Faculty Information - YAMAMOTO Tomoko

（Last updated : 2026-02-19 15:20:00）

YAMAMOTO Tomoko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Associate Professor

■ Books

1.	Chapter contribution	Multiple Functions of Fukutin, the Gene Responsible for Fukuyama Congenital Muscular Dystrophy, Especially in the Central Nervous System, Advances in Muscular Dystrophy Research - From Cellular and Molecular Basis to Therapies [Working Title] 2022/10/17
2.	Chapter contribution	Ocular Pathology of Fukuyama Congenital Muscular Dystrophy, Muscular Dystrophies 2018/12
3.	Chapter contribution	Molecular Targeting of Brain Tumors, Frontiers in CNS Drug Discovery 2017/03
4.	Chapter contribution	Possible diverse roles of fukutin: more than basement membrane formation?, Muschular dystrophy 2012/05

■ Published papers

1.	Original article	Discordance of intrinsic subtype between primary tumor and lymph node metastasis in breast cancer patients 2026
2.	Original article	Fascin expression is associated with aggressive clinicopathological features in parathyroid tumors 2026
3.	Case report	Cardiac involvement in a patient with Aortic Aneurysm, Familial Thoracic-8. 2025/11/26
4.	Original article	Suppressive role of fukutin on cell proliferation in uterine cervical carcinoma in relation to Aurora-A kinase 2025/09
5.	Case report	A Case of Mesothelial-Cell Inclusions in the Mediastinal Lymph Nodes After Lung Cancer Surgery 2025/07
6.	Case report	Myositis associated with antimitochondrial autoantibodies presenting with early respiratory failure 2025/05/27
7.	Review article	Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis 2025/03/10
8.	Case report	A case of gastric/duodenal diffuse large B cell lymphoma observed during the administration of tacrolimus/azathioprine for dermatomyositis 2025/02
9.	Case report	An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient 2024/11
10.	Case report	Osimertinib-induced BRAF mutation in a single metastatic lesion among multiple pulmonary lesions in a case of lung cancer with EGFR exon 19 deletion 2024/06
11.	Case report	A case of pulmonary primary MALT lymphoma with distinctive bronchoscopic findings 2024/05
12.	Original article	Metabolic and epigenetic reprogramming in a case of nuclear protein in testis (NUT) carcinoma of the retroperitoneum. 2024/01/23
13.	Case report	Pneumococcal infectious aortic aneurysm: A caution for a life-threatening vascular complication caused by non-vaccine-covered serotypes 2023/08/17
14.	Case report	Appendiceal cancer showing a submucosal tumor-like morphology in the ascending colon on colonoscopy: a case report 2023/08
15.	Case report	Adenocarcinoma with mediastinal lymph node involvement developed from a pure ground grass nodule during 14 years 2023/04/14
16.	Case report	Pituicytoma with pleomorphism: A case report with cytological findings 2022/08/30
17.	Case report	Differential diagnoses of calcified nodules in pulmonary amyloidosis: A case report 2022/08/29
18.	Case report	Lung Cancer Detected by Chest Computed Tomography in a Fever Outpatient Department for COVID-19 2022/08/25
19.	Case report	Ovarian serous carcinoma in which mediastinal recurrence of the cancer was resected 16 years after surgery: A case report 2022/05/23
20.	Case report	A case of tertiary hyperparathyroidism due to hypophosphatemic rickets 2022/02/25
21.	Original article	Fukutin regulates tau phoshorylation and synaptic function : Novel properties of fukutin in neurons 2022/01/13
22.	Original article	Fukutin Protein Participates in Cell Proliferation by Enhancing Cyclin D1 Expression through Binding to the Transcription Factor Activator Protein-1: An in vitro Study 2021/11/10
23.	Case report	Notably small bronchial carcinoid accompanied by peripheral aquamous cell carcinoma 2021/09/12
24.	Case report	Pedunculated early colorectal cancer with nodal metastasis: a case report. 2021/09
25.	Case report	Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report 2021/07
26.	Original article	Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT 2021/06/23
27.	Case report	A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan. 2021/01/15
28.	Case report	A case of pulmonary tumor embolism diagnosed with respiratory distress immediately after FDG-PET/CT scan 2021/01/02
29.	Case report	Breast metastasis from medullary thyroid carcinoma: a report of a case 2021
30.	Original article	Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral.sclerosis 2020/10/29
31.	Case report	Autopsy of malignant paraganglioma causing compressive myelopathy due to vertebral metastases. 2020/09/03
32.	Case report	Two primary cancers: Primary squamous cell carcinoma with extensive ichthyosis uteri and cervical endometrioid carcinoma: A case report. 2020/08/13
33.	Case report	Parathyroid carcinoma in a 13-year-old girl with a long-term survival 2020/06/22
34.	Case report	Mediastinal paraganglioma successfully resected by robot-assisted thoracoscopic surgery with en bloc chest wall resection: a case report 2020/03
35.	Case report	Recurrent pericardial effusion with pericardial amyloid deposition: a case report and literature review. 2019/12/06
36.	Case report	Primary aldosteronism in Klinefelter’s syndrome: two cases 2019/12
37.	Original article	Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis 2019/11/20
38.	Case report	A Case of Unexplained Pleural Effusion Diagnosed as Meigs’ Syndrome 2019/09/24
39.	Case report	p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case. 2019/08
40.	Case report	Submandibular Gland Hemangioma 2019/07
41.	Case report	Trans-subxiphoid robot-assisted thoracoscopic surgery for resecting multiple thymomas: a case report 2019/06/21
42.	Case report	Two primary cancers: Primary squamous cell carcinoma with extensive ichthyosis uteri and cervical endometrioid carcinoma: A case report 2019
43.	Original article	Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung 2018/07
44.	Original article	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration. 2018/06
45.	Original article	Complete remission of hypertension in a hemodialysis patient after adrenalectomy for primary aldosteronism and renal transplantation. 2018/05
46.	Case report	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case 2018/02
47.	Case report	TWO CASES OF MALIGNANT ADENOMYOEPITHELIOMA OF THE BREAST 2018/02
48.	Case report	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration 2017/12
49.	Case report	Atypical teratoid / rhabdoid tumor metastasizing to lumbar spinal cord -A case report with cerebrospinal fluid cytological findings- 2017/11
50.	Review article	Pathological Diagnosis of Renal Cell Carcinoma - Current Status and Future Perspectives 2017/09
51.	Original article	Predictive value of myenteric and submucosal plexitis for postoperative Crohn's disease recurrence 2017/04
52.	Case report	Synchronous and Bilateral Oncocytic Carcinoma of the Breast: A case report and review of the literature. 2017/03
53.	Case report	Well-differentiated adenocarcinoma associated with ulcerative colitis 2017/01
54.	Original article	Laparoscopically Removed Streak Gonad Revealed Gonadoblastoma in Frasier Syndrome 2017
55.	Case report	Breast carcinoma with neuroendocrine featuers. Cytological findings of four cases. 2016/12
56.	Case report	Palatal Osseous Choristoma. 2016/01
57.	Case report	Fat-poor angiomyolipoma with cyst-like changes mimicking a cystic renal cell carcinoma: a case report. 2015/08
58.	Review article	Gonadal Tumor in Frasier Syndrome: A Review and Classification 2015/04
59.	Case report	Cartilaginous choristoma of the tongue 2015/03
60.	Original article	High prevalence of the MYD88 mutation in testicular lymphoma:immunohistochemical and genetic analyses 2015
61.	Review article	The Muscular Dystrophies Associated with Central Nervous System Lesions: A Brief Review from a Standpoint of the Localization and Function of Causative Genes 2014/10
62.	Original article	MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS 2013/06
63.	Original article	Fine needle aspiration versus core needle biopsy in the diagnosis of the intraductal breast papillary lesions 2013
64.	Original article	Post-transcriptional regulation of fukutin in an astrocytoma cell line 2012/03
65.	Original article	Roles of Fukutin, the Gene Responsible for Fukuyama-Type Congenital Muscular Dystrophy, in Neurons: Possible Involvement in Synaptic Function and Neuronal Migration 2011/04
66.	Original article	4-hydroxy-2-nonenal upregurates and phosporylates cytosolic phospholipase A₂ in cultured Ra2 microglial cells via MAPK pathways 2011
67.	Original article	A useful immunohistochemical approach to evaluate intraductal proliferative lesions of the breast to predict their prognosis. 2011
68.	Case report	Intravascular Large B-Cell Lymphoma of the Uterus: A Case Showing Favorable Clinical Outcome 2011
69.	Original article	Activation of STAT3 and inhibitory effect of pioglitazone on STAT3 activity in a mouse model of SOD-1-mutated amyotrophic lateral sclerosis. 2010
70.	Review article	Functions of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in neuromuscular system and other somatic organs. 2010
71.	Original article	Involvement of 4-hydroxy-2-nonenal accumulation in multiple system atrophy. 2010
72.	Original article	Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: histopathological, immunohistochemical and semiquantitative investigations 2010
73.	Original article	Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and lkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis 2008/08
74.	Original article	Characteristics of neurons and glia in the brain of Fukuyama type congenital musculae dystrophy 2008/07
75.	Original article	A role of fukutin,a gene responsible for Fukuyama type congenital muscular dystrophy,cancer cells:a possible role to suppress csll proliferation 2008
76.	Original article	Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutationassociated familial amyotrophic lateral sclerosis and its transgenic mouse model 2007/02
77.	Case report	A case showing transition from T-cell-rich polymorphic lesion to diffuse large B-cell lymphoma. 2007
78.	Original article	Intracellular binding of fukutin and alpha-dystoglycan:relation to glycosylation of alpha-dystroglycan 2006/12
79.	Original article	Crotonaldehyde accumulates in glial cells of Alzheimer's disease brain 2006/05
80.	Review article	Expression and localizaton of fukutin,POMGnT1,and POMT1 in the central nervous system:consideration for function of fukutin 2004/12
81.	Original article	Fukutin expression in mouse non-muscle somatic organs: its relationship to the hypoglycosylation of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. 2004/10
82.	Original article	Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis 2004/09
83.	Original article	Expression of genes related to muscular dystrophy with lissencephaly 2004/09
84.	Original article	Co-localization of fukutin and α-dystroglycan in the mouse central nervous system 2004/06
85.	Original article	Lytic infection of Epstein-Barr virus(EBV)in hemophagocytic syndrome associated with EBV-induced lymphoproliferative disorder 2004/02
86.	Original article	Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation 2002/08
87.	Original article	Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients 2001/10
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■ Academic conference presentation

1.	Novel properties of fukutin in cultured astrocytes （Speech，General） 2022/06/25
2.	Epigenetic regulation of TERT through metabolic reprogramming contributes to aggressive phenotypes of pituitary tumors （Speech，General） 2021/05/27
3.	An autopsy case of ADPKD with multiorgan failure induced by infection of hepatic syst （Poster notice，General） 2021/04/24
4.	Transduction of cyclin D1 by osteopontin in papilllary thyroid carcinoma cell line TPC-1 （Poster notice，General） 2021/04/24
5.	Clinicopathological study on renal cell carcinoma with tubulocystic architectures. （Poster notice，General） 2019/09/27
6.	Renal cell carcinoma with tubulocystic architectures - Clinicopathological study on 5 cases （Poster notice，General） 2019/05/11
7.	Malignant solitary fibrous tumor in the kindney. A case report （Poster notice，General） 2019/05/10
8.	Mixed epithelial and stromal tumor (MEST) in the kidney of the male patient. A case report （Poster notice，General） 2019/05/10
9.	Overian mature teratoma with nephroblastoma component showing dissemination:a case report （Poster notice，General） 2019/05/10
10.	Proliferation of cultured astrocytes carrying ALS-related mutant SOD1 （Poster notice，General） 2019/05/10
11.	Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia （Poster notice，General） 2018/09/25
12.	Expression and localization of xCT and CD44v6 in papillary thyroid carcinoma （Poster notice，General） 2018/06/21
13.	A case of MALT lymphoma of the thymus （Poster notice，General） 2017/09/02
14.	FH-deficient RCC with a Tubulocystic RCC-like morphology.A case report （Poster notice，General） 2017/04/27
15.	Mechanism of ALS-related mutant SOD protein degradation in microglia （Poster notice，General） 2017/04/27
16.	Intraoperative cytology for ovarian tumor （Speech，General） 2016/05/30
17.	Relationship between ceruloplasmin and glutamate in amyotrophic lateral sclerosis （Poster notice，General） 2016/05/20
18.	Implications for lysophosphatidylcholine in amyotrophic lateral sclerosis （Poster notice，General） 2015/05/21
19.	Glutamate stimulates motor neurons to form intracellular p-TDP-43 aggregates （Speech，General） 2014/12/05
20.	Implications for lysophosphatidylcholine in periinfarct microglial activation （Poster notice，General） 2014/09/15
21.	A Case of Plasmablastic Lymphoma Initially Noticed as a Testicular Tumor （Poster notice，General） 2013/09/07
22.	A case of malignant mesothelioma in cervical area: a rare manifestation of mesotherlioma suspected by aspiration cytology. （Poster notice，General） 2010/11/06
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