Faculty Information - ICHIHARA Atsuhiro

（Last updated : 2025-04-28 21:44:37）

ICHIHARA Atsuhiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Professor and Division head

■ Books

1.	Chapter contribution	Antihypertensive agents and CAVI, Cardio-Ankle Vscular Index - Overview & Clinical Application - 2021/10/24
2.	Chapter contribution	Renal diseases and CAVI, Cardio-Ankle Vscular Index - Overview & Clinical Application - 2021/10/24

■ Published papers

1.	Case report	Subacute thyroiditis during anti-programmed cell death protein 1 antibody therapy: A case report 2025/05
2.	Other	Identification of causal candidates for pregnancy-induced hypertension through Bayesian model averaging-based Mendelian randomization. 2024/08
3.	Original article	Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia 2024/08
4.	Original article	Prediction of endogenous mineralocorticoid receptor activity by depressor effects of mineralocorticoid receptor antagonists in patients with primary aldosteronism. 2024/06
5.	Original article	Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study. 2024/06
6.	Other	Effects of esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, independent of urinary sodium/potassium ratio and salt intake. 2024/04
7.	Other	Lowering of blood pressure by chemical ablation of the unilateral adrenal gland in spontaneously hypertensive rats. 2024/02
8.	Original article	Comparisons of risk factors for post-treatment renal dysfunction between the two major subtypes of primary aldosteronism 2023/12/12
9.	Original article	Characteristics of month-by-month blood pressure variability in patients on hemodialysis. 2023/11
10.	Original article	Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics 2023/09/11
11.	Original article	Impact of Abdominal Fat Distribution on Mortality and Its Changes Over Time in Patients Undergoing Hemodialysis: A Prospective Cohort Study. 2023/07
12.	Original article	Soluble (pro)renin receptor level in patients with severe obesity is associated with visceral adiposity and is involved with insulin resistance and renal injury. 2023/05
13.	Other	Late age at menopause positively associated with obesity-mediated hypertension. 2023/02
14.	Original article	Hyperuricemia and the Severity of Coronavirus Disease 2019 in Japan: A Retrospective Cohort Study - An Inseparable Relation with Hypertension and Chronic Kidney Disease 2023
15.	Review article	Assessment of cardiovascular disease risk by plasma renin activity changes in patients with primary aldosteronism on mineralocorticoid receptor antagonist treatment. 2022/09
16.	Case report	Pituicytoma with pleomorphism: A case report with cytological findings 2022/08/30
17.	Original article	Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors 2022
18.	Original article	Comparison of the usefulness of the cardio-ankle vascular index and augmentation index as an index of arteriosclerosis in patients with essential hypertension. 2021/12
19.	Original article	Effects of mineralocorticoid receptor antagonists on sex hormones and body composition in patients with primary aldosteronism. 2021/12
20.	Other	Efficacy of esaxerenone-a nonsteroidal mineralocorticoid receptor blocker-on nocturnal hypertension. 2021/11
21.	Original article	Serum soluble (pro)renin receptor level as a prognostic factor in patients undergoing maintenance hemodialysis. 2021/08
22.	Original article	Immunohistochemistry for (pro)renin receptor in humans 2021/07/28
23.	Original article	Clinical impacts of endothelium-dependent flow-mediated vasodilation assessment on primary aldosteronism. 2021/06
24.	Original article	Effect of Pretransplant Use of Calcimimetic on Parathyroid Function after Renal Transplantation. 2021
25.	Original article	Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans. 2021
26.	Original article	Characteristics of NAFLD Based on Hypopituitarism. 2020/10
27.	Case report	Autopsy of malignant paraganglioma causing compressive myelopathy due to vertebral metastases. 2020/09/03
28.	Original article	Comparison of Shortened with Standard Saline Infusion Test for Primary Aldosteronism Diagnostics 2020/05/08
29.	Review article	Management of primary aldosteronism and mineralocorticoid receptor-associated hypertension. 2020/05
30.	Original article	Cosyntropin stimulation in adrenal vein sampling improves the judgment of successful adrenal vein catheterization and outcome prediction for primary aldosteronism 2020/04/30
31.	Original article	Safety and feasibility of unilateral double femoral venous access including double sheath insertion via a single-hole method for adrenal venous sampling 2020/04/13
32.	Original article	Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts. 2020/04
33.	Original article	Adrenal cortex hypoxia modulates aldosterone production in heart failure. 2020/03
34.	Original article	Clinical factors affecting spot urine fractionated metanephrines in patients suspected pheochromocytoma/paraganglioma. 2020/02
35.	Original article	Association between serum soluble (pro)renin receptor level and worsening of cardiac function in hemodialysis patients: A prospective observational study. 2020
36.	Case report	Primary aldosteronism in Klinefelter’s syndrome: two cases 2019/12
37.	Original article	Serum-soluble (pro)renin receptor concentration as a biomarker for organ damage in primary aldosteronism. 2019/12
38.	Review article	The (pro)renin receptor in health and disease. 2019/11
39.	Other	JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration. 2019/10
40.	Original article	Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor. 2019/09
41.	Original article	(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis. 2019/07
42.	Original article	Characteristics of visit-to-visit blood pressure variability in hemodialysis patients. 2019/07
43.	Other	JSH Statement: Kyoto declaration on hypertension research in Asia. 2019/06
44.	Case report	ACTH-Dependent Cyclic Cushing Syndrome Triggered by Glucocorticoid Excess Through a Positive-Feedback Mechanism. 2019/05
45.	Other	The Japanese Society of Hypertension-Digest of plan for the future. 2018/12
46.	Original article	Fatal Fournier's gangrene caused by Clostridium ramosum in a patient with central diabetes insipidus and insulin-dependent diabetes mellitus: a case report. 2018/08
47.	Original article	Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level. 2018/06
48.	Original article	Complete remission of hypertension in a hemodialysis patient after adrenalectomy for primary aldosteronism and renal transplantation. 2018/05
49.	Original article	The rationale and design of reduction of uncontrolled hypertension by Remote Monitoring and Telemedicine (REMOTE) study. 2018/04
50.	Original article	Buffering roles of (pro)renin receptor in starvation-induced autophagy of skeletal muscles. 2018/03
51.	Original article	Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan. 2018/03
52.	Original article	Elevated (Pro)renin Receptor Expression Contributes to Maintaining Aerobic Metabolism in Growth Hormone Deficiency 2018/03
53.	Other	Image Fusion Guidance with Pre-procedural CT with Real-Time Fluoroscopy for Adrenal Venous Sampling. 2018/03
54.	Original article	Hypertensive disorders of pregnancy: a strong risk factor for subsequent hypertension 5 years after delivery. 2018/02
55.	Original article	Serum Soluble(Pro)Renin Receptor Level is Increased in Association with Impaired Renal Function in Patients with Autosomal Dominant Polycystic Kedney Disease 2018/02
56.	Case report	Hormone-replacement Therapy for Hepatopulmonary Syndrome and NASH Associated with Hypopituitarism. 2018
57.	Original article	Prediction of response to medical therapy by serum soluble (pro)renin receptor levels in Graves' disease. 2018
58.	Original article	Body mass index and contralateral ratio predict outcome following unilateral adrenalectomy in primary aldosteronism. 2017/12
59.	Original article	Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice. 2017/12
60.	Original article	Urinary Sodium-to-Potassium Ratio Tracks the Changes in Salt Intake during an Experimental Feeding Study Using Standardized Low-Salt and High-Salt Meals among Healthy Japanese Volunteers. 2017/08
61.	Original article	Disruption of the vacuolar-type H(+)-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. 2017/04
62.	Original article	Effects of L- and N-Type Ca Channel Blocker Cilnidipine on Changes in Heart Rate and QT Interval During Dialysis. 2017
63.	Other	Overlap of post-obstructive siuresis and unmasled diabetes insipidus in case of IgG4-related retroperioneal fibrosis and tuberoinfundibular hypophysitis:A case report and review of the literature. 2017
64.	Original article	The relationships between the differences in central blood pressure and brachial blood pressure and other factors in patients with essential hypertension 2017
65.	Original article	The Relationships between the Differences in the Central Blood Pressure and Brachial Blood Pressure and Other Factors in Patients with Essential Hypertension. 2017
66.	Original article	Corrigendum to "Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia" [YPLAC 37C (2016) 72-78]. 2016/11
67.	Original article	Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4. 2016/10
68.	Original article	Serum soluble (pro)renin receptor levels in maintenance hemodialysis patients 2016/07
69.	Original article	Successful Adrenal Venous Sampling by Non-experts with Reference to CT Images. 2016/07
70.	Original article	Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport. 2016/04
71.	Review article	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016/01
72.	Original article	Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia. 2016/01
73.	Original article	Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia 2016
74.	Original article	Dual adrenal venous phase contrast-enhanced MDCT for visualization of right adrenal veins in patients with primary aldosteronism. 2015/10
75.	Original article	Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney 2015/08
76.	Original article	Nephron-specific deletion of the prorenin receptor causes a urine concentration defect. 2015/07
77.	Original article	Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade. 2015/05
78.	Original article	Vacuolar ATPase in phagosome-lysosome fusion. 2015/05
79.	Case report	Osteomalacia, severe thoracic deformities and respiratory failure in a young woman with anorexia nervosa. 2015/04
80.	Original article	(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma. 2015/03
81.	Original article	A functional (pro)renin receptor is expressed in human lymphocytes and monocytes. 2015/03
82.	Original article	The relationships between visit-to-visit blood pressure variability and renal and endothelial function in chronic kidney disease 2015/03
83.	Original article	The relationships between visit-to visit blood pressure variability and renal and endothelial function in chronic kidney disease 2015
84.	Original article	Effects of cilnidipine on sympathetic nerve activity and cardiorenal function in hypertensive patients with type 2 diabetes mellitus: association with BNP and aldosterone levels. 2014/12
85.	Review article	Possible contribution of (pro)renin receptor to development of gestational diabetes mellitus. 2014/12
86.	Original article	Roles of the (pro)renin receptor in the kidney 2014/11
87.	Original article	Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells. 2014/05
88.	Original article	Visceral fat level is an independent risk factor for cardiovascular mortality in hemodialysis patients. 2014/05
89.	Case report	Dissociative disorder due to Graves' hyperthyroidism: a case report 2014/04
90.	Original article	Visceral Fat Level Is an Independent Risk Factor for Cardiovascular Mortality in Hemodialysis Patients 2014/03
91.	Original article	Clinical features and therapeutic outcomes of acromegaly during the recent 10 years in a single institution in Japan. 2014/02
92.	Original article	Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. 2014/02
93.	Original article	(Pro)renin receptor blocker improves survival of rats with sepsis. 2014/01
94.	Review article	Novel approach to cardiovascular diseases: a promising probability of (pro)renin receptor [(P)RR]. 2014
95.	Review article	Serum soluble (pro)renin receptor levels in patients with essential hypertension. 2014
96.	Original article	Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. 2013/12
97.	Original article	Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease. 2013/12
98.	Original article	Angiotensin-converting enzyme inhibitor does not suppress renal angiotensin II levels in angiotensin I-infused rats. 2013/06
99.	Original article	Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. 2013/06
100.	Original article	Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester. 2013/06
101.	Original article	Primary examination 2013/06
102.	Original article	Combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine in patients with malignant pheochromocytoma and paraganglioma. 2013/04
103.	Original article	Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study. 2013/03
104.	Original article	The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis. 2013/02
105.	Original article	Novel sandwich ELISA for detecting the human soluble (pro)renin receptor. 2013/01
106.	Original article	Role of (pro)renin receptor in Ang II-mediated EGF receptor transactivation. 2013/01
107.	Original article	Effects of Adding Ezetimibe to Fluvastatin on Kidney Function in Patients with Hypercholesterolemia: a Randomized Control Trial. 2013
108.	Original article	Acid-activated prorenin binds to (pro)renin receptor in vitro. 2012/11
109.	Original article	Effects of Adding Ezetimibe to Fluvastatin on Kidney Function in Patients with Hypercholesterolemia: a Randomized Control Trial. 2012/11
110.	Original article	Soluble (pro)renin receptor and blood pressure during pregnancy: a prospective cohort study. 2012/11
111.	Review article	(Pro)renin Receptor and Vacuolar H⁺-ATPase 2012/09
112.	Review article	[Regulatory mechanisms for the renin-angiotensin-aldosterone system]. 2012/09
113.	Review article	[The cutting-edge of medicine; (Pro) renin receptor and renal disease]. 2012/08
114.	Original article	Enhanced intrarenal receptor-mediated prorenin activation in chronic progressive anti-thymocyte serum nephritis rats on high salt intake. 2012/07
115.	Review article	Guidelines for the use and interpretation of assays for monitoring autophagy. 2012/04
116.	Review article	Response to Metoki. 2012/03
117.	Original article	Risk factors for cardiovascular events in Japanese patients treated with fluvastatin from the long-term event monitoring (LEM) study. 2012/03
118.	Review article	(Pro)renin receptor and autophagy in podocytes. 2012/02
119.	Review article	Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase. 2011/12
120.	Original article	Prorenin receptor is essential for normal podocyte structure and function. 2011/12
121.	Original article	Prediction of pregnancy-induced hypertension by a shift of blood pressure class according to the JSH 2009 guidelines. 2011/11
122.	Review article	Functional characterization of (pro)renin receptor in association with V-ATPase. 2011/06
123.	Review article	Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance. 2011/06
124.	Original article	Qualitative and quantitative analyses of (pro)renin receptor in the medium of cultured human umbilical vein endothelial cells. 2011/06
125.	Original article	Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway. 2011/04
126.	Original article	Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). 2011
127.	Original article	Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome. 2010/08
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■ Academic conference presentation

1.	Hypertension in middle-aged and menopausal women （Speech，Panelist at Symposium/Workshop (Appointed)） 2024/10/14
2.	A case of clinical adult-onset nesidioblastosis with repeated severe hypoglycemia treated by two times pancreatectomies （Speech，General） 2024/06/28
3.	Weekly Somapacitan Reduces Serum C-reactive Protein Levels in Adult Patients with Growth Hormone Deficiency （Poster notice，General） 2024/06/03
4.	Growth hormone secretion and serum high-sensitivity C-reactive protein levels in adult patients with non-functioning pituitary tumors （Poster notice，General） 2023/06/17
5.	A negative association between growth hormone secretion and inflammation in adult patients with non-functioning pituitary mass （Poster notice，General） 2023/05/15
6.	Renoprotective Effect of Aliskiren Monotherapy in Hypertensive Patients with Obesity and Type 2 Diabetes Mellitus （Poster notice，General） 2022/10/15
7.	Association between cardiac (pro)renin receptor expression and myocardial hypertrophy in human （Poster notice，General） 2021/04
8.	Serum soluble (pro)renin receptor concentrations associated with progression of heart failure in hemodialysis patients （Poster notice，General） 2021/04
9.	Increased Serum High-sensitivity C-reactive Protein in Growth Hormone-deficient Patients with Non-functioning Pituitary Tumors （Poster notice，General） 2021/03/20
10.	Serum Soluble (Pro)renin Receptor Level as a Prognostic Factor in Patients Undergoing Maintenance Hemodialysis （Poster notice，General） 2021/03
11.	High-sensitivity C-reactive protein and growth hormone deficiency in patients with non-functioning pituitary tumors （Speech，General） 2021/02/19
12.	Effects of Body Mass Index and Estimated Glomerular Filtration Rate on Pituitary Function in Patients with Non-functioning Pituitary Tumor （Poster notice，General） 2019/05/19
13.	Contribution of soluble (pro)renin receptor to the maintenance of oxidative metabolism in hypoxic trophoblasts （Speech） 2019/05
14.	Effects of Obesity and Renal Function on Pituitary Function Tests in Patients with Nonfunctioning Pituitary Tumor （Poster notice，General） 2019/03/23
15.	Possible roles of (pro)renin receptor induced by hypoxia in trophoblasts （Speech） 2018/10
16.	Primary Aldosteronism in Klinefelter's Syndrome: Two Cases Report （Poster notice，General） 2018/09/22
17.	Primary Hyperparathyroidism in a Patient with Primary Aldosteronism （Poster notice，General） 2018/09/22
18.	Renoprotective Effect of Direct Renin Inhibitor Monotherapy in Hypertensive Patients with Type 2 Diabetes or Obesity （Speech，General） 2018/09/14
19.	Serum soluble (pro)renin receptor concentration is correlated with organ dysfunctions in patients with primary aldosteronism （Poster notice，General） 2018/09
20.	(Pro)renin Receptor Contributes to Maintaining Aerobic Metabolism in GH-deficient Adipose Tissue （Poster notice，General） 2018/03/18
21.	An old patient with acromegaly treated with consideration of past history and preventing frailty （Speech，General） 2018/02/09
22.	Renal prognosis of diabetic patients with and without central diabetes insipidus （Poster notice） 2017/05
23.	(Pro)renin receptor immunohistochemistry in human organs 2016/09
24.	A novel biomarker urinary soluble (pro)renin receptor excretion is associated with urineph 2016/09
25.	Evaluation of Insulin Sensitivity and Secretion in Primary Aldosteronism. (Pro)renin receptor immunohistochemistry in human organs. 2016/09
26.	The renin-angiotensin system and the sympathetic nervous system in the regulation of blood pressure by the brain and kidneys （Speech） 2016/09
27.	Urinary Na/K ratio monitoring and social networking-based information sharing are useful in achieving dietary NaCl reductuion 2016/09
28.	(Pro)renin receptor and non-communicable diseases in hypertensives （Speech，Special/Invited Lecture） 2015/12
29.	Relationships between serum soluble (pro)renin receptor levels and endocrine or metabolic factors in patients with essential hypertension. 2015/09
30.	Serum soluble (pro)renin receptor levels in patients undergoing hemodialysis 2015/09
31.	A case of hemodialysis patient with primary aldosteronism which was difficult to differentiate from pheochromocytoma 2015/05
32.	Associations between renal function and indices of renin-angiotensin system in patients with essential hypertension 2014/05
33.	Clinical implications of the difference in central blood pressure and brachial blood pressure in patients with essential hypertension 2014/04
34.	CVD therapy for unresectable pheochromocytoma （Poster notice，General） 2013/08
35.	Periodic ectopic Cushing's syndrome potentially evoked by glucocorticoid excess （Poster notice，General） 2013/06/16
36.	Glucose and lipid metabolic disorders as complications of acromegaly and their reversibility after transsphenoidal surgery. （Poster notice，General） 2013/06
37.	High-dose Cabergoline Treatment of Childhood- and Adolescence-onset Prolactinomas. （Speech，General） 2013/06
38.	The diagnosis and treatment of primary aldosteronism associated with end-stage renal disease （Poster notice，General） 2013/06
39.	Changes of eGFR after transsphenoidal surgery in patients with acromegaly （Speech，General） 2013/03/16
40.	Clinical features of Hypophysitis （Poster notice，General） 2012/10/18
41.	A prospective study of two-year high dose cabergoline therapy for acromegalic patients with post-operative residual tumor （Poster notice，General） 2012/06
42.	DOES NATIONWIDE GH ASSAY STANDARDIZATION AFFECT POST-SURGICAL REMISSION CRITERIA FOR ACROMEGALY IN JAPAN? （Poster notice，General） 2012/06
43.	The findings on Magnetic Resonance Imaging and Clinical Characteristics in 14 Patients with Hypophysitis （Speech，General） 2012/02/25
44.	(Pro)renin receptor and diabetes （Speech，Special/Invited Lecture） 2011/12
45.	The (pro)Renin receptor:Where Are We Now? （Speech） 2011/11
46.	(Pro)renin Receptor is Essential for Expression of Slit Diaphragm Proteins in Murine Podocytes. （Speech，General） 2011/09
47.	Involvement of Pro(renin) and Its Receptor Associated Novel Renin Angiotensin System in Pathogenesis of Preeclampsia. （Speech，General） 2011/09
48.	Physiological Roles Of (pro)renin receptor/atp6ap2 In Vascular Smooth Muscle Cells. （Speech，General） 2011/09
49.	The Reduction Of Prorenin Levels By Diet And Exercise Therapies Using Telemedicine Ameliorates Insulin Resistance In Patients With Metabolic Syndrome. （Speech，General） 2011/09
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