Faculty Information - Tsukahara Fujiko

Books

Published papers

Academic conference presentation

Education

Academic & professional experience

Rsearch funding number

（Last updated : 2024-01-20 12:49:17）

Tsukahara Fujiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Professor (Fixed Term)

■ Books

1.	Chapter contribution	Imatinib: Basic Results, Chemotherapy for Leukemia Novel Drugs and Treatment 2017/04
2.	Chapter contribution	Induction of cationic amino acid transporter-2 mRNA by tumor necrosis factor-α is associated with nitric oxide production in human umbilical vein endothelial cells, The Biology of Nitric Oxide Part 6 1998
3.	Chapter contribution	Effect of tumor necrosis factor on the lipoprotein lipase gene expression in brown adipocytes differentiated in culture. Thermal Balance in Health and Disease, Advances in Pharmacological Sciences 1st ed 1994

■ Published papers

1.	Review article	Discovery of BCR-ABL chimeric gene, development of TKI for CML treatment, and overcoming drug resistance 2023/08/15
2.	Review article	Secondary Publication: COVID-19 Pandemic: Drug Development and Treatment 2021/07/05
3.	Review article	COVID-19 Pandemic　　Drug Development and Drug Treatment 2021/02
4.	Review article	Inflammatory Disease (6) Inflammation and Cancer 2020/12
5.	Original article	Lung Tumor Cell Recruitment Assay. 2019/02
6.	Review article	Malignant Tumor (4) Molecular Targeted Drugs 2018/12/25
7.	Original article	Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. 2018/08/03
8.	Original article	C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines. 2018/08
9.	Original article	Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. 2018/01
10.	Original article	Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example. 2015
11.	Original article	Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. 2014
12.	Original article	Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70. 2013
13.	Original article	p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. 2011/09
14.	Original article	Bag1 directly routes immature BCR-ABL for proteasomal degradation. 2010/11
15.	Original article	Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs. 2008/04
16.	Original article	Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus lifecycle 2006
17.	Original article	N-acetyl-cysteine enhances growth in BCR-ABL-transformed cells 2005
18.	Original article	Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kB and AP-1 2004
19.	Original article	Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70 2004
20.	Original article	Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90 2004
21.	Original article	Suppression by 12b-estradiol of monosyte adhesion to vascular endothelial cells is mediated by estrogen receptors 2004
22.	Original article	A novel G-protein-coupled receptor gene expressed in striatum 2000
23.	Original article	Anti-NO action of carvedilol in cell-free system and in vascular endothelial cells 2000
24.	Original article	Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70 2000
25.	Original article	Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein 1999
26.	Original article	Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome 1998
27.	Original article	The effect of acute cold exposure and norepinephrine on uncoupling protein gene expression in brown adipose tissue of monosodium glutamate-obese mice 1998
28.	Original article	A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus 1997
29.	Original article	Augmentation of tumor necrosis factor-alpha-induced suppression of lipoprotein lipase by nitric oxide donors in cultured brown adipocytes 1997
30.	Original article	Cationic amino acid transporter-2 mRNA induction by tumor necrosis factor-α in vascular endothelial cells 1997
31.	Original article	Defective stimulation of thyroxine 5'-deiodinase activity by cold exposure and norepinephrine in brown adipose tissue of monosodium glutamate-obese mice 1997
32.	Original article	Iodothyronine deiodinases in a mammalian hibernator, the chipmunk (Tamias asiaticus) 1997
33.	Original article	Nitric oxide mediates down regulation of lipoprotein lipase activity induced by tumor necrosis factor-α in brown adipocytes 1997
34.	Original article	Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2 1996
35.	Original article	Tolerance to lipopolysaccharide-induced increase in vascular permeability in mouse skin 1996
36.	Original article	Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture 1995
37.	Original article	Possible involvement of L-arginine-nitric oxide pathway in modulating regional blood flow to brown adipose tissue of rats 1994
38.	Original article	Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin 1994
39.	Original article	The effect of acute reserpine administration on the unconpling protein mRNA levels in the mouse brown adipose tissue 1994
40.	Original article	Impairment of cold-induced increase in thyroxine 5'-deiodinase activity in mouse brown adipose tissue by the intracerebroventricular administration of bombesin 1992
41.	Original article	α1-Adrenergic stimulation of iodide organification in mouse thyroid: Inhibition by protein kinase C inhibitors 1991
42.	Original article	Serum concentrations of thyroid hormones and activity of iodothyronine deiodinase in peripheral tissues of the house musk shrew, Suncus murinus 1990
43.	Original article	Effect of reserpine pretreatment on brown fat iodothyronine 5'-deiodinase of mouse 1989
44.	Original article	Properties of 5'-deiodinase of 3,3',5'-triiodothyronine in rat skeletal muscle 1989
45.	Original article	In vitro study on thyroid hormone metabolism of human placenta in early pregnancy 1986
46.	Original article	Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats 1982
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■ Academic conference presentation

1.	Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia 2018/09/25
2.	Mechanism of ALS-related mutant SOD protein degradation in microglia 2017/04/27
3.	Prolyl isomerase Pin1 promotes degradation of chronic myeloid leukemia oncoprotein, BCR-ABL 2017/03/17
4.	TLR4 signaling induces imatinib-resistance in Chronic myeloid leukemia-model cells 2014/09
5.	Inhibition of immature protein sensor Bag1-mediated BCR-ABL degradation by Hsp90-cdc37chaperone 2012/03/16
6.	Bag1 targets conformationally immature BCR-ABL for degradation 2011/05
7.	Bag1 regulates chaperone-mediated triage decisions on degradation of chronic myelogenous leukemia oncoprotein. 2010/07
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■ Education

1.		Faculty of Pharmaceutical Science, Tokyo University of Science, Graduated,
2.	Degree Acquisition	Tokyo Women's Medical University,

■ Academic & professional experience

1.	2006/04～2019/05	Tokyo Women's Medical University Department of Pharmacology Lecturer
2.	1978/04～2006/03	Tokyo Women's Medical University Department of Pharmacology Research Assistant

■ Rsearch funding number

40119996