analysis, correlating with CEA-positive reactions and Ki-ras gene alterations. 1993
144.	Original article	The mucus-hypersecreting tumor of the pancreas. Development and extension visualized by three-dimensional computerized mapping. 1992
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■ Academic conference presentation

1.	Is It Significant for Surgical Treatment for Gallbladdercancer with jaunfdice? 2019/09/04
2.	肝門部胆管癌患者における左三区域切除(Left trisectionectomy in patients with perihilar cholangiocarcinoma) 2019/06/13
3.	The analysis of resected cases of masquerading cholangiocarcinoma 2017/06/17
4.	Aprimary tumor of mixed histological type is a novel poor prognostic factor for patients undergoing resection of liver metastasis from gastric cancer 2017/06/07
5.	Curative operation for unresectable pancreas head cancer after chemotherapy in a patient 2017/06/07
6.	Is the short term surgery outcome of right hepatectomy for perihilar cholangiocarcinoma improved? 2017/06/07
7.	Left hepatectomy with right hepatic artery resection and reconstruction for intrahepatic cholangiocarcinoma in a patient 2017/06/07
8.	Neuroendcrine carcinoma of the extrahepatic bile duct 2017/06/07
9.	Risk of malignancy and pathological study of malignant neoplasms in autoimmune pancreatitis patients 2017/02/15
10.	Issues Related to the Diagnosis of Pancreatic Neuroendocrine Tumors in Routine Clinical Practice 2016/11/02
11.	Lymphaplasmacytic sclerosing pancreatitis coexisting with pancreatic intraepithelial neoplasia in the pancreas; Case report 2016/11/02
12.	HIGH-GRADE PANIN/CARCINOMA IN SITU OF THE PANCREAS ASSOCIATED WITH CYSTIC CHANGES AND FIBROSIS. 2016/10/27
13.	INVASIVE SIZE PREDICTS RECURRENCE AND SURVIVAL OF SMALL INVASIVE CARCINOMA ARISING IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM OF THE PANCREAS. 2016/10/27
14.	Subtype classification of IPMN and its impact on patient care. 2016/10/26
15.	(Symposium 27 Pancreatectomy : Safety and long-term results)Pancreatectomy: Safety and lonf-term results 2016/10/23
16.	A Case of Bening Schwannoma Arising from Never Plexus around the Common Hepatic Artery 2016/10/23
17.	A Long-trem survivor after combined resection of adjacent oregans in trestment for aciner cell carcinoma of the pancreas 2016/10/23
18.	Japanese familial pancreatic cancer 2016/10/06
19.	Impacts of a mutated GNAS on clinicopathology of intraductal papillary mucinous neoplasms of the pancreas. 2016/08/06
20.	International consensus for pathological evaluation of intraductal papillary mucinous neoplasm of the pancreas 2016/05/12
21.	Uncovering of a causal gene of intraductal papillary mucinous neoplasm of the pancreas 2016/04/22
22.	Verification of the Utility of International Consensus Guidelines 2012 for the Management of IPMN and MCN of the Pancreas 2015/11/04
23.	AJCC cancer staging system for bile duct carcinomas 2015/08/24
24.	Classofication of biliary trct cancers established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery : 3(rd) English edition 2015/08/24
25.	Hepatoid adenocarcinoma of the gallbladder in a patient 2015/06/20
26.	Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versussurgery-first for resectable pancreatic carcer (Prep-02/JSAP05). 2015/05/29
27.	Commensal flora would be silently involved in the pathogenesis of autoimmune pancreatitis and associated diseases 2015/04/24
28.	Could microorganisms-originated adjuvant be a triggering factor of IgG-related disease? 2015/04/24
29.	GNAS^R201H and Kras^G12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm. 2015/04/20
30.	Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas: Recommendations of Verona Consensus Meeting. 2015/03/23
31.	Revised recommendations for assessing precursor lesions in the pancreas. 2015/03/23
32.	Whole Exome Sequencing Uncovered Unexpected Recurrent Mutations in BRCA2 and FAT in Pancreatic Acinar Cell Carcinoma 2014/11/06
33.	Increased Risk of Pancreatic Cancer in Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas and Family History or Past History of Cancer of Pancreas or Other Organs 2014/11/05
34.	Commensal flora as a pathogenic factor of autoimmune pancreatitis and associated diseases 2014/10/22
35.	Extra-pancreatic involvement in repeated Escherichia coli inoculated mice harboring AIP-like pancreatitis 2014/10/22
36.	Intraductal neoplasms of the pancreas. 2014/09/20
37.	Somatic mutations of RNF43 are associated with its aberrant expression and GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. 2014/06/27
38.	A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms changes mucin gene expression and gene expression profiles. 2014/04/08
39.	Somatic mutations and aberrant expression of RNF43 are recurrently found in intraductal papillary mucinous neoplasms of the pancreas. 2014/04/08
40.	International consensus guideline 2012 for the management of IPMN and MCN of the pancreas is useful for the manegement of the branch duct IPMN -Analysis of the 363 resected cases- 2014/03/22
41.	Analysis of a commensal baceria triggered autoimmune pancreatitis mouse model 2014/02/16
42.	Treatment difficulty to the postoperative neocrotizing fasciitis of the abdominal wall:A case report 2013/12/05
43.	Mutation of GNAS found in IPMN induces alteration of gene expression profiles with promotion of mucin gene expression. 2013/10/04
44.	The treatment strategy of non-functioning pancreatic neuroendocrine tumor 2013/09/04
45.	Treatment difficulty to the postoperative necrotizing fasciitis of the adbdominal wall:Acase report 2013/06/15
46.	Surgery strategy for the branch duct IPMN of the pancreas 2013/03/27
47.	Intraductal tubulopapillary neoplasms do not evolve from intraductal tubular adenomas of the pancreas. 2013/03/16
48.	International consensus study on the terminology and diagnosis of tumoral intraepithelial neoplasms ("Adenomas" and "Intracystic papillary neoplasms" of WHO-2010) of the gallbladder 2013/03/06
49.	Molecular comparison between intraductal tubulopapillary neoplasms and intraductal tubular adenomas of the pancreas indicates their distinctive nature. 2013/03/05
50.	Clinical relevance of frozen diagnosis of ductal margins in surgery of bile duct cancer. 2013/02/08
51.	Clinicopathological Significance of Molecular aberations in G-protein Coupled Receptor Pathway in Intraductal Papillary Mucinous Neoplasms of the Pancreas 2012/10/31
52.	Does Duodenum-Preserivng Pancreatectomy Prevent Sever Postoperative Fatty Liver? 2012/10/31
53.	Surgical Management for IPMN of the pancreas 2012/10/31
54.	The Long-Term Survivors After Curative Resection for the Pancreatic Cancer Shuld Be Paid Attention to the Remnant Pancreatic Cancer 2012/10/31
55.	Usefulness of Cell Block Cytology for Preoperative Grading and Typing og IPMN 2012/10/31
56.	Pathology of familial pancreatic cancer. 2012/10/04
57.	Whole exome sequencing identifiesCUL9 as a MODY-X gene 2012/10/02
58.	Aberrant G-protein coupled receptor signaling pathway in interaductal papillary mucinous neoplasms of tha pancreas 2012/09/19
59.	Whole exome sequencing of acinar cell carcinoma of the pancreas 2012/09/11
60.	A Case of Chyluria, a Rare Complication after surgery for Cancer of the Galladder 2012/07/01
61.	A case of spindle call carcinoma of the hilar bile duct 2012/07/01
62.	Clinical analysis of the treatment for the remnant pancreas after pancreatectomy for IPMN of the pancreas 2012/07/01
63.	Indication of the limited pancreatic resection for cystic neoplasms of the pancreas 2012/07/01
64.	Surgical management for brabch duct IPMN of the pancreas 2012/07/01
65.	Surgical treatment for the lung metastasus from the Pancreatic cencer 2012/07/01
66.	Intraductal tumor of the pancreas 2011/11/16
67.	(Recent Adovance for IPMN and MCN and Various Tumors of the Pancreas)Surgical atrategy for IPMN of the pancreas 2011/11/09
68.	Intraductal papillary mucinous neoplasm(IPMN) in a patient with pamcreas divisum;Report of a case 2011/11/09
69.	Multiple insulinomas of the pancreas with lymph node metastases which occurred 21 years later from first oparation;Reprot of a case 2011/11/09
70.	Usefulness of the intraoperative transarterial embolization (IOTAE) of the splenic artery for the pancreatic diseasea associating with the maeked perigastric varices;Report of two cases 2011/11/09
71.	Aberrant signaling pathways in prodression of intraductal papillary mucinous neoplasms of the panceas 2011/10/03
72.	Whole exome sequencing of intraductal papillary mucinous neoplasm of the pancreas 2011/10/03
73.	Duodenum,bilisry tract and spleen preserving total pancreatectomy for pancreatic neoplasms 2011/08/28
74.	Whole exome sequencing of intraductal papillary mucinous neoplasm of the pancreas. 2011/07/12
75.	A mouse model of autoimmune pancreatitis with salivary gland involvement triggered by innate immunity via the persistent exposure of avirulent bacteria 2010/08
76.	SON is a novel therapeutic target for pancreatic cancer. 2010/04/17
77.	Invasive ductal adenocarcinoma with multiple intraductal dysplastic lesions in the pancreas: A case presentation. 2009/12/05
78.	Molecular pathology of pancreatic cancer: Implications to molecular targeting. 2009/11/04
79.	Prognostic relevance of morphologic types of intraductal papillary mucinous neoplasms of the pancreas. 2009/11/04
80.	Pancreatic carcinogenesis: Mechanisms and implications for diagnosis and therapy. 2009/08/01
81.	Molecular pathology of pancreatic cancer: Implications to molecular targeting therapy. 2009/05/07
82.	Transcriptional Regulation of DUSP6 in a Feedback Loop Manner Responding to MAPK1 via ETS2 in Human Cells 2009/04/18
83.	Targeting targets of MAPK to treat pancreatic cancer. 2009/03/28
84.	Identification of therapeutic molecular targets for pancreatic cancer. 2008/10/28
85.	Targeting downstream targets of MAPK to treat pancreatic cancer. 2008/04/15
86.	Characteristic clinicopathological phenotypes of the types of intraductal papillary-mucinous neoplasm of the pancreas-a Japanese multi-institutional study. 2008/03/04
87.	Intraductal neoplasm of the pancreas developed in a 35-year-old woman. 2007/10/13
88.	Identification of novel molecular targets for diagnosis and treatment of pancreatic Cancer 2007/09/22
89.	Identification of novel therapeutic molecular targets for pancreatic cancer 2007/04/14
90.	Targeting targets of MAPK to treat cancer. 2006/12/03
91.	Cystic lesions of the pancreas-subtypes and gene alterations in IPMN 2006/11/26
92.	Clinicopathological significance of types of intraductal papillary-mucinous neoplasms of the pancreas 2006/09/16
93.	AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. 2006/04/01
94.	Elucidation of downstream targets of MAPK1/ERK2 in pancreatic cancer 2005/04/16
95.	Pathology and nomenclature consensus in humans and mice. Pathology consultants. 2004/12/01
96.	Image and molecular analysis of precursor lesions: Three-tiered system or two-tiered system? 2004/07/11
97.	Roles of DUSP6/MKP-3 in pancreatic carcinogenesis. 2004/01/26
98.	Classification of varying atypical epithelium in the pancreatic duct based on morphometry and multivariate cluster analysis, which is related with molecular alterations. 2003/08/18
99.	Adenovirus mediated transfer of DUSP6 induces growth suppression and apoptosis in the pancreatic cancer cells. 2002/04/06
100.	Diagnostic and prognostic relevance of chromosome abnormalities in pancreatic cancer. 2000/04/01
101.	Identification of candidate tumor suppressor genes on chromosome arms 6q and 12q which are frequently deleted in human pancreatic cancer. 1999/04/10
102.	Ferequent allelic losses on chromosome arms 6q and 12q in human pancreatic cancer. 1998/07/13
103.	Identification of common deleted regions in chromosome arms 6q and 12q in human pancreatic cancer. 1998/03/28
104.	Gene alterations in human pancreatic cancer: identification of common deleted regions in chromosomes 6q and 12q. 1997/10/15
105.	Morphometrical and molecular studies of atypioal cells in the pancreatic duct give support to multistep carcinogenesis in the human pancreas. 1996/10/30
106.	Morphometrical and molecular studies of atypical cancer cells in the pancreatic duct give support to multistep carcinogenesis in the human pancreas. 1996/10/22
107.	Established normal human pancreatic ductal epithelial cell lines. 1995/11/02
108.	Paracrine and autocrine activities of hepatocyte growth factor in pancreatic ductal cells. 1995/05
109.	Paracrine and autocrine activities of hepatocyte growth factor in pancreatic ductal cells. 1995/03
110.	Hepatocyte growth factor and its receptor expression in carcinoma of the pancreas correlated with overall survival of the patients. 1994/11/02
111.	Mucoepidermoid carcinoma of the pancreas-Presentation of a case 1990/08/23
112.	The mucin-producing tumor of the pancreas-Its development and extension visualized by 3-D computerized mapping 1990/08/21
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■ Research grants & projects

2014/12～2015/12

BRCA mutations in pancreatic cancer in Japanese cohort. (Key Word : )

■ Research areas

Human pathology, Experimental pathology, Medical biochemistry, Digestive surgery (Key Word：cancer, oncology)

■ Awards & honors

1.	1991/08	Poster Award of International Association of Pancreatology
2.	1992/08	Poster Award of 22nd Annual Meeting of Japan Pancreas Society
3.	1994/09	Government of Canada Award
4.	2008/11	The Hirshberg Award for Pancreatic Cancer Research

■ Patents

2013/10/08

Composition for treatment of pancreatic cancer

■ Academic society memberships

1.		American Association for Cancer Research
2.		International Academy of Pathology
3.		International Association of Pancreatology
4.		Japan Pancreas Society
5.		Japanese Association of Cancer Research
6.		Japanese Society of Gastroenterology
7.		Japanese Society of Human Genetics
8.		Japanese Society of Molecular Biology
9.		Japanese Society of Pathology
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■ Education

1.	1993/02 Degree Acquisition	Tohoku University, PhD
2.	1980/04～1986/03	Faculty of Medicine, Akita University, Graduated, Doctor of Medicine

■ Academic & professional experience

1.	2010/04～	Tokyo Women's Medical University Institute for Integrated Medical Sciences Professor
2.	2008/04～2010/03	Tokyo Women's Medical University International Research and Educational Institute for Integrated Medical Sciences Professor
3.	2005/12～2008/03	Tokyo Women's Medical University International Research and Educational Institute for Integrated Medical Sciences Associate Professor
4.	1996/07～2005/11	Tohoku University School of Medicine First Department of Pathology Assistant Professor
5.	1995/09～1996/06	Tohoku Uinversity Hospital Department of Surgical Pathology
6.	1993/08～1995/08	Montreal General Hospital Research Institute Research Fellow
7.	1988/04～1993/07	Tohoku Uinversity Hospital
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