Faculty Information - YAMAMOTO Tomoko

（Last updated : 2025-09-29 10:47:38）

YAMAMOTO Tomoko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Associate Professor

■ Books

1.	Chapter contribution	Multiple Functions of Fukutin, the Gene Responsible for Fukuyama Congenital Muscular Dystrophy, Especially in the Central Nervous System, Advances in Muscular Dystrophy Research - From Cellular and Molecular Basis to Therapies [Working Title] 2022/10/17
2.	Chapter contribution	Ocular Pathology of Fukuyama Congenital Muscular Dystrophy, Muscular Dystrophies 2018/12
3.	Chapter contribution	Molecular Targeting of Brain Tumors, Frontiers in CNS Drug Discovery 2017/03
4.	Chapter contribution	Possible diverse roles of fukutin: more than basement membrane formation?, Muschular dystrophy 2012/05

■ Published papers

1.	Original article	Suppressive role of fukutin on cell proliferation in uterine cervical carcinoma in relation to Aurora-A kinase 2025/09
2.	Case report	A Case of Mesothelial-Cell Inclusions in the Mediastinal Lymph Nodes After Lung Cancer Surgery 2025/07
3.	Case report	Myositis associated with antimitochondrial autoantibodies presenting with early respiratory failure 2025/05/27
4.	Review article	Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis 2025/03/10
5.	Case report	A case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis 2025/02
6.	Case report	An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient 2024/11
7.	Case report	Osimertinib-induced BRAF mutation in a single metastatic lesion among multiple pulmonary lesions in a case of lung cancer with EGFR exon 19 deletion 2024/06
8.	Case report	A case of pulmonary primary MALT lymphoma with distinctive bronchoscopic findings 2024/05
9.	Original article	Metabolic and epigenetic reprogramming in a case of nuclear protein in testis (NUT) carcinoma of the retroperitoneum. 2024/01/23
10.	Case report	Pneumococcal infectious aortic aneurysm: A caution for a life-threatening vascular complication caused by non-vaccine-covered serotypes 2023/08/17
11.	Case report	Appendiceal cancer showing a submucosal tumor-like morphology in the ascending colon on colonoscopy: a case report 2023/08
12.	Case report	Adenocarcinoma with mediastinal lymph node involvement developed from a pure ground grass nodule during 14 years 2023/04/14
13.	Case report	Pituicytoma with pleomorphism: A case report with cytological findings 2022/08/30
14.	Case report	Differential diagnoses of calcified nodules in pulmonary amyloidosis: A case report 2022/08/29
15.	Case report	Lung Cancer Detected by Chest Computed Tomography in a Fever Outpatient Department for COVID-19 2022/08/25
16.	Case report	Ovarian serous carcinoma in which mediastinal recurrence of the cancer was resected 16 years after surgery: A case report 2022/05/23
17.	Case report	A case of tertiary hyperparathyroidism due to hypophosphatemic rickets 2022/02/25
18.	Original article	Fukutin regulates tau phoshorylation and synaptic function : Novel properties of fukutin in neurons 2022/01/13
19.	Original article	Fukutin Protein Participates in Cell Proliferation by Enhancing Cyclin D1 Expression through Binding to the Transcription Factor Activator Protein-1: An in vitro Study 2021/11/10
20.	Case report	Notably small bronchial carcinoid accompanied by peripheral aquamous cell carcinoma 2021/09/12
21.	Case report	Pedunculated early colorectal cancer with nodal metastasis: a case report. 2021/09
22.	Case report	Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report 2021/07
23.	Original article	Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT 2021/06/23
24.	Case report	A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan. 2021/01/15
25.	Case report	A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan 2021/01/02
26.	Case report	Breast metastasis from medullary thyroid carcinoma: a report of a case 2021
27.	Original article	Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral.sclerosis 2020/10/29
28.	Case report	Autopsy of malignant paraganglioma causing compressive myelopathy due to vertebral metastases. 2020/09/03
29.	Case report	Two primary cancers: Primary squamous cell carcinoma with extensive ichthyosis uteri and cervical endometrioid carcinoma: A case report. 2020/08/13
30.	Case report	Parathyroid carcinoma in a 13-year-old girl with a long-term survival 2020/06/22
31.	Case report	Mediastinal paraganglioma successfully resected by robot-assisted thoracoscopic surgery with en bloc chest wall resection: a case report 2020/03
32.	Case report	Recurrent pericardial effusion with pericardial amyloid deposition: a case report and literature review. 2019/12/06
33.	Case report	Primary aldosteronism in Klinefelter’s syndrome: two cases 2019/12
34.	Original article	Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis 2019/11/20
35.	Case report	A Case of Unexplained Pleural Effusion Diagnosed as Meigs’ Syndrome 2019/09/24
36.	Case report	p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case. 2019/08
37.	Case report	Submandibular Gland Hemangioma 2019/07
38.	Case report	Trans-subxiphoid robot-assisted thoracoscopic surgery for resecting multiple thymomas: a case report 2019/06/21
39.	Case report	Two primary cancers: Primary squamous cell carcinoma with extensive ichthyosis uteri and cervical endometrioid carcinoma: A case report 2019
40.	Original article	Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung 2018/07
41.	Original article	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration. 2018/06
42.	Original article	Complete remission of hypertension in a hemodialysis patient after adrenalectomy for primary aldosteronism and renal transplantation. 2018/05
43.	Case report	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case 2018/02
44.	Case report	TWO CASES OF MALIGNANT ADENOMYOEPITHELIOMA OF THE BREAST 2018/02
45.	Case report	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration 2017/12
46.	Case report	Atypical teratoid / rhabdoid tumor metastasizing to lumbar spinal cord -A case report with cerebrospinal fluid cytological findings- 2017/11
47.	Review article	Pathological Diagnosis of Renal Cell Carcinoma - Current Status and Future Perspectives 2017/09
48.	Original article	Predictive value of myenteric and submucosal plexitis for postoperative Crohn's disease recurrence 2017/04
49.	Case report	Synchronous and Bilateral Oncocytic Carcinoma of the Breast: A case report and review of the literature. 2017/03
50.	Case report	Well-differentiated adenocarcinoma associated with ulcerative colitis 2017/01
51.	Original article	Laparoscopically Removed Streak Gonad Revealed Gonadoblastoma in Frasier Syndrome 2017
52.	Case report	Breast carcinoma with neuroendocrine featuers. Cytological findings of four cases. 2016/12
53.	Case report	Palatal Osseous Choristoma. 2016/01
54.	Case report	Fat-poor angiomyolipoma with cyst-like changes mimicking a cystic renal cell carcinoma: a case report. 2015/08
55.	Review article	Gonadal Tumor in Frasier Syndrome: A Review and Classification 2015/04
56.	Case report	Cartilaginous choristoma of the tongue 2015/03
57.	Original article	High prevalence of the MYD88 mutation in testicular lymphoma:immunohistochemical and genetic analyses 2015
58.	Review article	The Muscular Dystrophies Associated with Central Nervous System Lesions: A Brief Review from a Standpoint of the Localization and Function of Causative Genes 2014/10
59.	Original article	MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS 2013/06
60.	Original article	Fine needle aspiration versus core needle biopsy in the diagnosis of the intraductal breast papillary lesions 2013
61.	Original article	Post-transcriptional regulation of fukutin in an astrocytoma cell line 2012/03
62.	Original article	Roles of Fukutin, the Gene Responsible for Fukuyama-Type Congenital Muscular Dystrophy, in Neurons: Possible Involvement in Synaptic Function and Neuronal Migration 2011/04
63.	Original article	4-hydroxy-2-nonenal upregurates and phosporylates cytosolic phospholipase A₂ in cultured Ra2 microglial cells via MAPK pathways 2011
64.	Original article	A useful immunohistochemical approach to evaluate intraductal proliferative lesions of the breast to predict their prognosis. 2011
65.	Case report	Intravascular Large B-Cell Lymphoma of the Uterus: A Case Showing Favorable Clinical Outcome 2011
66.	Original article	Activation of STAT3 and inhibitory effect of pioglitazone on STAT3 activity in a mouse model of SOD-1-mutated amyotrophic lateral sclerosis. 2010
67.	Review article	Functions of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in neuromuscular system and other somatic organs. 2010
68.	Original article	Involvement of 4-hydroxy-2-nonenal accumulation in multiple system atrophy. 2010
69.	Original article	Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: histopathological, immunohistochemical and semiquantitative investigations 2010
70.	Original article	Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and lkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis 2008/08
71.	Original article	Characteristics of neurons and glia in the brain of Fukuyama type congenital musculae dystrophy 2008/07
72.	Original article	A role of fukutin,a gene responsible for Fukuyama type congenital muscular dystrophy,cancer cells:a possible role to suppress csll proliferation 2008
73.	Original article	Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutationassociated familial amyotrophic lateral sclerosis and its transgenic mouse model 2007/02
74.	Case report	A case showing transition from T-cell-rich polymorphic lesion to diffuse large B-cell lymphoma. 2007
75.	Original article	Intracellular binding of fukutin and alpha-dystoglycan:relation to glycosylation of alpha-dystroglycan 2006/12
76.	Original article	Crotonaldehyde accumulates in glial cells of Alzheimer's disease brain 2006/05
77.	Review article	Expression and localizaton of fukutin,POMGnT1,and POMT1 in the central nervous system:consideration for function of fukutin 2004/12
78.	Original article	Fukutin expression in mouse non-muscle somatic organs: its relationship to the hypoglycosylation of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. 2004/10
79.	Original article	Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis 2004/09
80.	Original article	Expression of genes related to muscular dystrophy with lissencephaly 2004/09
81.	Original article	Co-localization of fukutin and α-dystroglycan in the mouse central nervous system 2004/06
82.	Original article	Lytic infection of Epstein-Barr virus(EBV)in hemophagocytic syndrome associated with EBV-induced lymphoproliferative disorder 2004/02
83.	Original article	Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation 2002/08
84.	Original article	Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients 2001/10
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■ Academic conference presentation

1.	Novel properties of fukutin in cultured astrocytes （Speech，General） 2022/06/25
2.	Epigenetic regulation of TERT through metabolic reprogramming contributes to aggressive phenotypes of pituitary tumors （Speech，General） 2021/05/27
3.	An autopsy case of ADPKD with multiorgan failure induced by infection of hepatic syst （Poster notice，General） 2021/04/24
4.	Transduction of cyclin D1 by osteopontin in papilllary thyroid carcinoma cell line TPC-1 （Poster notice，General） 2021/04/24
5.	Clinicopathological study on renal cell carcinoma with tubulocystic architectures. （Poster notice，General） 2019/09/27
6.	Renal cell carcinoma with tubulocystic architectures - Clinicopathological study on 5 cases （Poster notice，General） 2019/05/11
7.	Malignant solitary fibrous tumor in the kindney. A case report （Poster notice，General） 2019/05/10
8.	Mixed epithelial and stromal tumor (MEST) in the kidney of the male patient. A case report （Poster notice，General） 2019/05/10
9.	Overian mature teratoma with nephroblastoma component showing dissemination:a case report （Poster notice，General） 2019/05/10
10.	Proliferation of cultured astrocytes carrying ALS-related mutant SOD1 （Poster notice，General） 2019/05/10
11.	Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia （Poster notice，General） 2018/09/25
12.	Expression and localization of xCT and CD44v6 in papillary thyroid carcinoma （Poster notice，General） 2018/06/21
13.	A case of MALT lymphoma of the thymus （Poster notice，General） 2017/09/02
14.	FH-deficient RCC with a Tubulocystic RCC-like morphology.A case report （Poster notice，General） 2017/04/27
15.	Mechanism of ALS-related mutant SOD protein degradation in microglia （Poster notice，General） 2017/04/27
16.	Intraoperative cytology for ovarian tumor （Speech，General） 2016/05/30
17.	Relationship between ceruloplasmin and glutamate in amyotrophic lateral sclerosis （Poster notice，General） 2016/05/20
18.	Implications for lysophosphatidylcholine in amyotrophic lateral sclerosis （Poster notice，General） 2015/05/21
19.	Glutamate stimulates motor neurons to form intracellular p-TDP-43 aggregates （Speech，General） 2014/12/05
20.	Implications for lysophosphatidylcholine in periinfarct microglial activation （Poster notice，General） 2014/09/15
21.	A Case of Plasmablastic Lymphoma Initially Noticed as a Testicular Tumor （Poster notice，General） 2013/09/07
22.	A case of malignant mesothelioma in cervical area: a rare manifestation of mesotherlioma suspected by aspiration cytology. （Poster notice，General） 2010/11/06
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