Faculty Information - Sekine Hidekazu

Books

Published papers

Academic conference presentation

Research areas

Awards & honors

Academic society memberships

Education

Academic & professional experience

Rsearch funding number

（Last updated : 2024-11-12 11:26:47）

Sekine Hidekazu
Department Graduate School of Medical Science, Graduate School of Medical Science

Position Associate Professor

■ Books

1.	Chapter contribution	Organ Bioluminescence Imaging Under Machine Perfusion Setting for Assessing Quality of Harvested Organ Preservation, Methods in molecular biology, Bioluminescence: Methods and Protocols 2022/07/15
2.	Chapter contribution	Tubular Cardiac Tissue Bioengineered from Multi-Layered Cell Sheets for Use in the Treatment of Heart Failure, Methods in Molecular Biology 2022/05/27
3.	Chapter contribution	Cell Sheets for Cardiac Tissue Engineering, Organ tissue engineering 2020/05/13
4.	Chapter contribution	Cell Sheet Tissue Engineering for Heart Failure, Etiology and Morphogenesis of Congenital Heart Disease 2016/06
5.	Chapter contribution	Organ-Like Tissue Fabrication, Myocardial Tissue Engineering 2015/02
6.	Chapter contribution	Cell sheet technology for cardiac tissue engineering, Methods in Molecular Biology (Cardiac Tissue Engineering) 2014/06
7.	Chapter contribution	Cell Sheet Technology for Myocardial Tissue Engineering., Cardiovascular Regeneration Theraputics Using Tissue Engineering Approaches. 2005
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■ Published papers

1.	Original article	SNRK regulates TGFβ levels in atria to control cardiac fibrosis 2024/09/26
2.	Original article	Exploration of Preservation Methods for Utilizing Porcine Fetal-Organ-Derived Cells in Regenerative Medicine Research. 2024/01/25
3.	Original article	Successful reconstruction of the rat ureter by a syngeneic collagen tube with a cardiomyocyte sheet. 2023/12
4.	Original article	The bioengineering of perfusable endocrine tissue with anastomosable blood vessels. 2023/08
5.	Original article	Networked lymphatic endothelial cells in a transplanted cell sheet contribute to form functional lymphatic vessels. 2022/12/15
6.	Original article	External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion 2022/12/13
7.	Original article	Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues 2022/09/29
8.	Original article	Perfusable vascular tree like construction in 3D cell-dense tissues using artificial vascular bed. 2022/05
9.	Original article	Bioartificial pulsatile cuffs fabricated from human induced pluripotent stem cell-derived cardiomyocytes using a pre-vascularization technique 2022/03/31
10.	Original article	A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy 2022/03
11.	Other	A Short Commentary Based on our Article Entitled “Capillary Networks for Bio-Artificial Three-Dimensional Tissues Fabricated Using Cell Sheet Based Tissue Engineering” 2021/07/04
12.	Other	Reconstruction of a Vascular Bed with Perfusable Blood Vessels Using a Decellularized Porcine Small Intestine for Clinical Application 2021/03/19
13.	Original article	Continuous measurement of surface electrical potentials from transplanted cardiomyocyte tissue derived from human-induced pluripotent stem cells under physiological conditions in vivo. 2021/03
14.	Other	Bio-artificial pleura using allogenic cell sheet for closing of lung air leakage. 2020/12/01
15.	Review article	Capillary Networks for Bio-Artificial Three-Dimensional Tissues Fabricated Using Cell Sheet Based Tissue Engineering 2020/12
16.	Original article	A novel method to align cells in a cardiac tissue-like construct fabricated by cell sheet-based tissue engineering. 2020/06/01
17.	Original article	Intermittent application of external positive pressure helps to preserve organ viability during ex vivo perfusion and culture 2020/03
18.	Original article	Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model. 2020/02
19.	Original article	Engineering of functional cardiac tubes by stepwise transplantation of cardiac cell sheets onto intestinal mesentery. 2020/01/02
20.	Original article	Microfluidic vascular-bed devices for vascularized 3D tissue engineering: tissue engineering on a chip. 2019/12/20
21.	Original article	Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue 2019/12
22.	Original article	Sticker method for preparation of frozen section using adhesive film. 2019/12
23.	Original article	Mesenchymal stem cell sheets exert anti-stenotic effects in a rat arterial injury model. 2018/10
24.	Original article	Harvesting epithelial keratinocyte sheets from temperature-responsive dishes preserves basement membrane proteins and improves cell survival in a skin defect model. 2017/09
25.	Original article	Myoblast cell sheet transplantation enhances the endogenous regenerative abilities of infant hearts in rats with myocardial infarction 2017/06
26.	Original article	Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets. 2017/05
27.	Original article	Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue. 2017/03
28.	Original article	Three-dimensional functional human myocardial tissues fabricated from induced pluripotent stem cells. 2017/03
29.	Original article	Tubular Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells Generate Pulse Pressure In Vivo 2017/03
30.	Original article	In vivo vascularization of cell sheets provided better long-term tissue survival than injection of cell suspension. 2016/08
31.	Original article	Tracing behavior of endothelial cells promotes vascular network formation. 2016/05
32.	Original article	TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues. 2016/02
33.	Original article	Ex Vivo Prefabricated Rat Skin Flap Using Cell Sheets and an Arteriovenous Vascular Bundle 2015/07
34.	Review article	Development of Cardiac Tissues with the Ability for Independent Cardiac Assistance Using Cell Sheet Based Tissue Engineering 2015/05
35.	Original article	Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia 2014/04
36.	Original article	In vitro engineering of vascularized tissue surrogates 2013/02
37.	Original article	In Vitro Fabrication of Functional Three-Dimensional Tissues with Perfusable Blood Vessels 2013/01
38.	Review article	Cell sheets for regenerative medicine therapy and 3D tissue preparation 2012/12
39.	Review article	Myocardial tissue engineering: toward a bioartificial pump. 2012/03
40.	Original article	Cardiac cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection. 2011/12
41.	Original article	In vivo 3D analysis with micro-computed tomography of rat calvaria bone regeneration using periosteal cell sheets fabricated on temperature-responsive culture dishes 2011/06
42.	Review article	Tissue Engineering Using Laminar Cellular Assemblies 2009/04
43.	Review article	Cell sheet-based myocardial tissue engineering: new hope for damaged heart rescue 2009/01
44.	Original article	Functional closure of visceral pleural defects by autologous tissue engineered cell sheets. 2008/10
45.	Original article	Endothelial cell co-culture within tissue engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts. 2008/09
46.	Original article	Therapeutic angiogenesis using tissue engineered human smooth muscle cell sheets. 2008/04
47.	Other	Ambu-bag for the treatment of anesthesia-induced apnea in experimental rat 2008
48.	Review article	Reconstruction of functional tissues with cell sheet engineering. 2007/12
49.	Review article	Grand Espoir: Robotics in Regenerative Medicine 2007/10
50.	Review article	Cell sheet engineering for regenerative medicine: From the viewpoint of inflammation 2007/05
51.	Review article	Myocardial tissue reconstruction: The cell sheet engineering approach. 2007/05
52.	Original article	Cell delivery in regenerative medicine: the cell sheet engineering approach. 2006/11
53.	Original article	Pulsatile myocardial tubes fabricated with cell sheet engineering 2006/07
54.	Original article	Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. 2006/04
55.	Original article	Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. 2006/03
56.	Original article	Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets. 2006/03
57.	Review article	Cell sheet engineering: recreating tissues without biodegradable scaffolds. 2005/11
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■ Academic conference presentation

1.	Construction of a Three-Dimensional Tissue with a Dense Vascular Network by Culturing a Vascular Endothelial cells / Mesenchymal Stem cells co-cultured Cell Sheet under Intermittent Positive Pressure 2024/06/26
2.	Development of an artificial vascular bed using hydrogel to insert perfusable vascular network into 3D tissues. 2022/11/14
3.	SNRK regulates TGFβ levels in atria to prevent cardiac fibrosis. 2022/10/14
4.	Maturation and Improvement of Contractile and Relaxation Capacity of Human Induced Pluripotent Stem Cell Derived Engineered Cardiomyocyte Tissue 2019/11/27
5.	Improvement of Relaxation Function is a Novel Index of Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues 2019/11/17
6.	Advanced Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues in Terms of Contractile and Relaxation Capacity 2019/11/13
7.	In Vivo Vascularization for Tissue and Organ Fabrication 2019/10/16
8.	Development of Recellularized Acellular Porcine Intestine with Human Cells as a Human Implantable Vascular Bed 2019/10/14
9.	A novel cell alignment method of human induced pluripotent stem cell-derived cardiomyocytes by cell sheet extension 2018/09/07
10.	Strategy to fabricate human cardiac tubes in vitro for circulatory support 2018/09/07
11.	Engineering of vascularized transplantable cardiac tissues 2018/09/06
12.	External intermittent positive pressurized perfusion improves the organ viability on ex-vivo organ perfusion 2018/09/06
13.	Fabrication of a human implantable vascular bed using decellularized porcine small intestine re-endothelialized with human cells 2018/09/05
14.	Adipose Derived Mesenchymal Stromal Cell Sheet Transplantation Induces Functional Angiogenesis and Enhances Endogenous Neurogenesis in a Rat Stroke Model 2018/01/26
15.	Mesenchymal stem cell sheet from adventitia attenuates neointimal hyperplasia of injured artery 2018/01/06
16.	Fabrication of Human Transplantable Vascular Bed Utilizing Decellularized and Re-endothelialized Porcine Intestine 2017/09/23
17.	Development of novel bioreactor system with pulsatile-pressurization for tissue fabrication 2017/06/27
18.	Elimination of residual iPS cells in bioengineered cardiac cell sheets using Dinaciclib 2017/06/27
19.	Engineering of vascularized tubular myocardial tissues in vitro by using cell technology 2017/06/27
20.	Fabrication of a human transplantable vascular bed using re-endothelialized acellular porcine intestine 2017/06/27
21.	In vitro fabrication of 3D cardiac tissues with perfusable blood vessels by cell sheets engineering and measurement of the contractile force 2017/06/27
22.	ELIMINATION OF RESIDUAL IPS CELLS IN IPS-DERIVED CARDIAC TISSUE BY CDKS INHIBITION 2017/06/14
23.	Cell sheet-based Tissue Engineering for Treatment of Heart Failure 2017/06/09
24.	Analysis of metabolic activity using the engineered heart tissue model 2017/01/17
25.	Enhancing vascularization of layered cardiomyocyte sheets using VEGF releasing fiber mats 2016/12/15
26.	Enhanced Vascularization in Layered Cardiomyocyte Sheets using VEGF Releasing PVA Fiber Mat 2016/11/28
27.	Enhansment of blood vessel formation in prevascularized cell-dense tissue by growth factors administration 2016/11/28
28.	VEGF Releasing PVA Fiber Mat Enhances Vascularization in Layered Cardiomyocyte Sheets 2016/10/17
29.	Development of three-dimensional cardiac tissue construct using decellularized gastrointestine and cell sheet technology. 2016/09/05
30.	Development of novel bioreactor system with pulsatile pressurization for organ fabrication. 2016/09/04
31.	Construction of myocardial tissue with blood vessel structure with continuous release of VEGF 2016/07/27
32.	Ex vivo fabrication of heart tissue model with perfusable blood vessels using cell sheet 2016/07/20
33.	In vitro fabrication of human cardiac tissues with porcine perfusable blood vessels 2016/07/18
34.	Ex vivo engineering of vascularized heart tissue model 2016/07/01
35.	Elimination of residual iPS cells in bioengineered cardiac cell sheets by TRPV-1 activation 2016/06/23
36.	Vascularization into cardiomyocyte cell sheets in vivo using VEGF releasing particle loaded fiber mats 2016/03/25
37.	Development of cardiac tissues with the ability for independent cardiac assistance using cell sheet based tissue engineering 2015/11/27
38.	Myocardial Tube Fabrication Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Toward Bioengineered Heart Assist Pump In Vivo 2015/11/19
39.	Fabrication of vascularized 3-D heart tissue model for drug evaluation 2015/10/22
40.	Newly Developed Culture Method Providing Efficient Oxygen Supply to a Three-dimensional Artificial Tissue 2015/09/09
41.	The Model of Vascularized Three Dimensional Heart Tissue for Drug Evaluation 2015/09/09
42.	Cell Sheet Transplantation Ameliorates Cardiac Dysfunction of Infarcted Infant Hearts by Cardiomyocyte Proliferation and Angiogenesis 2015/09/08
43.	Evaluation of Cultured Epithelial Cell Sheets Basement Membrane using Temperature Responsive Dish without Enzymatic Treatment 2015/09/08
44.	Engineering of 3-D cardiac tissues with perfusable blood vessels in vitro 2014/09/26
45.	Successful transplantation of three-dimensional human myocardial tissues fabricated from induced pluripotent stem cell sheet technology 2014/05/20
46.	Evaluating the viability of in vitro engineered vascularized cardiac tissues and transplantation 2014/04/12
47.	Three-dimensional beating human myocardial tissues fabricated from induced pluripotent stem cells and cell sheet technology 2013/11/20
48.	Safety and Effectiveness of Innovative Tissue Therapy for Porcine Myocardial Infarction Using Autologous Skeletal myobkast sheets 2013/07/05
49.	In vivo fabrication of a vascular bed suitable for grafting cell sheets 2012/09/07
50.	Dynamics of engraftment of cardiac cell sheets in vivo and their angiogenic potential 2012/09/06
51.	Fabrication of a resectable microvascular bed suitable for grafting cell sheets 2012/03/17
52.	Ex vivo induction of microvascular network within the engineered 3D cardiac tissues using a novel bioreactor system 2011/11/12
53.	Induction of microvascular network within the engineered 3D cardiac tissues using a novel bioreactor system 2011/08/02
54.	Regeneration of Mesothelial Cell in the Damaged Peritoneum by Tissue Engineered Mesothelial Cell Sheet 2011/02/21
55.	Ex vivo induction of vascular network within the engineered 3D cardiac tissues 2011/01/17
56.	The creation of bronchial chondrocyte sheets for airway reconstruction. 2010/09/16
57.	Cell sheet transplantation improves Damaged heart function via more cell survival in comparison with dissociated cell injection 2009/11
58.	Cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection 2009/10
59.	Off-the-shelf cell sheets for closure of visceral pleural injuries 2009/09/01
60.	Cardiac cell sheet improves heart function via increase cell survival in comparison with dissociated cell injection 2009/08
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■ Research areas

Biomedical engineering, Biomedical engineering

■ Awards & honors

2010/09

Tissue Engineering & Regenerative Medicine International Society Asia pacific, Best Poster Award.

■ Academic society memberships

2006/04～

Tissue Engineering & Regenerative Medicine International Society

■ Education

1.	2008/08/06 Degree Acquisition	Jichi Medical University,
2.	2001/04～2003/03	Graduate School, Division of Health Care, International University of Health and Welfare, Completed,

■ Academic & professional experience

2022/11～

Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science Associate Professor

■ Rsearch funding number

60541737