Faculty Information - SHIMIZU Yuuko

Published papers

Academic conference presentation

Research areas

Academic society memberships

Education

Academic & professional experience

Rsearch funding number

（Last updated : 2026-04-30 17:44:27）

SHIMIZU Yuuko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Professor

■ Published papers

1.	Original article	Disability, Cognition, and Quality of Life in Individuals With Multiple Sclerosis: A 2-Year Cohort Study 2026/04/29
2.	Original article	A multicenter, retrospective study in patients with multiple sclerosis treated with natalizumab in a real-world setting in Japan: The REFIND study 2026/01/15
3.	Review article	Progress in the management of pregnancy in patients with neuromyelitis optica spectrum disorder 2025/10/27
4.	Original article	Impact of Symptoms of Neuromyelitis Optica Spectrum Disorder and Patient‐Determined Oral Glucocorticoid–Related Adverse Events on Patients' Daily Living and Emotions: A Qualitative Analysis From Japan 2025/09/19
5.	Original article	Satralizumab treatment in neuromyelitis optica spectrum disorder: effects on relapse, pain, and other medications used: a retrospective chart review 2025/08/24
6.	Case report	Hydrocephalus as an Initial Presentation of Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Disease: A Case Report and Review of Tumor-Mimicking Demyelination 2025/08/02
7.	Original article	Clinical practice guidelines for multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease 2023 in Japan 2024/08
8.	Case report	Clinical Experience with Dimethyl Fumarate and Natalizumab in Pregnant Women with Multiple Sclerosis: A Four-Patient Case Series 2024/07/16
9.	Original article	Efficacy and Safety of the Natural Killer T Cell-Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial 2024/01/15
10.	Original article	Disease activity and progression of disability in multiple sclerosis patients aged over 50 with or without disease-modifying drug treatment: a retrospective cohort study 2023/12/05
11.	Case report	Holmes tremor in progressive multifocal leukoencephalopathy: A video case report 2023/11/27
12.	Original article	Protocol Efficacy and Safety of NKT Cell-stimulatory Glycolipid OCH-NCNP1 for Patients with Relapsing Multiple Sclerosis: Protocol for a Randomized, Placebo-Controlled Clinical Trial 2023/11/23
13.	Original article	Immunotherapy for ocular myasthenia gravis: an observational study in Japan 2023/02
14.	Case report	IgG4-related brain pseudotumor mimicking CNS lymphoma. A case report. 2022/12
15.	Other	Monoclonal antibody treatment for multiple sclerosis and neuromyelitis optica spectrum disorder: An update 2022/08
16.	Case report	Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report 2022/07/03
17.	Original article	Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration 2022/03/07
18.	Original article	Correlation of the symbol digit modalities test with the quality of life and depression in Japanese patients with multiple sclerosis 2021/11
19.	Case report	Diagnostic utility of PCR from paraffin-embedded sinus specimens for rhinocerebral mucormycosis complicated by internal carotid artery thrombosis and cerebral infarction 2021/03
20.	Review article	Multiple sclerosis and neuromyelitis optica spectrum disorder 2021/02/01
21.	Original article	HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data 2021/01/12
22.	Original article	Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. 2020/04
23.	Case report	Association of IgG4-Related Arteritis With Recurrent Stroke. 2020/02
24.	Original article	Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis. 2020
25.	Case report	p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case. 2019/08
26.	Case report	PD-1 inhibitor-associated severe myasthenia gravis with necrotizing myopathy and myocarditis. 2019/04
27.	Original article	Cognition with magnetic resonance imaginh findings and social activities in patients with multiple sclerosis in Japanese cohot 2019/02
28.	Original article	Ischemic Stroke due to Virologically-Confirmed Varicella Zoster Virus Vasculopathy: A Case Series. 2019/02
29.	Review article	Japanese guidelines for dimethyl fumarate 2018/11
30.	Original article	Proton magnetic resonance spectroscopy differentiates tumefactive demyelinating lesions from gliomas. 2018/11
31.	Case report	Chronic sarcoid myopathy manifesting only as dysphagia and dysarthria in an 84-year-old woman. 2018/10
32.	Original article	CSF and clinical data are useful in differentiating CNS inflammatory demyelinating disease from CNS lymphoma. 2018/08
33.	Case report	Unilateral flapping tremor associated with internal carotid artery stenosis:-A subtype of limb shaking. 2018/05
34.	Original article	Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. 2018/03/22
35.	Original article	Validation of the brief international cognitive assessment for multiple sclerosis in Japan 2017/12
36.	Other	日本における多発性硬化症のための高額薬剤と医療経済学(High-priced drugs for multiple sclerosis and the medical economy in Japan) 2017/11
37.	Case report	Non-convulsive status epilepticus due to small subcortical hemorrhage mimicking hemispheric stroke 2017/05
38.	Review article	日常診療において、多発性硬化症への疾患修飾薬を、いつどのように変更すべきか?(When and how disease-modifying drugs for multiple sclerosis should be changed in daily practice) 2017/02
39.	Case report	Acquired hemophilia A associated with myasthenia gravis and Isaacs' syndrome 2016/10
40.	Original article	Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder. 2016/10
41.	Review article	Managemnt of myasthenia gravis in pregnancy 2016/05
42.	Case report	ヒトT細胞白血病ウイルス1型が関連する視神経脊髄炎スペクトラム疾患(Neuromyelitis optica spectrum disorders associated with human T-lymphotropic virus type 1) 2015/11
43.	Review article	[The patients with pregnancy of the neuroimmunological diseases: the management and treatment]. 2015/09
44.	Review article	The management for multiple sclerosis and neuromyelitis optica in pregnancy and childbearing 2015/02
45.	Original article	Outcome of pregnancy during interferon beta-1a therapy in Japanese patients with multiple sclerosis: interim results od postmarketing surveillance study 2015
46.	Review article	[How to manage medical treatment during pregnancy and childbirth]. 2014/11
47.	Original article	Gadolinium enhancement patterns of tumefactive demyelination lesions: correlations with brain biopsy findings and pathophysiology 2014/10
48.	Original article	Japanese cases of neuromyelitis optica spectrum disorder associated with myasthenia gravis and a review of the literature. 2014/10
49.	Case report	[Intracranial pyramidal lesions in subacute combined degeneration]. 2014/01
50.	Original article	Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis 2014/01
51.	Original article	Japanese guidelines for fingolimod in MS: putting into practice 2013/12
52.	Original article	Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. 2013/10
53.	Case report	Toxoplasmosis involving the rostral medulla oblongata bilaterally in a non-HIV patient. 2013/08
54.	Case report	Charcot-Marie-Tooth disease type 4C in Japan: report of a case. 2013/02
55.	Original article	Ulcerated carotid plaques with ultrasonic echolucency are causatively associated with thromboembolic cerebrovascular events. 2013/02
56.	Case report	Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion. 2012/12
57.	Review article	Neutralizing antibodies are associated with a reduction of interferon-β efficacy during the treatment of Japanese multiple sclerosis patients. 2012/10
58.	Original article	The MG-QOL15 Japanese version: validation and associations with clinical factors. 2012/08
59.	Case report	Sporadic late-onset nemaline myopathy in a patient with primary Sjögren's syndrome. 2012/02
60.	Original article	A case of adenoid cyctic carcinoma presenting as Garcin's syndrome without mass formation 2012/01
61.	Case report	Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion. 2012
62.	Original article	Long-term effects of cabergoline and levodopa in Japanese patients with early Parkinson's disease:A 5-year prospective study 2012
63.	Original article	Taste disorder in myasthenia graves: a multicenter cooerative study 2012
64.	Case report	Anti-signal recognition particle myopathy in the first decade of life. 2011/08
65.	Original article	Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patinets with multiple sclerosis and neuromyelitis optica 2011/08
66.	Original article	Topical naphazoline in the treatment of myasthenic blepharoptosis. 2011/07
67.	Original article	Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis. 2011/03
68.	Original article	Factors associated with depressive state in patients with myasthenia gravis: a multicentre cross-sectional study. 2011
69.	Original article	[Clinical features of NMO according to brain MRI findings]. 2010/09
70.	Original article	Renin-angiotensin system blockade safety reduces blood pressure in patients with minor ischemic stroke during the acute phase. 2010
71.	Case report	Highly selective leptomeningeal amyloidosis with transthyretin variant Ala25Thr 2009/04
72.	Original article	Correlation between magnetic resonance imaging findings and pathological observations in tumefactive multiple sclerosis 2009
73.	Case report	Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis. 2008/02
74.	Original article	多発性硬化症におけるインターフェロンβ-1b療法による末梢血細胞内サイトカインの変化(A long-term study of peripheral blood intracellular cytokines in Japanese multiple sclerosis patients treated with interferon beta-1b) 2007/12
75.	Case report	A case of biopsy-proven leptomeningeal amyloidosis and intravenous Ig-responsive polyneuropathy associated with the Ala25Thr transthyretin gene mutation. 2006/03
76.	Original article	Biochemical characteristics of variant transthretins causing hereditary leptomeningeal amyloidosis 2005/12
77.	Original article	Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. 2003/03
78.	Original article	Increase in peripheral blood leukocytes and chemokines during immunoadsorbent therapy 1997
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■ Academic conference presentation

1.	Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity and immunomudulatory treatment in patients with multiple sclerosis and neuromyelitis optica （Poster notice，General） 2010/04
2.	NMOSD/MOGAD therapies -mabs （Speech，Special/Invited Lecture） 2026/03/18
3.	Pregnancy Topics in NMOSD and MOGAD （Speech，Panelist at Symposium/Workshop (Appointed)） 2026/02/06
4.	A Qualitative Study on the Impact of Symptoms and Adverse Events of Oral Glucocorticoids on Daily Life in Patients with Neuromyelitis Optica Spectrum Disorder （Poster notice，General） 2025/10/06
5.	Brain pathological study in tumefactive MOG　antibody-associated disease: the role of B cells （Abstract Only，General） 2020/09
6.	Differences in peripheral blood lymphocytes subsets from patients with multiples sclerosis treated with fingolimod or dumethyl fumarate （Poster notice，General） 2019/09/11
7.	Ischemic Stroke Due to Varicella Zoster Virus Vasculopathy: Clinical, Laboratory, and Imaging Features （Poster notice，General） 2019/07/05
8.	Usefulness of proton magnetic resonance spectroscopy in differentiating tumefactive demyelinating lesions from gliomas （Poster notice，General） 2018/04/25
9.	Pregnancy outcome and change in lymphocyte subsets in peripheral blood in Japanese patients with multiple sclerosis after assisted reproductive technology （Poster notice，General） 2017/10/27
10.	Utility of CSF and clinical data in differentiating CNS inflammatory demyelinating disease from CNSlymphoma （Speech，General） 2017/09/21
11.	Multiple sclerpsos and neuromyelitis optica spectrum disorder after assisted reproductive technology （Poster notice，General） 2017/09/20
12.	Management of Asian MS and NMOSD patients during pregnancy and postpartum. （Speech，Special/Invited Lecture） 2016/10/28
13.	Plasma osteopontin levels and expression of cytokine receptors and regulatpry T cells in peripheral blood lymphocytes during pregnancy in neuromyelitis optica spectrum disorder and multiple sclerosis （Poster notice，General） 2016/09/15
14.	Assessment of the relationship between MR and C-11 Methionine PET findings in patients with tumefactive demyelinating lesions （Speech，General） 2016/02/18
15.	Risk of neuromyelitis optica spectrum disorder relpse associated with pregnancy on Japanese patients （Poster notice，General） 2014/09/11
16.	Th1/Th2-related chemokine receptors inperipheral T cells in patients with muliple sclerosis treated with fingolimod （Poster notice，Panelist at Symposium/Workshop (Appointed)） 2014/08/01
17.	Interferon-beta treatment in anti AQP4 antibody positive patients （Poster notice，General） 2009/10/02
18.	The clinical features of serum anti-aquaporin 4 antibody positive patients （Poster notice） 2009/04/29
19.	Gadolinium enhancement patterns of tumefactive demyelinating lesions: correlations with brain biopsy findings and pathophysiolosy （Speech，General） 2009/04
20.	Pathogenesis in a suspicious case of acute disseminated encephalo-myelitis (ADEM) presenting with charateristic MRI findings （Poster notice，General） 2008/09/19
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■ Research areas

Metabolism and endocrinology, Immunology

■ Academic society memberships

1.	2022/01～	∟ 倫理委員会委員
2.	2024/01	∟ 財務委員

■ Education

1.		Faculty of Medicine, Tokyo Women's Medical University, Graduated
2.	1994/03/18 Degree Acquisition	Tokyo Women's Medical University,

■ Academic & professional experience

2022/09～

Professor

■ Rsearch funding number

20246507