Faculty Information - Ono Masafumi

Published papers

Academic conference presentation

Research areas

Academic society memberships

Education

Academic & professional experience

（Last updated : 2023-02-18 16:31:14）

Ono Masafumi
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine

Position

■ Published papers

1.	Original article	Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis. 2020/03
2.	Original article	Antidiabetic Treatments for Diabetes with Liver Cirrhosis 2020/03
3.	Original article	Hepatoprotective effect of SGLT2 inhibitor on nonalcoholic fatty liver diseases 2020/03
4.	Original article	Estimated Prevalence of Advanced Hepatic Fibrosis by Elastography in Patients with Type 2 Diabetes 2020/02
5.	Original article	Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis. 2019/09
6.	Original article	Infection phase is a predictor of pruritus in patients with hepatitis B virus infection. 2019/08
7.	Original article	Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non-alcoholic fatty liver disease. 2019/03
8.	Original article	New microwave ablation system for unresectable liver tumors that forms large, spherical ablation zones. 2018/12
9.	Original article	Correction to: The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study. 2018/11
10.	Original article	The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study. 2018/11
11.	Original article	Wisteria floribunda agglutinin-positive Mac-2-binding protein and type 4 collagen 7S: useful markers for the diagnosis of significant fibrosis in patients with non-alcoholic fatty liver disease. 2018/10
12.	Original article	Lack of 17β-estradiol reduces sensitivity to insulin in the liver and muscle of male mice. 2018/09
13.	Original article	A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD. 2018/07
14.	Original article	Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring. 2018/07
15.	Original article	New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease. 2018/05
16.	Original article	Are donors or recipients a more important predictive factor for the development of non-alcoholic fatty liver disease after liver transplantation? 2018/02
17.	Original article	Prevalence of pruritus in patients with chronic liver disease: A multicenter study. 2018/02
18.	Original article	Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis. 2017/10
19.	Original article	High fasting insulin concentrations may be a pivotal predictor for the severity of hepatic fibrosis beyond the glycemic status in non-alcoholic fatty liver disease patients before development of diabetes mellitus. 2017/09
20.	Original article	Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS. 2017/08
21.	Original article	Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. 2017/08
22.	Original article	Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice. 2017/05
23.	Original article	Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease. 2017
24.	Original article	Suppression of MicroRNA-7 (miR-7) Biogenesis by Nuclear Factor 90-Nuclear Factor 45 Complex (NF90-NF45) Controls Cell Proliferation in Hepatocellular Carcinoma. 2016/09
25.	Original article	Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. 2016/06
26.	Original article	Characterization of Ovarian Responses to Equine Chorionic Gonadotropin of Aromatase-Deficient Mice With or Without 17β-Estradiol Supplementation. 2016/05
27.	Original article	Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice. 2016/05
28.	Other	Are genetic variations the most important risk factors for development of hepatocellular carcinoma? 2016/04
29.	Original article	Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography. 2016/03
30.	Original article	A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers. 2015/11
31.	Original article	Biphasic effect of alcohol intake on the development of fatty liver disease. 2015/11
32.	Original article	Co-administration of insulin with a gonadotropin partly improves ovulatory responses of estrogen-deficient mice. 2015/08
33.	Original article	Is non-alcoholic fatty liver disease a systemic disease that promotes extrahepatic cancer development? 2015/07
34.	Original article	Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers. 2015/07
35.	Original article	Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. 2015/04
36.	Original article	Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. 2015/04
37.	Original article	MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis. 2015/04
38.	Original article	Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). 2015/03
39.	Original article	Insulin resistance correlated with the severity of liver histology in Japanese NAFLD patients: a multicenter retrospective study. 2015/02
40.	Original article	Clinical usage of serum ferritin to assess liver fibrosis in patients with non-alcoholic fatty liver disease: Proceed with caution. 2014/12
41.	Original article	Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients. 2014/11
42.	Original article	Upper limit of normal serum alanine aminotransferase levels in Japanese subjects. 2014/11
43.	Original article	Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. 2014/08
44.	Original article	Uric acid levels decrease with fibrosis progression in patients with nonalcoholic fatty liver disease. 2014/08
45.	Original article	The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease. 2014/07
46.	Original article	Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice. 2014/06
47.	Original article	Aromatase-null mice expressing enhanced green fluorescent protein in germ cells provide a model system to assess estrogen-dependent ovulatory responses. 2014/04
48.	Original article	LDL-migration index (LDL-MI), an indicator of small dense low-density lipoprotein (sdLDL), is higher in non-alcoholic steatohepatitis than in non-alcoholic fatty liver: a multicenter cross-sectional study. 2014
49.	Original article	Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels. 2013/09
50.	Original article	Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease. 2013
51.	Original article	Hepatocyte destruction with enhanced collagen synthesis: characteristic feature of chronic hepatitis C patients on haemodialysis. 2013
52.	Other	Third-generation inhibitor for the renin–angiotensin system: Can it strongly protect against progression of hepatic fibrosis in non-alcoholic steatohepatitis? 2013
53.	Original article	Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients. 2012/11
54.	Original article	17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice. 2012/10
55.	Original article	Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. 2012/02
56.	Original article	Impact of ovarian sex steroids on ovulation and ovulatory gene induction in aromatase-null mice. 2012/01
57.	Original article	High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac muscles. 2012
58.	Other	Is impaired Kupffer cell function really important to the pathogenesis of nonalcoholic steatohepatitis? 2012
59.	Other	Is rosuvastatin effective for non-alcoholic steatohepatitis with dyslipidemia? 2012
60.	Original article	Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. 2012
61.	Original article	Usefulness of Technetium-99 m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease. 2012
62.	Original article	Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population. 2012
63.	Original article	A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet. 2011
64.	Original article	Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis. 2011
65.	Original article	Current status and agenda in the diagnosis of nonalcoholic steatohepatitis in Japan. 2010/10
66.	Original article	uper paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. 2010
67.	Original article	Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis. 2007
68.	Original article	Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. 2004
69.	Original article	Transactivation of transforming growth factor alpha gene by hepatitis B virus preS1. 1998
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■ Academic conference presentation

1.	Gender difference of liver fibrosis among hepatitis C dialysis patients: A pilot study 2021/06/04
2.	Two case reports of PD-1/PD-L1 inhibitor induced colitis resembling ulcerative colitis: case one with nivolumab followed by atezolizmumab, and case two with pembrolizmab 2019/12/13

■ Research areas

Gastroenterology (Key Word：nonalcoholic steatohepatitis (NASH))

■ Academic society memberships

Americam Gastroenterology Association

■ Education

1.		Faculty of Medicine, Kochi Medical School, Graduated,
2.		〔Doctoral course〕, Graduate School, Division of Medicine, Kochi Medical School, Completed,

■ Academic & professional experience

1.	2015/02～2019/07	Associate Professor
2.	2007/12～2015/01	Lecturer
3.	2004/04～2005/03	Research Assistant
4.	2003/10～2004/03	Research Assistant
5.	2002/11～2003/09	Research Assistant
6.	2001/09～2002/10	Johns Hopkins University, School of Medicine Gastroenterolog Researcher
7.	2000/02～2001/08	Baylor College of Medicine Infectious diseases Researcher
8.	1998/06～2000/01	Research Assistant
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