Faculty Information - Imai Youichi

（Last updated : 2020-08-19 16:51:10）

Imai Youichi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Hematology

Position

■ Published papers

1.	Original article	Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation. 2018/04
2.	Review article	Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies. 2016/11
3.	Original article	Cytomegalovirus reactivation in low-grade B-cell lymphoma patients treated with bendamustine. 2016/09
4.	Original article	Incidence and clinical background of hepatitis B virus reactivation in multiple myeloma in novel agents' era. 2016/09
5.	Original article	Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma. 2016/04
6.	Original article	Post-transplant lymphoproliferative disorder in kidney transplant recipients: A single-center experience in Japan. 2016/04
7.	Original article	Donor cell-derived leukemia after cord blood transplantation and a review of the literature: differences between cord blood and BM as the transplant source. 2014/01
8.	Original article	Usefulness of the revised international prognostic index for diffuse large B-cell lymphoma patients treated with rituximab-based chemotherapy 2013/03
9.	Case report	Combined romiplostim and intravenous immunoglobulin therapy increased platelet count, facilitating splenectomy in a patient with refractory immune thrombocytopenic purpura unresponsive to monotherapy 2012/09
10.	Original article	Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation. 2012
11.	Case report	A Case of Myeloid Sarcoma with Correlation to JAK2V617F Mutation, Complicated by Myelofibrosis and Secondary Acute Myeloid Leukemia. 2011
12.	Original article	AML1/RUNX1 functions as a cytoplasmic attenuator of NF-kB signaling in the repression of myeloid tumors. 2011
13.	Case report	Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin. 2011
14.	Original article	Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells. 2011
15.	Original article	Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. 2011
16.	Original article	Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. 2011
17.	Case report	Fatal amebic colitis after high-dose dexamethasone therapy for newly diagnosed multiple myeloma. 2011
18.	Original article	Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through downregulation of p19ARF. 2011
19.	Case report	Nilotinib-induced hypothyroidism in a patient with chronic myeloid leukemia. 2011
20.	Original article	The negative impact of female donor/male recipient combination in allogeneic hematopoietic stem cell transplantation depends on disease risk. 2011
21.	Case report	A case of anaplastic large cell lymphoma, ALK positive, primary presented in the skin and relapsed with systemic involvement and leukocytosis after years of follow-up period. 2010
22.	Case report	A case report of non-traumatic renal artery pseudoaneurysm due to chemotherapy for diffuse large B-cell lymphoma. 2010
23.	Case report	CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement. 2010
24.	Original article	Distinct roles for LFA-1 affinity regulation during T cell adhesion, diapedesis, and interstitial migration in lymph nodes. 2010
25.	Original article	Efficacy and safety of modified rituximab-ESHAP therapy for relapsed/refractory B-cell lymphoma. 2010
26.	Review article	Essential roles of VLA-4 in the hematopoietic system. 2010
27.	Original article	EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. 2010
28.	Case report	High-dose dexamethasone therapy for severe thrombocytopenia and neutropenia induced by EBV infectious mononucleosis. 2010
29.	Case report	HIV-negative, HHV-8-unrelated primary effusion lymphoma-like lymphoma: report of two cases. 2010
30.	Case report	IgG-associated immune thrombocytopenia in Waldenstrom macroglobulinemia. 2010
31.	Original article	Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT. 2010
32.	Review article	Post-transplant lymphoproliferative disorder after adult-to adult living donor liver transplant: case series and review of literature. 2010
33.	Case report	Reversible posterior leukoencephalopathy syndrome following R-CHOP therapy for diffuse large B-cell lymphoma. 2010
34.	Case report	T cell acute lymphoblastic leukemia arising from familial platelet disorder. 2010
35.	Case report	Acute eosinophilic pneumonia is a non-infectious lung complication after allogeneic hematopoietic stem cell transplantation. 2009
36.	Case report	Chronic myelomonocytic leukemia presenting severe uterine hemorrhage due to uterine infiltration of leukemic cells and early-stage endometrial adenocarcinoma. 2009
37.	Original article	Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. 2009
38.	Review article	Interstitial pneumonia associated with progression of myelodysplastic syndrome. 2009
39.	Original article	Monitoring trough concentration of voriconazole is important to ensure successful antifungal therapy and to avoid hepatic damage in patients with hematological disorders. 2009
40.	Original article	Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. 2009
41.	Case report	Successful haematopoietic stem cell transplantation from an HLA-identical sibling in a patient with aplastic anemia following HLA-haploidentical living-related liver transplantation for fulminant hepatitis. 2009
42.	Original article	A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. 2008
43.	Original article	Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates a4 integrins. 2008
44.	Original article	Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab with or without CD52-positive malignancies. 2006
45.	Original article	Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase. 2005
46.	Original article	Notch1 oncoprotein antagonizes TGF-b/Smad-mediated cell growth suppression via sequestration of coactivator p300. 2005
47.	Original article	Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP. 2005
48.	Original article	AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues. 2004
49.	Original article	Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantation. 2004
50.	Original article	Functional analysis of a dominant-negative Delta ETS TEL/ETV6 isoform. 2004
51.	Original article	Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion. 2004
52.	Original article	Leukemia-related transcription factor TEL is negatively regulated through extracellular signal-regulated kinase-induced phosphorylation. 2004
53.	Original article	Predictors for severe cardiac complications after hematopoietic stem cell transplantation. 2004
54.	Original article	The Corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1. 2004
55.	Original article	The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region. 2004
56.	Original article	Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. 2003
57.	Original article	Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis. 2003
58.	Original article	Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation. 2003
59.	Review article	Should young patients with e19a2 type BCR/ABL rearrangement undergo stem cell transplantation? 2003
60.	Original article	Functional regulation of TEL by p38-induced phosphorylation. 2002
61.	Review article	Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. 2002
62.	Original article	Mutations of Chk2 in primary hematopoietic neoplasms. 2002
63.	Original article	The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP. 2002
64.	Original article	Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis. 2001
65.	Original article	The corepressor CtBP interacts with Evi-1 to repress transforming growth factor-b signaling. 2001
66.	Case report	Hepatocellular carcinoma followed by Waldenstrom's macroglobulinemia. 2000
67.	Original article	Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis. 2000
68.	Original article	The AML1/ETO (MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2b (CBFb) in the nucleus more efficiently than wild-type AML1. 1998
69.	Original article	The t(3;21) fusion product, AML1/Evi-1, interacts with Smad3 and blocks transforming growth factor-b-mediated growth inhibition of myeloid cells. 1998
70.	Original article	TLE, the human homolog of Groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation. 1998
71.	Original article	Bronchiolitis obliterans organizing pneumonia after syngeneic bone marrow transplantation for acute lymphoblastic leukemia. 1997
72.	Original article	The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. 1996
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■ Academic conference presentation

1.	Prospective analysis of cytomegalovirus reactivation in bendamustine treatment 2016/10/15
2.	Clinical significance of serum soluble and plasma cell-surface SLAMF3 levels in multiple myeloma 2016/10/14
3.	An aggressive myeloma patient with high KL-6 production and clinical impact of serum of KL-6 in myeloma 2016/10/13
4.	Clinical Significance of IL-6 and IGF-1 receptor expression on myeloma cells 2016/10/13
5.	Seven cases of non-Hodgkin B-cell lymphoma with heart involvement at diagnosis 2016/10/13
6.	The impact of serum soluble SLAMF7 on myeloma pathogenesis and anti-SLAMF7 antibody-based therapy 2016/10/13
7.	Fractionated ICE with rituximab is safe and effective for relapse/refractory DLBCL patients with severe comorbidities 2015/12/06
8.	Prospective analysis of cytomegalovirus reactivation and the immune state of low-grade B-cell lymphoma patients treated with bendamustine 2014/12/08
9.	Knockdown of a wnt receptor FZD1 reduces MDR1/P-glycoprotein expression in human leukemia cells through the Wnt/β-catenin signaling pathway 2014/12/07
10.	Clinical utility of slam family member CD229 in identifying tumor cells and high-risk disease markers, CD86 (B7-2) and CD126 (IL-6 receptor), using flow cytometric analysis in multiple myeloma 2014/12/06
11.	Interaction between B7-H1 molecules on myeloma cells and PD-1 molecules on T cells induces resistance to antimyeloma chemotherapy 2014/12/06
12.	Characteristics of multiple myeloma patients with high expression of B7-H1 (PD-L1) on tumors 2014/11/01
13.	MDR1 and Wnt receptor FZD1 genes expression in acute myeloid leukemic cells with normal karyotypes 2014/10/31
14.	RELAL-88 exhibited high remission rates in refractory or relapsed adult precursor lymphoid neoplasms 2014/10/31
15.	Expansion of NK cells from peripheral blood mononuclear cells using GMP-compliant substances without feeder cells for adaptive NK cell therapy 2014/06/12
16.	Knock-down of FZD1 reduced MDR1/P-gp expression in leukemic cells through the Wnt/β-catenin pathway 2013/10/13
17.	Identification of PPP3CA, catalytic subunit of Calcineurin as a target of multiple myeloma therapy 2013/10/12
18.	Long term efficacy of laparoscopic splenectomy for immune thrombocytopenia 2013/10/12
19.	Thrombotic thrombocytopenic purpura diagnosed after a twenty-year history of thrombocytopenia 2013/10/12
20.	A case of acute myeloid leukemia with t(11;19) (q23;p13.1) accompanied by severe DIC 2013/10/11
21.	Doner cell leukemia after cord blood transplantation: Compareing to BM as transplanted source 2013/10/11
22.	t(6;8) (p21;q24) in blastic plasmacytoid dendritic cell neoplasma 2013/10/11
23.	Identification of calcineurin as a novel therapeutic target in multiple myeloma 2013/04/04
24.	MLL-HOXA9 and calcineurin are nobel therapeutic targets in multiple myeloma 2012/12/10
25.	MLL is a novel target of anti-myeloma therapy and it is degraded by inhibitors of HDAC and HSP90 2012/10/21
26.	Successfully treated elderly blastic plasmacytoid dendritic cell neoplasm with t(6;8)(p21;q24) 2012/10/19
27.	Wnt receptor frizzled-1 silencing resulted a decrease of MDR1/P-glycoprotein in leukemic cell lines 2012/10/19
28.	Clinical course of adult non-severe aplastic anemia 2011/10/14
29.	Long-term clinical outcome of patients with chronic myeloid leukemia treated with interferon-alpha 2011/10/14
30.	Prolonged activated partial thromboplastin time in a case of CMV-related infectious mononucleosis 2011/10/14
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