Faculty Information - IWASAKI Naoko

Books

Published papers

Academic conference presentation

Main course titles

Qualifications & licenses

Research grants & projects

Conference activities & talks

Research areas

Academic society memberships

Academic & professional experience

External Researcher ID

（Last updated : 2025-04-23 17:34:49）

IWASAKI Naoko
Department School of Medicine(Yachiyo Medical Center), School of Medicine

Position Professor (Fixed Term)

■ Books

1.	Chapter contribution	MODY(maturity onset diabetes of the young)「Nihon Rinsyo」 2012/07
2.	Chapter contribution	Matiruty-onset diabetes of the young--a model for genetic studies of diabetes mellitus, Common Dosease: Genetic and pathogenic aspects of multifactorial diseases 1999
3.	Chapter contribution	Characteristics of non-insulin dependent diabetes in the young in Japan, Recent Trends in Management of Diabetes Mellitus 1987
4.	Chapter contribution	The effect of self monitoring of blood glucose in young insulin-dependent diabetic subjects, Recent Trends in Management of Diabetes Mellitus International Congress Series. 726 1987

■ Published papers

1.	Original article	Two novel pathogenic PDX1 variants in two Japanese patients with maturity-onset diabetes of the young 2025/04
2.	Original article	An adult female case with Fabry disease reffered to the genetic counseling who was happen to have Mulberry cells by routine health checkup. 2024/10/31
3.	Original article	High prevalence of copy number variations in the Japanese participants with suspected MODY 2024/04/29
4.	Original article	Outcomes of Presicion Medicine for Seven patients with MODY1 or MODY3 2023/10/07
5.	Original article	A novel pathogenic variant in the glucokinase gene found in two Japanese siblings with maturity-onset diabetes of the young 2 2023/04/13
6.	Original article	Low resting energy expenditure in postmenopausal Japanese women with type 2 diabetes mellitus 2019/10
7.	Review article	Role of vitamin D in mitochondrial function pancreatic b cell. 2018/11
8.	Original article	Diagnosis and Genetic Counseling for Mitochondrial Disease at the Institute of Medical Genetics, Tokyo Women's Medical University 2018/08
9.	Original article	Genetic Counseling for Couples Seeking Noninvasive Prenatal Testing in Japan: Experiences of Pregnant Women and their Partners 2017/06
10.	Case report	Pancreatic developmental defect evaluated by celiac artery angiography in a patient with MODY5 2016/07
11.	Review article	Career education at Tokyo Women's Medical University 2015/06
12.	Original article	Establishment of maturity-onset diabetes of the young-induced plripotent stem cells from a Japanese patient 2015/04
13.	Original article	Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes. 2015
14.	Original article	GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic beta cells 2014/04
15.	Case report	A sibling case of Wolfram syndrome with a novel mutation Y652X in WFS1. 2014
16.	Original article	Evaluation of add-on therapy of sitagliptin in Japanese patients with type 2 diabetes under insulin therapy 2014
17.	Original article	Localization of hepatocyte nuclear factor-4a in thenucleolus and nucleus is regulated by its C-terminus. 2012/10
18.	Original article	Whole gene deletion mutation of HNF1B and exonic aberration mutations of GCK and HNF1B in patients with MODY in Japan 2012/09
19.	Original article	Inhibition of glucose-stimulated insulinj secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes 2012/07
20.	Original article	A new mitochondrial pH biosensor for quantitative assessment of pancreatic β-cell function 2012/04
21.	Case report	A Case of Wolfram Syndrome Associated With Compound Heterozygous Mutation of WFS1: A Clinical Course of Unusual Longevity and Medical Management 2011/03
22.	Review article	Clinical feature and Diagnosis of Diabetes due to Mitochondria dysfunction 2011/02
23.	Original article	Genetic Polymorphisms in the Organic Cation Transporter 1, OCT1, in Chinese and Japanese Populations, Exhibit Altered Function 2010
24.	Original article	Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. 2010
25.	Case report	The over 50 year clinical course of a patient with slowly progressive type 1 diabetes (SPIDDM) 2010
26.	Original article	Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. 2009
27.	Original article	Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan 2008/08
28.	Original article	Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects 2008
29.	Original article	Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy 2008
30.	Original article	Multistage genome-wide SNP association study revealed KCNQ1 as a novel susceptibility gene for type 2 diabetes mellitus in multiple ethnic groups: a report of the Millennium Genome Project of Japan 2008
31.	Original article	Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population 2005
32.	Case report	mutations in the HNF－1αgene are not associated with glucose intolerance in offspring of diabetic mothers in Japan 2004/03/01
33.	Original article	Simultaneous estimation of haplotype frequencies and quantitative trait parameters: applications to the test of association between phenotype and diplotype configuration. 2004
34.	Original article	Transient elevation of liver transaninase after starting insulin therapy for diabetic ketosis or ketoacidosis in newly diagnosed type 1 diabetes mellitus. 2004
35.	Original article	Mapping genes influencing Type 2 diabetes Risk and body mass index in Japanese 2003
36.	Original article	Meta-analysis confirms a role for Calpain-10 variation in type 2 diabetes susceptibility. 2003
37.	Original article	Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells. 2002
38.	Original article	A novel splice site mutation in the Hepatocyte Nuclear Factor-1bgene, IVS2nt+1G>A, associated with maturity-onset diabetes young , agenesisi of left kidney and bicornuate uterus. 2001
39.	Original article	Beta-cell transcription factors and diabetes: No evidence for diabetes-associated mutations in the coding region of the Proendocrinr neurogenin 3 gene (NEUROG3)in Japanese patients with MODY 2001
40.	Original article	Identification of three missense mutations in peroxisome proliferator-activated receptor a in Japanese subjects with MODY but no association with diabetes 2001
41.	Original article	Mutation in the hepatocyte nuclear factor-1b(MODY5) gene are not a major factor contribution to end-stage -renal dosease in Japanese people with diabetes mellitus. 2001
42.	Original article	Prevalence of the A to G mutation at nucleotoide 3243 of the mitochondrial tRNA^(LeuUUR) gene in Japanese patients with diabetes mellitus and end stage renal disease. 2001
43.	Original article	The Pro112>Ala substitution in PPAR-gammma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. 2001
44.	Original article	β-Cell Transcription Factors and Diabetes No Evidence for Diabetes-Associated Mutations in the Hepatocyte Nuclear Factor- 3 Gene (HNF3B) in Japanese Patients With Maturity-Onset Diabetes of the Young 2000/02
45.	Original article	B-Cell Transcription factors and diabetes: No evidence for diabetes associated mutations in the gene encoding the basic -herix-loop^helix transcription factor Neurogenic differentiation 4(NEUROD) in Japanese patients with MODY 2000
46.	Original article	Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus 2000
47.	Original article	No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor- 4g(HNF4G) in Japanese patients with MODY 2000
48.	Original article	Polymyalgia rheumatica and type 2 diabetes mellitus complicated with electromyographic abnormalities thaht responded well to corticostroid therapy. 2000
49.	Original article	The Met416 to Val variant in the glycogen synthase gene 2000
50.	Original article	Polymorphism of the b3-adrenergic receptor gene and weight gain in pregnant diabetic women 1999
51.	Case report	Severe Protoracted Lichenoid eruption and hyperuricemia following administration of Alacepril 1999
52.	Original article	Structure/Function studies of Hepatocyte Nuclear Factor-1a, a Diabetes-Associated Factor 1999
53.	Original article	Liver and Kidney Function in Japanese Patients With Maturity-Onset Diabetes of the Young 1998/12
54.	Original article	β-Cell Transcription Factors and Diabetes Mutations in the Coding Region of the BETA2/NeuroDl (NEUR0D1) and Nkx2.2 (NKX2B) Genes Are Not Associated With Maturity-Onset Diabetes of the Young in Japanese 1998/08
55.	Original article	Mutations in the Coding Region of the Insulin Promoter Factor 1 Gene Are Not a Common Cause of Maturity-Onset Diabetes of the Young in Japanese Subjects 1998/05
56.	Original article	Immunoreactive Endothelin Levels in the Vitreous Fluid Are Decreased in Diabetic Patients with Proliferative Retinopathy 1998
57.	Original article	Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4a/MODYl Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY 1997/10
58.	Original article	Mutations in the Hepatocyte Nuclear Factor-la/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDM 1997/09
59.	Case report	A case of Type-1 diabetes mellitus formerly diagnosed as maturity-onset diabetes of the young (MODY) carrying suggestive MODY3 gene 1997
60.	Original article	Assessment of insulin resistance in acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy 1997
61.	Original article	Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with maturity-onset diabetes of the young 1997
62.	Original article	Absence of the Gly40-Ser mutation in the glucagon receptor gene in Japanese subjects with NIDDM 1996/07
63.	Original article	An Approach for Identifying Simple Sequence Repeat DNA Polymorphisms Near Cloned cDNAs and Genes Linkage Studies of the Islet Amyloid Polypeptide/Amylin and Liver Glycogen Synthase Genes and NIDDM 1996/03
64.	Original article	Identification of Microsatellite Markers Near the Human Genes Encoding the β-Cell ATP-Sensitive K+ Channel and Linkage Studies with NIDDM in Japanese 1996/03
65.	Original article	A genome-wide search for human non-insulin dependent (Type2) diabetes genes reveals a major susceptibility locus on chromosome 2 1996
66.	Original article	Mutations in the hepatocyte nuclear factor-1αgene in maturity-onset diabetes of the (MODY3) 1996
67.	Original article	Localization of MODY3 to a 5-cM Region of Human Chromosome 12 1995/12
68.	Original article	Insulin sensitivity in patients with NIDDM and the A-to-G mutation at nucleotide 3,243 of the Mitochondrial^tRNALeu(UUR) gene 1995/06
69.	Original article	Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA^Leu(UUR) genes 1995
70.	Original article	Successful xenograft transplantation to streptozotocin-induced diabetic rats without any immunosuppressants using a diffusion chamber as a bioartificial endocrine pancreas (Bio-AEP) 1995
71.	Original article	MODY in Japanese: clinical features and screening for mutations in the glucokinase and mitochomdrial tRNALeu(UUR) genes 1994
72.	Original article	Plasma endothelin levels in Diabetic patients with retinopathy 1993/02
73.	Original article	Reversal of glucose insensitivity of pancreatic B-cells due to prolonged exposure to high glucose in culture:Effect of Nicotinamide on pancreatic B-cells 1993
74.	Original article	Increased plasma endothelin in NIDDM patients with retinopathy 1992/10
75.	Original article	Dinucleotide repeat polymorphism in D20S17(CRI-L127) 1991
76.	Case report	One Japanese MODY family with severe and progressive microangiopathies 1988
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■ Academic conference presentation

1.	Current status of genetic counseling for MODY in our hospital （ポスター掲示，一般） 2024/10/11
2.	Continuous glucose monitoring in a patient with insulinoma before and after the operation （ポスター掲示，一般） 2024/06/22
3.	Systematic Genetic Analysis achieved 57.1% of detection rate in Japanese MODY patient. （ポスター掲示，一般） 2024/04/17
4.	Next Generation Sequencing in Japanese patients with Maturity-Onset Diabetes of the Young. （ポスター掲示，一般） 2023/10/12
5.	Current issues in the management of monogenic diabetes in our institution （口頭，シンポジウム・ワークショップパネル（指名）） 2023/07/22
6.	Genetic screening for monogenic diabetes using whole exome sequencing in a single hospital cohort in Japan （口頭，一般） 2022/09/22
7.	A case with Fabry disease who was diagnosed through routine health check-up by the detection of mulberry bodies in urinary sediment was led to the genetic counseling （口頭，一般） 2020/11/18
8.	Whole exome sequencing for clinically suspected MODY in Japanese （口頭，一般） 2020/11/18
9.	Clinical factors associated with asymptomatic coronary artery disease in patients with diabetes mellitus （ポスター掲示，一般） 2019/12/04
10.	Evaluation of Clinical Factors for Asymptomatic Coronary Lesions in Diabetic Patients （ポスター掲示，一般） 2019/12/04
11.	Progeroid syndrome with focal segmental glomeruloscrelosis due to ZMPSTE24 mutations （ポスター掲示，一般） 2019/06/16
12.	Screening for mutations in 14 kinds of MODY genes in patients with MODY in Japanese by next generation sequencing （ポスター掲示，一般） 2018/10/18
13.	Screening for mutations in 14 kinds of MODY genes in Patients with MODY in Japanese by Next generation sequencing （口頭，一般） 2018/10/13
14.	A novel mutation in the IPF-1/PDX-1 gene identified in a Japanese family with MODY. （ポスター掲示，一般） 2017/09/13
15.	Awareness of English medical interviews among 4th year students （ポスター掲示，一般） 2017/08/19
16.	Newly identified mutation in 5'UTR of HNF4A in a case of MODY3 （ポスター掲示，一般） 2017/05/20
17.	Effects of denosumab on fat and basal metabolism in postmenopausal women with type 2 diabetes （ポスター掲示，一般） 2016/09/19
18.	Prevalence of MODY subtype and clinical characteristics in patients with early onset diabetes in Japanese （口頭，一般） 2016/04/05
19.	Relationships of resting energy expenditure and bone metabolism in postmenopausal Japanese women with type 2 diabetes: 6-month follow-up with vitamin D supplementation （ポスター掲示，一般） 2015/10/11
20.	Consideration of teh factors affectingthe decision about wheather or not to have NIPT （ポスター掲示，一般） 2015/06/27
21.	Genetic variants in the lanosterol synthase gene are associated with type 2 diabetes （ポスター掲示，一般） 2015/06/08
22.	Relationship between energy expenditure and bone metabolism in post-menopausal women with Type 2 Diabetes （口頭，一般） 2014/07/25
23.	Changes and accelerating factors of the will to become doctors of the medical students （口頭，一般） 2014/07/19
24.	Detection of PAX4 mutation in Japanese patients with maturity-onset diabetes of the young （ポスター掲示，一般） 2013/09/27
25.	Phenotypic heterogeniety in Japanese patients with hepatocyte nuclear factor-1b mutations （ポスター掲示，一般） 2013/09/27
26.	Application of MODY probability calculator for Japanese patients with MODY3 （ポスター掲示，一般） 2013/06/22
27.	Efficacy of Concomitant in Japanese Type 2 Diabetes Mellitus Patient With Insulin and Sitagliptin, a DPP-4 inhibitor. （ポスター掲示，一般） 2013/06
28.	Effects of Glucagon like protein (GLP)-1 on mitochondrial function in cultured β cells （ポスター掲示，一般） 2013/04/24
29.	Identification of MODY-X gene in Japanese by combination of whole exome sequencing with linkage analysis （口頭，一般） 2012/11/27
30.	Liragultide Ameriorate the ethdium bromide induced mitochondrial dysfunction of cultured b-cell which are the model of MIDD （ポスター掲示，一般） 2012/11/26
31.	Liraglutide ameliorates the ethidium bromide induced mitochondrial dysfunction in cultured β cells （ポスター掲示，一般） 2012/11
32.	Whole exome sequencing identifiesCUL9 as a MODY-X gene （ポスター掲示，一般） 2012/10/02
33.	The development of the education on attitudes for the first-year students, 'Proper Behavior of the Medical Students' （ポスター掲示，一般） 2012/07/27
34.	Identification of KCNJ15 as a susceptibility gene in Asian patients with Type 2 diabetes Mellitus. （口頭，シンポジウム・ワークショップパネル（その他）） 2011/10/21
35.	Common variation in lanosterol synthase gene predispose to type 2 diabetes. （ポスター掲示，一般） 2011/09
36.	KATP channel and mitochondrial pH: Estimation of mitochondrial matrix pH in cultured living β cells using an improved ratiometric biosensor （ポスター掲示，一般） 2011/09
37.	Regulation of mitochondrial matrix pH by the activity and balance of complexes in the mitochondrial electron transport system in cultured living b cells: evaluation using a new modified system （ポスター掲示，一般） 2010/11/16
38.	Genetic counseling for MODY, MIDD and other type of diabetes mellitus. （ポスター掲示，一般） 2010/09/22
39.	Detection of genomic rearrangements of MODY gene in Japanese patients （ポスター掲示，シンポジウム・ワークショップパネル（その他）） 2010/02/08
40.	A novel susceptible gene to type 2 diabetes on chromosome 21 as a new target for the treatment （口頭，一般） 2009/04
41.	Detection of genomic rearrangements of MODY gene in Japanese （ポスター掲示，一般） 2009/04
42.	Deletion of the whole gene deletion mutation of the HNF-1b gene in Japanese Patients with MODY （ポスター掲示，一般） 2008/09/08
43.	Q268X, truncated mutant of HNF-4a causing MODY1, has nucleus-targeting ability and can bind with wild-type HNF-4a or its repressor SHP and accumulate them to the nucleus in cultured cells. （ポスター掲示，一般） 2008/09
44.	Achievement of learning objectives using portfolio in the Human Relations, humanity education curriculum （ポスター掲示，一般） 2008/07/26
45.	Association study based on the genome wide linkage results revealed two genes on chromosome 21 in type 2 diabetic subjects in Japanese. （ポスター掲示，一般） 2007/06/23
46.	Contribution of MafA Gene in the Pathogenesis of Clinical Diagnosis of MODY （ポスター掲示，一般） 2006/06
47.	Genetic variation in the VEGF gene is associated with Diabetic retinopathy in Japanese. （ポスター掲示，一般） 2005/06
48.	Genome Analysis and Medicine （ポスター掲示，シンポジウム・ワークショップパネル（指名）） 2004/12/06
49.	Linkage analysis of the MODY-X Pedigree in Japanese （ポスター掲示，一般） 2004/06
50.	Variation in the Calpain-10 Gene (CAPN10) is Associated with Type 2 Diabetes Risk and Insulin secretion in Japanese Subjects （ポスター掲示，一般） 2003/11
51.	Mapping genes influencing Type 2 diabetes Risk and body mass index in Japanese （ポスター掲示，一般） 2003/08
52.	Genome-wide search for type 2 diabetes in Japanese （ポスター掲示，一般） 2002/10
53.	Genome-wide search for type 2 diabetes in Japanese （ポスター掲示，一般） 2001/10
54.	Genome-wide search for type 2 diabetes in Japanese （ポスター掲示，一般） 2001/09
55.	Maturity-onset diabetes of the young (MODY) in Japanese （口頭，シンポジウム・ワークショップパネル（指名）） 2000/11/24
56.	Mutations in the HNF-1b and Mitochondrial tRNALeu(UUR) genes and kidney dysfunction in Japanese patients with diabetes （ポスター掲示，一般） 1999/06
57.	Clinical Characteristics of MODY in Japanese （ポスター掲示，一般） 1998/11/20
58.	Clinical characteristics of MODY in Japanese （口頭，シンポジウム・ワークショップパネル（指名）） 1998/11/03
59.	Clinical Characteristics of MODY in Japanese （ポスター掲示，一般） 1998/06/13
60.	Mutations in the hepatocyte nuclear factor-1a gene in japanese subjects with early- and late-onset NIDDM （ポスター掲示，一般） 1997/06/25
61.	A genome-wide screen for NIDDM-susceptibility genes in Japanese （ポスター掲示，一般） 1996/11/21
62.	A genome-wide screen for NIDDM-susceptibility genes in Japanese （ポスター掲示，一般） 1996/09/01
63.	Linkage between MODY and markers on chromosome 12 （ポスター掲示，一般） 1995/09/12
64.	Genome-wide search for Type 2 diabetes mellitus susceptibility genes in Japanese （口頭，一般） 1995/09
65.	Evaluation of Insulin Sensitivity in NIDDM Subjects with a Mitichondrial tRNALeu(UUR) Gene Mutation （ポスター掲示，一般） 1994/11
66.	Searching for diabetes-susceptibility genes in Japanese （ポスター掲示，一般） 1994/09
67.	MODY in Japanese: Clinical deatures and screening for mutations in the glucokinase and mitochondrial tRNA^Leu(UUR) genes. （ポスター掲示，シンポジウム・ワークショップパネル（その他）） 1993/10/26
68.	MODY in Japanese subjects: Clinical features and screening for mutations in the glucokinase gene （ポスター掲示，一般） 1993/06
69.	Genetic studies (Part 2)-Japan （ポスター掲示，一般） 1993/03
70.	Search for a marker for MODY in a Japanese family （ポスター掲示，一般） 1992/06
71.	Study of the clinica1 characteristics of MODY in Japan - Clinical profile of 12 families with MODY （ポスター掲示，一般） 1991/06
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■ Qualifications & licenses

2020/11/01

Fellow of American College of Physician (FACP)

■ Research grants & projects

2004/04

Mapping genes influencing Type 2 diabetes Risk and body mass index in Japanese (Key Word : )

■ Conference activities & talks

2015/06/09

Discovery of KCNJ15 and LSS variants for type 2 diabetes susceptibility started by a small sized sip pair analysis (Nashville, USA)

■ Research areas

Metabolism and endocrinology, Medical biochemistry, Science education, General internal medicine (Key Word：Diabetes, gene, SNP, MODY, genetic counseling)

■ Academic society memberships

1.		American Diabetes Association
2.		American Society of Human Genetics
3.		Asian Association for the Study of Diabetes
4.		European Association for the Study of Diabetes

■ Academic & professional experience

1.	2024/09～	Diabetes, Endocrinology and Metabolism
2.	2020/04～2023/03	Director in General
3.	2018/05～	Professor
4.	2007/08～2018/04	Associate Professor
5.	2005/04～	Associate Professor
6.	2004/08～	Associate Professor
7.	1998/06～2007	Lecturer
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■ External Researcher ID

orcID

0000-0002-1857-7890