Faculty Information - Yoshina Sawako

（Last updated : 2025-04-22 17:28:15）

Yoshina Sawako
Department Center for Medical and Nursing Education, Center for Medical and Nursing Education Center for Medical and Nursing Education Division of Basic Sciences

Position Assistant Professor

■ Books

Single work　

ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif, 9), Atlas of Genetics and Cytogenetics in Oncology and Haematology 2013/12

■ Published papers

1.	Original article	Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi. 2023/10
2.	Original article	Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals. 2021/04
3.	Original article	Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level andATP production in Caenorhabditis elegans 2020/02
4.	Original article	Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model. 2019/03
5.	Original article	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase is indispensable for oogenesis, oocyte-to-embryo transition, and larval development of the nematode Caenorhabditis elegans. 2019/02
6.	Original article	The small GTPase ARF-1.2 is a regulator of unicellular tube formation in Caenorhabditis elegans. 2019/01
7.	Original article	Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy. 2018/06
8.	Case report	Somatic mutations and increased lymphangiogenesis observed in a rare case of intramucosal gastric carcinoma with lymph node metastasis. 2018/02
9.	Original article	An Aneuploidy-Free and Structurally Defined Balancer Chromosome Toolkit for Caenorhabditis elegans. 2018/01
10.	Original article	Novel deletion alleles of a C. elegans gene C38D4.9, named as tm4476 and tm4561. 2017/10
11.	Original article	Novel deletion alleles of a C. elegans gene Y48E1C.1, named as tm5468, tm5625 and tm5626. 2017/10
12.	Original article	Novel deletion alleles of a C. elegans gene Y73E7A.1, named as tm6429 and tm6475. 2017/10
13.	Original article	Cysteine protease cathepsin B mediates radiation-induced bystander effects. 2017/07
14.	Original article	Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans. 2016/11
15.	Original article	Engineering new balancer chromosomes in C. elegans via CRISPR/Cas9 2016/09
16.	Original article	Inhibition of the integrin signal constitutes a mouse iPS cell niche 2016/09
17.	Original article	Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line. 2016/07
18.	Original article	Curcumin improves tau-induced neuronal dysfunction of nematodes. 2016/03
19.	Original article	Locus-specific integration of extrachromosomal transgenes in C. elegans with the CRISPR/Cas9 system 2016/03
20.	Original article	Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. 2015/10
21.	Original article	Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. 2015/07
22.	Original article	RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. 2015/01
23.	Original article	The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans 2015/01
24.	Original article	The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. 2015/01
25.	Original article	A Conditional Knockout Toolkit for Caenorhabditis elegans Based on the Cre/loxP Recombination. 2014/12
26.	Original article	PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. 2014/09
27.	Original article	Methods for single/low-copy integration by ultraviolet and trimethylpsoralen treatment in Caenorhabditis elegans. 2014/08
28.	Original article	The homologous carboxyl-terminal domains of microtubule-associated protein 2 and Tau induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. 2014/02
29.	Original article	Characterization of PUD-1 and PUD-2, Two Proteins Up-Regulated in a Long-Lived daf-2 Mutant 2013/06
30.	Original article	Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants. 2013/04
31.	Original article	Large scale screening for targeted knockouts in the C. elegans genome. 2012/11
32.	Original article	Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. 2012/05
33.	Original article	RNA surveillance is required for endoplasmic reticulum homeostasis 2012/05
34.	Original article	Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method. 2012/01
35.	Original article	Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans. 2010/08
36.	Original article	EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. 2010/07
37.	Original article	Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. 2009/01
38.	Original article	A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. 2008/10
39.	Original article	Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. 2008/10
40.	Original article	An efficient transgenic system by TA cloning vectors and RNAi for C. elegans. 2006/11
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■ Academic conference presentation

1.	Elucidation of Factors Affecting Freeze-Thaw Tolerance in C. elegans 2023/06/24
2.	Regulation of aging by balancing mitochondrial function and antioxidant levels. 2023/03/15
3.	Elucidation of the molecular mechanism underlying freezing tolerance in C. elegans 2022/12/02
4.	Genetic balancer chromosomes created by CRISPR-mediated genome editing in C. elegans 2022/11
5.	The role of the GON Domain on IP3R and calcium homeostasis 2021/03/29
6.	Molecular mechanism of the GON domain in maintaining calcium balance 2020/03/18
7.	Analysis of the mechanism of action of bcl-7,the subunit of SWI/SNF complexes. 2019/08/22
8.	Molecular network search for bcl-7 related factors. 2019/03/30
9.	Analysis of Molecular and Cellular Roles of the GON domain in ER-to-Golgi transport 2019/03/29
10.	Balancer chromosome toolkit for C. elegans. 2017/06/21
11.	Genetic engineering of chromosomal balancer toolkit for gene-clusters mediated by CRISPR/Cas9 in Caenorhabditis elegans 2016/06/25
12.	Analysis of the mechanism of type 2 diabetes involving ADAMTS9 /GON-1 2015/11
13.	Risk of gene deletion in worms with impaired DNA repair machinery. 2015/06/27
14.	Genetic engineering of new balancers using by CRISPR/Cas9 genome-editing system in C. elegans 2015/06/24
15.	ADAMTS9 is involved in the development of type 2 diabetes. 2014/06/12
16.	RNA Surveillance is Required for Endoplasmic Reticulum Homeostasis. 2012/09/01
17.	RNA surveillance is required for endoplasmic reticulum homeostasis 2012/06/12
18.	Comprehensive RNAi analysis for discovery of novel UPR-associated genes. 2010/12
19.	Systematic isolation of mutants defective in transcription factors in C. elegans. 2009/07
20.	EAK-7 is a novel and conserved protein that modulates activity of the FoxO transcription factor DAF-16. 2007/06
21.	Functional analysis of C. elegans proteases in ER stress response. 2007/06
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■ Education

2004/04～2007/03

〔Doctoral course〕, Tokyo University of Pharmacy and Life Science, Completed,