Faculty Information - Utsugisawa Taijiyu

（Last updated : 2023-05-30 10:39:04）

Utsugisawa Taijiyu
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Associate Professor

■ Published papers

1.	Original article	Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis 2023/03/02
2.	Original article	A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1 2022/04/21
3.	Original article	Clinical and genetic diagnosis of thirteen Japanese patients with hereditary spherocytosis 2022/01/12
4.	Original article	The Amount of Fibrinogen in Cryoprecipitate by In-hospital Preparation 2021
5.	Original article	Novel COL4A1 mutations identified in infants with congenital hemolytic anemia in association with brain malformations 2020/11
6.	Original article	KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells. 2019/05
7.	Original article	Safety and efficacy of cell-free and concentrated ascites reinfusion therapy (CART) in refractory ascites: Post-marketing surveillance results. 2017
8.	Original article	ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. 2016/05
9.	Original article	Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia. 2016/04
10.	Original article	Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia. 2008/02
11.	Original article	Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency. 2007/06
12.	Original article	Smad7 promotes self-renewal of hematopoietic stem cells. 2006/12
13.	Original article	A road map toward defining the role of Smad signaling in hematopoietic stem cells. 2006/04
14.	Original article	Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia. 2006
15.	Original article	Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia. 2005/06
16.	Original article	Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKCdelta inhibition. 2005/04
17.	Original article	Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19. 2005/04
18.	Original article	Short consensus probes with 3'-minor groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas. 2004/07
19.	Original article	Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas. 2003/10
20.	Original article	Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative-polymerase chain reaction. 2003/10
21.	Original article	Clonal evolution of blasts in an elderly patient with CD56(+) relapsed acute promyelocytic leukemia. 2002/01
22.	Original article	Function for p300 and not CBP in the apoptotic response to DNA damage. 1999/10
23.	Original article	Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. 1999/04
24.	Original article	Role for p300 in stabilization of p53 in the response to DNA damage. 1999/01
25.	Original article	Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. 1998/04
26.	Original article	Regulation of Rad51 function by c-Abl in response to DNA damage. 1998/02
27.	Original article	Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine. 1997/10
28.	Original article	Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. 1997/09
29.	Original article	Role for E2F in DNA damage-induced entry of cells into S phase. 1997/09
30.	Original article	A combination chemotherapy with low doses of cytarabine and etoposide for high risk myelodysplastic syndromes and their leukemic stage. A pilot study. 1996/08
31.	Original article	Tetrasomy of Philadelphia chromosome in myeloblastic crisis of chronic myelogenous leukemia. 1995/06
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■ Academic conference presentation

1.	Efficient Screening Tests and Gene Mutation Spectrum for Hereditary Stomatocytosis in Japan. 2021/12
2.	CART, Its Current Status and Prospect for the Future Leaps 2　Safety and quality control for filtered and concentrated ascites reinfusion therapy 2019/10/19
3.	Differential Diagnosis Of Congenital Hemolytic Anemia Of Neonates And Infants In Japan. 2019/06/13
4.	Meta-Analysis Using Data Of Red Cell Enzyme Assay And Proteome In Patients With Diamond-Blackfan Anemia 2019/06/13
5.	Clinical and laboratory characteristics of neonatal cases suspected with infantile pyknocytosis. 2018/10/12
6.	Usefulness of comprehensive genetic testing for the diagnosis of congenital hemolytic anemia 2018/10/12
7.	Pyruvate kinase deficiency in Japan: A Summary of clinical feature, laboratory data and enzymatic diagnosis. 2018/06/15
8.	The Flow Cytometric Osmotic Fragility Test Is an Effective Screening Method for Dehydrated Hereditary Stomatocytosis 2017/12/09
9.	The Flow Cytometric Osmotic Fragility Test is an Effective Screening Test for Red Cell Membrane Disorders, Including Dehydrated Hereditary Stomatocytosis 2017/05/05
10.	The Novel Missense Mutation of GATA1 Caused Red Cell Adenosine Deaminase Overproduction Associated with Congenital Hemolytic Anemia. 2016/12/03
11.	Congenital hemolytic anemia due to red cell enzymopathies. 2016/05/21
12.	Next Generation Sequencing in Diagnosis of Congenital Hemolytic Anemia. 2016/05/20
13.	COL4A1 is a novel causative gene responsible for congenital hemolytic anemia, representing characteristic clinical course in infants. 2015/12/05
14.	Bone marrow cell culture supplemented with high concentration of pyruvic acid be beneficial therapeutic neovacularization 2007/03
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■ Academic & professional experience

2022/11～

Associate Professor